Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 (Q06508)

Identification
NameLysophosphatidic acid:oleoyl-CoA acyltransferase 1
Synonyms
  • LPAAT
  • Lysophosphatidic acid acyltransferase
  • Vacuolar protein sorting-associated protein 66
Gene NameLOA1
Enzyme ClassNot Available
Biological Properties
General Functionlipid particle organization
Specific FunctionAcyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting.
Cellular LocationNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(10:0/14:0/16:1(11Z)/26:1(11Z))PW004109 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/14:0/16:1(11Z)/26:1(9Z))PW004110 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/14:0/16:1(11Z)/28:0)PW004111 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/14:0/16:1(11Z)/28:1(11Z))PW004112 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/14:0/16:1(11Z)/28:1(9Z))PW004113 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycerophospholipid metabolismec00564 Map00564
SMPDB Reactions
LPA(10:0/0:0) + long-chain fatty acyl-CoA → Coenzyme A + PA(10:0/23:1(9Z))
LPA(14:0/0:0) + long-chain fatty acyl-CoA → Coenzyme A + PA(14:0/15:1(9Z))
LPA(14:1(9Z)/0:0) + long-chain fatty acyl-CoA → Coenzyme A + PA(14:1(9Z)/15:0)
LPA(12:0/0:0) + long-chain fatty acyl-CoA → Coenzyme A + PA(12:0/20:0)
LPA(14:0/0:0) + long-chain fatty acyl-CoA → Coenzyme A + PA(14:0/16:0)
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00045Coenzyme AShow
YMDB00069Palmitic acidShow
YMDB00301Palmityl-CoAShow
YMDB00539oleoyl-CoAShow
YMDB01127DG(16:0/16:0/0:0)Show
YMDB01160PA(16:0/0:0)Show
YMDB01161PA(16:0/16:0)Show
YMDB163021-oleyl-2-lyso-phosphatidateShow
GO Classification
Function
lipid metabolic process
endoplasmic reticulum
lipid particle
lipid particle organization
1-acylglycerol-3-phosphate O-acyltransferase activity
lysophosphatidic acid acyltransferase activity
cellular triglyceride homeostasis
integral component of membrane
endoplasmic reticulum membrane
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>903 bp ATGGAAAAGTACACCAATTGGAGAGACAATGGTACGGGAATAGCTCCATTTCTACCAAAC ACAATCAGGAAACCTAGTAAGGTGATGACAGCGTGTTTGTTGGGTATCCTAGGGGTGAAA ACCATTATAATGCTACCATTGATTATGCTGTACCTTCTAACTGGCCAGAACAACTTACTG GGTTTGATATTGAAGTTTACATTCAGTTGGAAAGAGGAAATTACCGTGCAAGGAATCAAG AAACGTGACGTAAGGAAATCCAAGCATTATCCACAGAAGGGCAAGCTTTATATTTGCAAT TGTACCTCACCTTTAGATGCTTTTTCAGTGGTGTTATTAGCTCAAGGGCCTGTTACGTTG TTGGTCCCATCCAATGACATTGTATACAAAGTTTCCATAAGAGAATTCATCAACTTCATC CTCGCCGGTGGGTTAGATATAAAACTCTATGGCCACGAGGTAGCAGAGCTATCTCAATTG GGCAATACCGTGAATTTTATGTTTGCTGAGGGTACCTCATGTAATGGTAAAAGCGTCTTA CCGTTTAGTATAACCGGGAAAAAACTTAAAGAATTCATAGACCCTTCAATAACCACAATG AACCCCGCAATGGCCAAAACTAAAAAATTTGAATTGCAGACCATCCAAATCAAAACTAAT AAAACTGCCATCACCACATTGCCCATCTCCAATATGGAGTATTTATCTAGATTTCTGAAC AAGGGCATTAATGTTAAATGCAAGATCAACGAGCCACAAGTACTCTCGGATAATTTAGAG GAATTACGCGTTGCATTAAACGGTGGCGACAAATATAAACTAGTCTCACGGAAGTTAGAT GTTGAATCTAAGAGGAATTTTGTGAAGGAATATATCAGCGATCAACGTAAAAAGAGGAAG TAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues300
Protein Molecular Weight33815.635
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane Regions
  • 33-53
Protein Sequence>Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 MEKYTNWRDNGTGIAPFLPNTIRKPSKVMTACLLGILGVKTIIMLPLIMLYLLTGQNNLL GLILKFTFSWKEEITVQGIKKRDVRKSKHYPQKGKLYICNCTSPLDAFSVVLLAQGPVTL LVPSNDIVYKVSIREFINFILAGGLDIKLYGHEVAELSQLGNTVNFMFAEGTSCNGKSVL PFSITGKKLKEFIDPSITTMNPAMAKTKKFELQTIQIKTNKTAITTLPISNMEYLSRFLN KGINVKCKINEPQVLSDNLEELRVALNGGDKYKLVSRKLDVESKRNFVKEYISDQRKKRK
References
External Links
ResourceLink
Saccharomyces Genome Database LOA1
Uniprot IDQ06508
Uniprot NameLOA1
General ReferenceNot Available