Peroxisomal adenine nucleotide transporter 1 (Q06497)

Identification
NamePeroxisomal adenine nucleotide transporter 1
SynonymsNot Available
Gene NameANT1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in adenine nucleotide transmembrane transporte
Specific FunctionAdenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxydation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation
Cellular LocationPeroxisome membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00097Adenosine monophosphateShow
YMDB00109Adenosine triphosphateShow
YMDB00862hydronShow
YMDB00914ADPShow
GO Classification
Component
cell part
membrane
Function
binding
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 16
LocusYPR128C
Gene Sequence>987 bp ATGTTAACTCTAGAGTCTGCATTAACTGGCGCTGTGGCTTCGGCAATGGCCAATATTGCA GTTTATCCGCTGGATTTATCGAAGACGATCATTCAGTCACAAGTATCTCCTTCTTCAAGT GAGGATAGTAACGAAGGTAAAGTTTTGCCCAATAGGAGATATAAGAATGTTGTAGATTGC ATGATAAACATATTCAAAGAAAAGGGTATTTTGGGTCTGTATCAAGGTATGACAGTCACT ACGGTGGCCACATTTGTCCAGAATTTTGTTTATTTCTTTTGGTACACATTTATCAGAAAG TCCTACATGAAACATAAGCTGTTAGGACTGCAATCACTGAAAAACCGCGATGGTCCTATC ACACCTTCTACGATTGAAGAATTGGTACTTGGGGTAGCAGCTGCCAGTATATCGCAACTT TTTACTAGTCCCATGGCTGTGGTAGCTACAAGACAACAAACAGTCCATTCTGCAGAGTCT GCCAAATTTACCAACGTTATTAAGGACATTTACCGTGAAAATAATGGGGACATAACTGCT TTTTGGAAAGGTTTAAGAACAGGTTTAGCATTGACGATAAATCCTTCCATCACATATGCC TCTTTTCAAAGACTTAAAGAAGTTTTTTTCCATGACCATTCCAACGATGCTGGCAGTTTG TCAGCAGTGCAAAATTTCATTTTGGGTGTCCTTTCCAAGATGATTTCGACTCTAGTTACG CAACCCTTGATTGTCGCTAAAGCAATGCTTCAAAGCGCTGGCTCTAAATTCACTACTTTC CAAGAAGCGCTACTATACTTGTACAAAAATGAAGGGTTAAAATCTCTTTGGAAGGGAGTT CTTCCTCAATTGACAAAGGGTGTCATTGTGCAAGGTCTGTTGTTTGCTTTCAGAGGAGAA TTGACAAAATCTTTAAAGAGGCTAATATTCTTGTACTCTTCTTTTTTCCTAAAGCACAAC GGACAACGCAAGCTGGCTTCCACTTGA
Protein Properties
Pfam Domain Function
Protein Residues328
Protein Molecular Weight36367.0
Protein Theoretical pI10.33
Signalling Regions
  • None
Transmembrane Regions
  • 1-21
  • 78-98
  • 128-148
  • 185-202
  • 226-246
  • 277-297
Protein Sequence>Peroxisomal adenine nucleotide transporter 1 MLTLESALTGAVASAMANIAVYPLDLSKTIIQSQVSPSSSEDSNEGKVLPNRRYKNVVDC MINIFKEKGILGLYQGMTVTTVATFVQNFVYFFWYTFIRKSYMKHKLLGLQSLKNRDGPI TPSTIEELVLGVAAASISQLFTSPMAVVATRQQTVHSAESAKFTNVIKDIYRENNGDITA FWKGLRTGLALTINPSITYASFQRLKEVFFHDHSNDAGSLSAVQNFILGVLSKMISTLVT QPLIVAKAMLQSAGSKFTTFQEALLYLYKNEGLKSLWKGVLPQLTKGVIVQGLLFAFRGE LTKSLKRLIFLYSSFFLKHNGQRKLAST
References
External Links
ResourceLink
Saccharomyces Genome Database ANT1
Uniprot IDQ06497
Uniprot NameANT1_YEAST
GenBank Gene IDU40829
Genebank Protein ID1066487
General Reference
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Palmieri, L., Rottensteiner, H., Girzalsky, W., Scarcia, P., Palmieri, F., Erdmann, R. (2001). "Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter." EMBO J 20:5049-5059.11566870
  • van Roermund, C. W., Drissen, R., van Den Berg, M., Ijlst, L., Hettema, E. H., Tabak, H. F., Waterham, H. R., Wanders, R. J. (2001). "Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae." Mol Cell Biol 21:4321-4329.11390660
  • Rottensteiner, H., Palmieri, L., Hartig, A., Hamilton, B., Ruis, H., Erdmann, R., Gurvitz, A. (2002). "The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction." Biochem J 365:109-117.12071844
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Lasorsa, F. M., Scarcia, P., Erdmann, R., Palmieri, F., Rottensteiner, H., Palmieri, L. (2004). "The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in DeltapH formation across peroxisomal membranes." Biochem J 381:581-585.15219179
  • van Roermund, C. W., de Jong, M., IJlst, L., van Marle, J., Dansen, T. B., Wanders, R. J., Waterham, H. R. (2004). "The peroxisomal lumen in Saccharomyces cerevisiae is alkaline." J Cell Sci 117:4231-4237.15316083