Protein UPS1, mitochondrial (Q05776)

Identification
NameProtein UPS1, mitochondrial
Synonyms
  • Unprocessed MGM1 protein 1
Gene NameUPS1
Enzyme ClassNot Available
Biological Properties
General Functionpositive regulation of phosphatidylcholine biosynthetic process
Specific FunctionRequired for maintenance of normal mitochondrial morphology (PubMed:16754953, PubMed:26071601). Required for PCP1-dependent processing of MGM1 (PubMed:16754953). The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex (PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602). With UPS2, controls the level of cardiolipin in mitochondria (PubMed:19506038). Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits.
Cellular LocationNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(10:0/10:0/23:1(9Z)/27:0)PW003704 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/23:1(9Z)/27:1(11Z))PW003705 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/23:1(9Z)/27:1(9Z))PW003706 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/23:1(9Z)/29:0)PW003707 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/24:0/26:0)PW003708 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
lipid binding
mitochondrial intermembrane space
phospholipid transport
extrinsic component of mitochondrial inner membrane
phosphatidic acid transporter activity
cardiolipin metabolic process
positive regulation of phosphatidylcholine biosynthetic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>528 bp ATGGTCCTTTTACACAAAAGCACACATATATTTCCTACCGATTTTGCCTCTGTTTCACGC GCCTTTTTTAATAGATACCCCAATCCATACTCCCCCCATGTACTATCCATAGACACAATA TCAAGGAACGTTGATCAAGAAGGAAATTTGCGCACAACGAGGCTGTTGAAAAAGTCCGGA AAGCTGCCCACATGGGTCAAACCCTTTTTAAGAGGTATAACAGAAACATGGATAATCGAA GTTTCCGTAGTGAACCCCGCTAACTCCACAATGAAAACTTACACTAGGAATCTGGATCAC ACTGGAATCATGAAGGTTGAAGAATATACTACCTATCAATTTGACAGTGCTACAAGTAGT ACGATAGCAGACAGCCGGGTGAAGTTTTCAAGTGGCTTCAATATGGGTATCAAATCTAAG GTAGAGGATTGGTCGCGCACTAAATTTGACGAAAACGTTAAGAAAAGCAGAATGGGCATG GCATTTGTTATCCAAAAACTCGAAGAGGCGAGAAATCCTCAGTTTTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues175
Protein Molecular Weight20107.82
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Protein UPS1, mitochondrial MVLLHKSTHIFPTDFASVSRAFFNRYPNPYSPHVLSIDTISRNVDQEGNLRTTRLLKKSG KLPTWVKPFLRGITETWIIEVSVVNPANSTMKTYTRNLDHTGIMKVEEYTTYQFDSATSS TIADSRVKFSSGFNMGIKSKVEDWSRTKFDENVKKSRMGMAFVIQKLEEARNPQF
References
External Links
ResourceLink
Saccharomyces Genome Database UPS1
Uniprot IDQ05776
Uniprot NameUPS1
PDB ID
4XHR
General ReferenceNot Available