Arginyl-tRNA synthetase, cytoplasmic (Q05506)

Identification
NameArginyl-tRNA synthetase, cytoplasmic
Synonyms
  • Arginine--tRNA ligase
  • ArgRS
Gene NameNot Available
Enzyme Class
Biological Properties
General FunctionInvolved in nucleotide binding
Specific FunctionForms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
L-Arginine + Adenosine triphosphate + tRNA(Arg) → Adenosine monophosphate + Pyrophosphate + Arg-tRNA(Arg)
Metabolites
YMDB IDNameView
YMDB00097Adenosine monophosphateShow
YMDB00109Adenosine triphosphateShow
YMDB00219PyrophosphateShow
YMDB00592L-ArginineShow
GO Classification
Component
intracellular part
cytoplasm
cell part
Function
binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
arginine-tRNA ligase activity
adenyl ribonucleotide binding
ATP binding
ligase activity, forming carbon-oxygen bonds
ligase activity, forming aminoacyl-tRNA and related compounds
catalytic activity
aminoacyl-tRNA ligase activity
nucleotide binding
ligase activity
Process
tRNA aminoacylation
tRNA aminoacylation for protein translation
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
translation
arginyl-tRNA aminoacylation
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
RNA metabolic process
ncRNA metabolic process
biosynthetic process
tRNA metabolic process
Gene Properties
Chromosome LocationNot Available
LocusYDR341C
Gene Sequence>1824 bp ATGGCTAGCACAGCAAATATGATTTCTCAACTAAAGAAACTATCTATCGCGGAACCTGCG GTTGCCAAGGATTCTCATCCTGATGTAAATATCGTGGATTTGATGAGAAATTACATTTCA CAAGAATTAAGCAAGATTTCCGGCGTAGACTCGTCTCTTATTTTTCCAGCATTAGAATGG ACAAATACTATGGAGAGAGGCGATTTGTTGATTCCTATCCCAAGATTGAGAATCAAAGGT GCCAATCCAAAGGATTTGGCAGTCCAATGGGCTGAAAAATTTCCATGTGGAGATTTCTTG GAGAAAGTTGAAGCGAATGGCCCGTTCATCCAGTTTTTCTTCAACCCTCAATTTTTAGCA AAACTTGTCATCCCAGATATCTTAACCAGAAAGGAGGATTATGGTTCTTGCAAATTGGTT GAAAACAAGAAAGTTATTATTGAATTCTCCTCTCCCAACATTGCCAAGCCATTTCATGCT GGTCATTTAAGATCCACTATTATTGGTGGCTTTTTGGCCAACCTTTATGAAAAATTAGGT TGGGAGGTTATCAGAATGAACTACCTGGGTGACTGGGGTAAACAATTTGGTCTTTTAGCT GTTGGTTTTGAAAGATACGGTAATGAAGAGGCTTTAGTTAAGGATCCAATTCACCACCTG TTCGATGTTTACGTTCGTATCAACAAGGATATTGAGGAAGAAGGTGACAGTATTCCATTA GAACAATCCACCAATGGAAAAGCTCGTGAATATTTCAAGAGAATGGAAGATGGTGACGAG GAAGCTTTAAAAATTTGGAAGAGATTCCGTGAATTTTCTATTGAAAAATATATTGACACA TATGCACGTTTGAACATCAAATATGATGTTTACTCTGGTGAATCTCAAGTTTCTAAAGAA TCCATGCTCAAAGCTATCGACCTGTTCAAGGAAAAGGGCTTAACACATGAGGATAAGGGT GCAGTTTTGATCGATTTGACAAAATTTAACAAAAAGTTAGGAAAGGCTATTGTTCAAAAA TCGGACGGTACTACGTTATATCTAACTAGAGACGTTGGTGCAGCTATGGACCGTTATGAA AAGTATCATTTTGACAAGATGATTTACGTTATCGCTTCTCAACAAGATTTGCACGCTGCC CAATTCTTCGAAATTTTGAAGCAGATGGGCTTTGAGTGGGCTAAAGATCTACAGCATGTC AACTTTGGTATGGTCCAAGGTATGTCAACAAGAAAAGGTACTGTTGTCTTCTTAGATAAT ATCTTGGAGGAAACTAAGGAAAAAATGCACGAAGTTATGAAAAAGAATGAGAACAAATAC GCGCAAATTGAGCATCCAGAAGAAGTTGCCGATTTAGTTGGTATCTCTGCCGTCATGATT CAAGATATGCAAGGTAAGCGTATCAACAACTACGAGTTTAAATGGGAAAGAATGCTTTCA TTCGAAGGTGACACTGGTCCATACCTTCAATATGCTCACTCAAGGTTAAGATCAGTTGAA AGAAATGCTTCTGGTATCACCCAAGAAAAATGGATAAATGCCGATTTTTCGTTATTAAAA GAACCTGCCGCAAAACTGTTGATTAGACTGCTAGGCCAATACCCCGATGTTTTGAGAAAT GCAATCAAAACCCACGAGCCAACAACCGTGGTCACATATTTATTCAAATTGACTCACCAG GTTTCTTCTTGTTATGACGTCTTATGGGTTGCTGGTCAAACTGAAGAATTAGCAACTGCC CGTCTGGCTCTATATGGTGCTGCAAGACAAGTTTTATACAACGGTATGCGCTTGTTAGGT TTAACTCCCGTAGAAAGAATGTAA
Protein Properties
Pfam Domain Function
Protein Residues607
Protein Molecular Weight69524.39844
Protein Theoretical pI6.76
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Arginyl-tRNA synthetase, cytoplasmic MASTANMISQLKKLSIAEPAVAKDSHPDVNIVDLMRNYISQELSKISGVDSSLIFPALEW TNTMERGDLLIPIPRLRIKGANPKDLAVQWAEKFPCGDFLEKVEANGPFIQFFFNPQFLA KLVIPDILTRKEDYGSCKLVENKKVIIEFSSPNIAKPFHAGHLRSTIIGGFLANLYEKLG WEVIRMNYLGDWGKQFGLLAVGFERYGNEEALVKDPIHHLFDVYVRINKDIEEEGDSIPL EQSTNGKAREYFKRMEDGDEEALKIWKRFREFSIEKYIDTYARLNIKYDVYSGESQVSKE SMLKAIDLFKEKGLTHEDKGAVLIDLTKFNKKLGKAIVQKSDGTTLYLTRDVGAAMDRYE KYHFDKMIYVIASQQDLHAAQFFEILKQMGFEWAKDLQHVNFGMVQGMSTRKGTVVFLDN ILEETKEKMHEVMKKNENKYAQIEHPEEVADLVGISAVMIQDMQGKRINNYEFKWERMLS FEGDTGPYLQYAHSRLRSVERNASGITQEKWINADFSLLKEPAAKLLIRLLGQYPDVLRN AIKTHEPTTVVTYLFKLTHQVSSCYDVLWVAGQTEELATARLALYGAARQVLYNGMRLLG LTPVERM
References
External Links
ResourceLink
Saccharomyces Genome Database YDR341C
Uniprot IDQ05506
Uniprot NameSYRC_YEAST
GenBank Gene IDU51032
Genebank Protein ID1230668
PDB ID
1F7V
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
  • Cavarelli, J., Delagoutte, B., Eriani, G., Gangloff, J., Moras, D. (1998). "L-arginine recognition by yeast arginyl-tRNA synthetase." EMBO J 17:5438-5448.9736621