1,3-beta-glucan synthase component FKS3 (Q04952)

Identification
Name1,3-beta-glucan synthase component FKS3
Synonyms
  • 1,3-beta-D-glucan-UDP glucosyltransferase
  • FK506 sensitivity protein 3
Gene NameFKS3
Enzyme Class
Biological Properties
General FunctionInvolved in 1,3-beta-D-glucan synthase activity
Specific FunctionRequired for spore wall assembly
Cellular LocationMitochondrion. Membrane; Multi-pass membrane protein (Potential)
SMPDB Pathways
Starch and sucrose metabolismPW002481 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Starch and sucrose metabolismec00500 Map00500
SMPDB Reactions
1,3-beta-D-Glucan + Uridine 5'-diphosphate ↔ Uridine diphosphate glucose + 1,3-beta-D-Glucan
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00212Uridine diphosphate glucoseShow
YMDB00307Uridine 5'-diphosphateShow
YMDB00415UDP-D-glucoseShow
YMDB163141,3-beta-D-GlucanShow
GO Classification
Component
1,3-beta-glucan synthase complex
cell part
membrane
macromolecular complex
protein complex
Function
UDP-glycosyltransferase activity
UDP-glucosyltransferase activity
1,3-beta-glucan synthase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
polysaccharide metabolic process
glucan metabolic process
cellular glucan metabolic process
beta-glucan metabolic process
1,3-beta-glucan metabolic process
1,3-beta-glucan biosynthetic process
Gene Properties
Chromosome Locationchromosome 13
LocusYMR306W
Gene Sequence>5358 bp ATGGATTTTATGAGTCCCAAGTTTTCGCTAACTGACGTTGAGTATCCTGCTTGGTGCCAA GACGATGAAGTCCCAATAACAATGCAGGAAATTAGAGAAATTTTTGTGGAGCTCATGGAT AAGTTTGGCTTCCAGAAATCTTCTATGGAAAATATGTATCAACATTTAATGGGACAGCTG GACTCCAGGGCAAGTCGTACAGGTGCTCAAAATGCTTTAGTATCGCTACATGTTTCATAT ATTGGAGGCGAACACGCAAATTATAGAAAATGGTATTTTGCCGCTCAGCTCGATTTAGAT GAAGAGATCGGGTTTCAAAACATGCGACTACATGGAAAGGCACGCCAAAGAAACGTAAAA ATGGCGAAGAAAAGAGGCGTATCGATAAAGGAACAAATTAAGCAATGGAATGAGAAGGAG CAAGAGTTCATCAATAACCATCCAAAGATCACACTGACTCAAGAACAATTGGAAGATCAG ACAAACTTGAAAAGTGCAGACTACAAATGGAAATTGAAAATGAAAAAATTGACGCCCGAA AATATGATAAGACAGCTGGCCCTTTATTTGCTTTGCTGGGGTGAAGCCAATCAAGTCAGA TTCGCCCCAGAATGCCTTTGCTTTATTTTCAAATGTGCACTTGATTATGATATTAGTACG TCAAGTAGCGAAAAAACGGTGAAATCACCTGAGTATTCATACTTAAATGACGTTATTACT CCCTTATACGAATTCCTAAGGGGCCAAGTATACAAAAAAGACGCAAAGGGGAACTGGAAA CGAAGAGAAAAAGACCACAAGAATATTATTGGTTACGACGACATCAATCAATTATTTTGG TACCCGGAAGGATTTGAACGTATTATTTTAAACAATGGAGAACGATTAGTTGACAAGCCA TTGGAGGAGAGATATCTTTACTTTAAAGACGTTGCATGGTCTAAAGTATTTTATAAGACA TATAGAGAAACCAGAAGTTGGAAGCATTGTTTTACCAATTTCAATAGATTCTGGATTATC CATTTTGCACCGTTTTGGTTCTTCACCACATTTAATTCCCCCACTTTGTACACCAAGAAT TATATACAGTTATTGAATAACCAGCCTACACCCCAAGTTAGACTATCAGTGATTGCCTTT GGAGGCACAATTGCATGTTTAGTTCAAATTTTAGCCACCGTGTTCGAGTGGGGATTTGTA CCTCGAGAATGGCCAGGCGCTCAGCATTTATCGAGTAGAATGATTGGCTTACTTTTTTGT CTTGCAATCAATTTGGGACCTTCCGTGTATGTTCTGGGGTTTTTCGAATGGGATGTTCAT TCAAAATCTGCGTATATCGTGTCCATCGTCCAACTAATCATTGCATTTTTAACCACTTTT TTTTTTGCTGTCAGACCTTTGGGCGGCTTATTTCGTCCATATTTGAATAAAGACAAAAAA CATCGGAGGTACATCTCATCGCAAACCTTTACCGCTTCATTTCCTAAGCTGACAGGACGC AGCAAATGGTTTTCTTATGGGTTATGGGTATTTGTGTATTTGGCGAAATATATTGAGTCC TATTTTTTTTTGACCTTGTCCCTCAGGGACCCCATCAGGGTCCTCTCTATTATGGATTTG TCCAGATGTCAAGGTGAATATTTGTTGGGTCCTATTCTATGTAAATGGCAAGCCAAAATT ACATTAGTTCTCATGCTGCTTTCTGACTTGGGCCTGTTTTTTCTCGACACTTACCTTTGG TACATTATTTGCAACTGTATTTTTTCCATTGTACTGTCATTTTCTCTTGGTACTTCAATT CTCACGCCATGGAAGAATGTATACTCTCGATTGCCAAAAAGGATATATTCCAAAATCCTT GCTACTTCAGAGATGGATGTAAAATTTAAAGCAAAAATACTGATATCGCAGGTTTGGAAT GCCATTGTTATATCAATGTATAGGGAACATCTTCTCTCCATTGAACATTTACAAAGACTC TTGTTTCAGCAAGTTGACTCCTTAATGGGAGACACAAGAACCCTGAAATCGCCTACATTT TTCGTTGCACAAGATGATTCAACGTTCAAGTCAATGGAATTTTTTCCATCAAATTCAGAG GCAAAAAGAAGGATATCCTTTTTTGCCCAATCCCTGGCGACCCCCATTTCAGAACCTGTT CCAGTGGATTGTATGCCAACTTTTACCGTTTTGGTACCCCATTATTCAGAAAAGATTCTG TTGGGCTTGAAGGAAATTATCAGGGAAGAATCTCCTAAAAGTAAAATCACGGTGCTTGAG TATTTGAAGCATCTACACCCTACAGAATGGGAATGTTTTGTTAAGGATACCAAACTACTA AGCATGGAAAAGAGCTTTTTGAAAGAGGCAGAGAGCAGTCATGATGAAGATAGATTGGAA ATTCCGGATGCTCTGTACGATCCAAGGTCTAGCCCGCTTTCTGACCATACTGAGTCCCGG AAGTTGCCCACAGAAGACGATCTTATTAAGGAGAAAATTAATGATTTGCCATTTTCTTAC TTTGGCTTCAACTCATCAGAACCATCGTACACCCTGAGAACAAGAATCTGGGCATCATTG CGGACGCAGACTTTGTACCGAACCCTTTCAGGGTTTATGAACTATTCCAAAGCTATTAAG CTACTGTATCGAATTGAAAACCCCTCTTTAGTTAGCTTGTATCGTGGCAATAATGAAGCA TTGGAGAATGACTTAGAAAATATGGCTAGCAGGAAATTTAGGATGGTTGTTGCTATGCAG AGATATGCAAAATTTAATAAGGATGAAGTGGAGGCAACAGAACTACTTTTAAGAGCCTAT CCAAATATGTTTATATCTTACCTTTTGGAAGAATTAGAGCAAAATGAATCTGAGAAAACG TACTATTCGTGCCTGACTAATGGCTATGCTGAGTTTGACGAAGAAAGTGGATTAAGGAAG CCAATATTCAAAATTCGCCTGTCGGGCAATCCAATACTTGGCGATGGAAAATCGGATAAT CAGAACCATTCTATTATATTTTATCGTGGTGAGTATATTCAGGTGATTGATGCAAACCAA GATAATTATTTGGAGGAATGCCTAAAGATACGGTCTGTTTTAAGTGAGTTCGAAGAGCTT GAGCTTAATCCCACAATCCCATACATTCCTGGCATTGAATATGAAGAAGAACCACCGCCC ATCGCTATTGTTGGTTCAAGAGAGTATATTTTTTCAGAAAATATTGGAGTGTTAGGTGAT ATTGCTGCAGGTAAAGAACAGACTTTTGGAACCTTATTTGCTAGAACGTTGGCTGAAATT GGTGGTAAATTGCACTATGGGCATCCCGATTTTCTCAATGGCATTTTTATGACCACTCGT GGTGGCCTGTCTAAGGCACAAAGAGGATTGCATTTAAACGAGGATATATATGCTGGAATG AACGCAATCTGCCGTGGTGGAAAGATAAAACATAGTGATTACTACCAATGTGGTAAGGGT AGAGATTTGGGATTTGGGTCCATCCTGAATTTCACTACTAAAATAGGTGCAGGTATGGGG GAACAGCTACTATCAAGGGAGTACTATTATTTGGGGACACAACTTCCCATGGATAGATTT TTATCGTTTTTTTATGCACATCCTGGTTTCCATCTGAATAATCTTTTTATTTCCTTTTCG GTTCAACTGTTCTTCGTTCTGCTTTTAAACTTGGGTGCGTTGAACCATGAAATTATAGCC TGCTTTTACGACAAGGATGCACCAATTACAAATCTTGAGACACCCGTTGGTTGTTATAAT ATTCAGCCTGCATTGCATTGGGTATCGATATTCGTACTATCAATCTTCATTGTTTTCTTT ATTGCCTTTGCCCCTTTGCTGATTCAAGAAGTTTTGGAAAAGGGTATTTGGAGAGCAGCT TCAAGGTTCCTACATCATCTTCTTTCAATGGCCCCATTATTTGAAGTATTCGTCTGCCAA GTTTATTCGAATTCTCTATTGATGGACTTGACCTTTGGGGGAGCAAAGTACATATCTACA GGTCGTGGGTTTGCAATAACACGCCTCGATTTTTTTACGCTCTATTCCAGATTTGTTAAT ATATCGATATATTCTGGTTTCCAAGTGTTCTTCATGTTATTATTCGCGATTATTTCCATG TGGCAACCCGCCTTATTATGGTTTTGGATTACAGTCATTTCGATGTGCTTCGCACCTTTT ATTTTCAATCCACATCAGTTCGCATTCATGGATTTCTTCATTGATTATAAAACCTTTATC CACTGGTTATTCTCAGGTAACACGAAATATCAAAAAGAATCGTGGGCAAACTTTGTCAAG AGTTCTCGATCAAGATTTACGGGCTATAAAAGTAAAACTGTAGATGATATTTCCGAAGAT TCAGGCCATGATTCAAAGAAAGCGAGGTTTTGGAACGTCTTCTTTGCAGAACTATTTCTA CCTTTCTGTGTGTTCCTCTTCAACTTCACCGCTTTTTCTTTCATTAATGCACAAACAGGG GTCTCTGACTCAACACCAACTAGCGCTGTTTTCCGTTTGTTGCTCGTAACTTTTTTGCCA ATCTTTCTTAACTCAATAGTGCTTTTTCTATTATTTTGGGTTTCACTTTTTGTGGTTCCT GGATTGTCATATTGTTGTAAAGACGCAGGTGCCGTGATTGCGTTTATTGCACACACTTTC TCGGTTTTGGTCTATCTTTTAGATTTCGAACTGATGTGGTTCTTACAAGGTTGGAACTTT ACCCGTACATTGATACTGCTTATTACGTGCATCAATATGCATCTGATTCTTTTCAAGGTC TTTACGACGATATTCTTGACAAGGGAGTATAAAAACAATAAGGCACATTTGGCATGGTGG AATGGTAAATGGTACAATACGGGCATGGGCTGGTCTATCATTTTACAGCCCATACGAGAA TACTTCGTGAAGATTATGGAATCTAGTTATTTTGCAGCAGATTTCTTTCTTGGTCACTTC CTCTTATTTATACAAACGCCCATAATATTGTTACCATTTATCGATTACTGGCATACAATG GTGCTATTTTGGATGAATCCAAGAAGTATTATCGCGCATAAAAGAATTTTGACTCGAAAG CAGAGAGCATTAAGAAGTAGGATAGTTTCAAAATATTTCTCTCTATATTTTGTGATGCTA GGTGTGCTCCTTTTTATGCTCATCGCGCCATTCTTTGCTGGTGATTTCGTATCTAGTCCG CAAGAATTGCTGGAAGGCACCCTTTTCGAAGGAATCTTCCAACCTAACAACCAAAACAAC AACGATACTGGTCCAAATGCTCCATCGACAATCCTGACTACAACACCAACTTTACCTACC TTTAGGACTGTCGCATAG
Protein Properties
Pfam Domain Function
Protein Residues1785
Protein Molecular Weight207481.0
Protein Theoretical pI8.17
Signalling Regions
  • None
Transmembrane Regions
  • 337-357
  • 375-395
  • 415-435
  • 444-464
  • 508-528
  • 547-567
  • 572-592
  • 712-732
  • 1215-1235
  • 1268-1288
  • 1303-1323
  • 1370-1390
  • 1394-1414
  • 1475-1495
  • 1514-1534
  • 1549-1569
  • 1585-1605
  • 1655-1675
  • 1713-1733
Protein Sequence>1,3-beta-glucan synthase component FKS3 MDFMSPKFSLTDVEYPAWCQDDEVPITMQEIREIFVELMDKFGFQKSSMENMYQHLMGQL DSRASRTGAQNALVSLHVSYIGGEHANYRKWYFAAQLDLDEEIGFQNMRLHGKARQRNVK MAKKRGVSIKEQIKQWNEKEQEFINNHPKITLTQEQLEDQTNLKSADYKWKLKMKKLTPE NMIRQLALYLLCWGEANQVRFAPECLCFIFKCALDYDISTSSSEKTVKSPEYSYLNDVIT PLYEFLRGQVYKKDAKGNWKRREKDHKNIIGYDDINQLFWYPEGFERIILNNGERLVDKP LEERYLYFKDVAWSKVFYKTYRETRSWKHCFTNFNRFWIIHFAPFWFFTTFNSPTLYTKN YIQLLNNQPTPQVRLSVIAFGGTIACLVQILATVFEWGFVPREWPGAQHLSSRMIGLLFC LAINLGPSVYVLGFFEWDVHSKSAYIVSIVQLIIAFLTTFFFAVRPLGGLFRPYLNKDKK HRRYISSQTFTASFPKLTGRSKWFSYGLWVFVYLAKYIESYFFLTLSLRDPIRVLSIMDL SRCQGEYLLGPILCKWQAKITLVLMLLSDLGLFFLDTYLWYIICNCIFSIVLSFSLGTSI LTPWKNVYSRLPKRIYSKILATSEMDVKFKAKILISQVWNAIVISMYREHLLSIEHLQRL LFQQVDSLMGDTRTLKSPTFFVAQDDSTFKSMEFFPSNSEAKRRISFFAQSLATPISEPV PVDCMPTFTVLVPHYSEKILLGLKEIIREESPKSKITVLEYLKHLHPTEWECFVKDTKLL SMEKSFLKEAESSHDEDRLEIPDALYDPRSSPLSDHTESRKLPTEDDLIKEKINDLPFSY FGFNSSEPSYTLRTRIWASLRTQTLYRTLSGFMNYSKAIKLLYRIENPSLVSLYRGNNEA LENDLENMASRKFRMVVAMQRYAKFNKDEVEATELLLRAYPNMFISYLLEELEQNESEKT YYSCLTNGYAEFDEESGLRKPIFKIRLSGNPILGDGKSDNQNHSIIFYRGEYIQVIDANQ DNYLEECLKIRSVLSEFEELELNPTIPYIPGIEYEEEPPPIAIVGSREYIFSENIGVLGD IAAGKEQTFGTLFARTLAEIGGKLHYGHPDFLNGIFMTTRGGLSKAQRGLHLNEDIYAGM NAICRGGKIKHSDYYQCGKGRDLGFGSILNFTTKIGAGMGEQLLSREYYYLGTQLPMDRF LSFFYAHPGFHLNNLFISFSVQLFFVLLLNLGALNHEIIACFYDKDAPITNLETPVGCYN IQPALHWVSIFVLSIFIVFFIAFAPLLIQEVLEKGIWRAASRFLHHLLSMAPLFEVFVCQ VYSNSLLMDLTFGGAKYISTGRGFAITRLDFFTLYSRFVNISIYSGFQVFFMLLFAIISM WQPALLWFWITVISMCFAPFIFNPHQFAFMDFFIDYKTFIHWLFSGNTKYQKESWANFVK SSRSRFTGYKSKTVDDISEDSGHDSKKARFWNVFFAELFLPFCVFLFNFTAFSFINAQTG VSDSTPTSAVFRLLLVTFLPIFLNSIVLFLLFWVSLFVVPGLSYCCKDAGAVIAFIAHTF SVLVYLLDFELMWFLQGWNFTRTLILLITCINMHLILFKVFTTIFLTREYKNNKAHLAWW NGKWYNTGMGWSIILQPIREYFVKIMESSYFAADFFLGHFLLFIQTPIILLPFIDYWHTM VLFWMNPRSIIAHKRILTRKQRALRSRIVSKYFSLYFVMLGVLLFMLIAPFFAGDFVSSP QELLEGTLFEGIFQPNNQNNNDTGPNAPSTILTTTPTLPTFRTVA
References
External Links
ResourceLink
Saccharomyces Genome Database FKS3
Uniprot IDQ04952
Uniprot NameFKS3_YEAST
GenBank Gene IDZ49212
Genebank Protein ID798948
General Reference
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278
  • Reinders, J., Zahedi, R. P., Pfanner, N., Meisinger, C., Sickmann, A. (2006). "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res 5:1543-1554.16823961
  • Ishihara, S., Hirata, A., Nogami, S., Beauvais, A., Latge, J. P., Ohya, Y. (2007). "Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae." Eukaryot Cell 6:143-156.17158736
  • Kung, L. A., Tao, S. C., Qian, J., Smith, M. G., Snyder, M., Zhu, H. (2009). "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Mol Syst Biol 5:308.19756047