Serine/threonine-protein kinase STE20 (Q03497)

Identification
NameSerine/threonine-protein kinase STE20
SynonymsNot Available
Gene NameSTE20
Enzyme ClassNot Available
Biological Properties
General Functionvacuole inheritance
Specific FunctionMAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
ATP binding
osmosensory signaling pathway via Sho1 osmosensor
pheromone-dependent signal transduction involved in conjugation with cellular fusion
negative regulation of gene expression
nucleus
negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter
cytoplasm
sterol import
incipient cellular bud site
histone kinase activity (H2B-S14 specific)
mating projection tip
MAP kinase kinase kinase kinase activity
invasive growth in response to glucose limitation
activation of MAPKKK activity
protein phosphorylation
positive regulation of apoptotic process
pseudohyphal growth
stress granule assembly
signal transduction involved in filamentous growth
cellular response to heat
regulation of exit from mitosis
identical protein binding
budding cell apical bud growth
vacuole inheritance
bipolar cellular bud site selection
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2820 bp ATGAGCAATGATCCATCTGCTGTATCGGAACTACCAGACAAGGACAGTCTTGATAACGGT ATCAGCAATGACAATGAAAGGGCCATGGGCGGCAATGGCGATGGCGGCGATGGATTACGA TTACCAAGGACCACTGGAACTTTGAACGTCAATGCCTTACAAAAAGGCACTAATGCTGCC CATGAAGCTGGTGGATACAAATCCATGGATCCTGCGAAGAACGCGGAGACAACCAATGAT GATGACAATAATGTCGTTTCACTAGATGATCCTATTCAATTTACCCGAGTATCTTCCTCC TCTGTCATCAGTGGAATGTCTTCATCCATGAGTCCTCATTCTAACATCGATGAAACCAAA TCTCTAGAAGCAGTCACTCCAAACATAAATACCAGCAATATAACCCCGGATCATTCTGCT GACAACACATTTTCTACCATAAATGCGTCCGAGTCAGATCACCAGTTTAATGACACTTTA CTATCAAAACTGTCGTTAACAGATTCTACAGAAACTATAGAAAATAACGCGACAGTGAAG CACCAGCAGCCAGTTGCATCTTCCACAGTAAACTCGAATAAGAGCTCCACTGATATACGA AGGGCTACACCAGTGTCCACTCCCGTTATCTCTAAACCATCGATGACAACCACGCCAAGA CAGATCAATTCAGCTTCCCATTCGCTTTCGAACCCTAAGCATAAGCAACATAAACCAAAA GTTAAACCGTCCAAGCCTGAAGCAAAAAGTAAACCGGTTTCTGTGAAAAAAAGCTTTCCT TCGAAAAATCCTTTAAAAAACTCCTCTCCACCTAAAAAGCAAACAGAAAAATCGTATTAT TCTTCCTCTTCGAAAAAAAGGAAAAGCGGTTCAAATAGTGGTACACTAAGAATGAAAGAT GTCTTTACGTCCTTTGTACAGAATATAAAGAGAAATTCTCAGGATGATAAAAGGGCCTCA TCGTCGTCCAATAATTCTTCCTCATCTTCTATAACCACCGCTTTGAGGATATCTACGCCA TACAATGCCAAGCATATCCACCATGTGGGCGTGGACTCCAAGACTGGTGAGTACACAGGT TTGCCGGAGGAATGGGAAAAATTGTTGACTTCTAGTGGTATTTCCAAAAGAGAACAACAG CAAAACATGCAAGCAGTCATGGATATTGTCAAATTCTATCAGGATGTCACGGAAACAAAC GGTGAAGATAAAATGTTCAAGACTTTCAACACAACCACAGGATTGCCGGGAAGTCCTCAA GTTTCAACACCGCCTGCAAACTCATTCAATAAATTTCCTCCGTCGACAAGTGATTCGCAC AATTACGGTTCCAGAACAGGTACACCAATGTCCAATCACGTCATGTCTCCAACCTTAAAT ACAGATTCTAGTTCAGCAAACGGGAAATTCATACCAAGTAGACCGGCTCCTAAGCCCCCA TCTTCTGCGTCCGCTTCAGCTCCAATTATAAAATCACCCGTCATGAATTCTGCCGCCAAT GTTTCGCCCTTGAAGCAGACTCATGCACCTACAACTCCGAACAGGACCAGCCCAAACAGG TCCTCAATATCAAGAAATGCCACTTTAAAAAAAGAGGAGCAGCCACTACCACCAATACCT CCAACCAAATCCAAAACGTCTCCAATCATCTCCACAGCTCACACACCACAGCAAGTTGCT CAATCGCCAAAAGCGCCGGCGCAAGAGACGGTAACGACACCTACTTCGAAGCCAGCTCAA GCAAGAAGCTTGTCTAAAGAATTAAATGAGAAAAAGAGAGAGGAAAGGGAAAGACGTAAA AAACAACTATATGCCAAATTGAACGAAATTTGCTCAGACGGTGACCCAAGTACAAAATAT GCCAATTTAGTAAAAATTGGTCAAGGTGCATCAGGTGGTGTTTATACTGCTTATGAAATA GGTACGAATGTCTCAGTGGCCATTAAGCAAATGAATCTCGAAAAGCAACCAAAAAAGGAG CTAATCATCAATGAGATTCTGGTCATGAAGGGTAGCAAACACCCTAATATAGTTAATTTC ATTGATTCTTACGTTTTAAAAGGCGACCTTTGGGTCATTATGGAATACATGGAAGGTGGC TCCTTAACTGATGTGGTCACCCATTGTATTTTGACAGAAGGTCAAATTGGTGCCGTTTGT AGAGAAACTTTGAGTGGGTTGGAATTTTTACATTCTAAAGGTGTTCTTCACAGAGATATC AAATCCGATAACATCCTATTGTCCATGGAAGGGGATATTAAGTTAACGGATTTCGGTTTT TGCGCTCAAATCAATGAATTGAACTTGAAAAGAACTACTATGGTGGGAACGCCTTATTGG ATGGCGCCTGAAGTGGTTTCTAGGAAAGAATATGGCCCAAAAGTAGATATCTGGTCGTTG GGTATCATGATCATTGAAATGATCGAGGGGGAGCCTCCATATTTAAATGAAACCCCGCTA AGAGCACTGTATTTAATTGCTACAAATGGTACACCCAAGTTAAAGGAACCCGAGAATCTA TCGTCAAGCTTGAAAAAATTCCTTGATTGGTGTTTATGTGTGGAGCCCGAAGATAGAGCA AGCGCTACGGAATTGCTTCATGATGAATATATCACGGAGATAGCTGAAGCCAATTCCTCA TTGGCCCCGCTAGTCAAGTTAGCAAGATTGAAGAAAGTAGCTGAGAACATGGATGCTGAT GAAGATAATGACGACGATAACGACAACGAGCATATTAATAAGACAAACAATTGTGACGAC AATAACGATAGCAAAGAAACCGTAAATTTGGACGTAACTGAAGATGATAAACAAAAGTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues939
Protein Molecular Weight102361.32
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Serine/threonine-protein kinase STE20 MSNDPSAVSELPDKDSLDNGISNDNERAMGGNGDGGDGLRLPRTTGTLNVNALQKGTNAA HEAGGYKSMDPAKNAETTNDDDNNVVSLDDPIQFTRVSSSSVISGMSSSMSPHSNIDETK SLEAVTPNINTSNITPDHSADNTFSTINASESDHQFNDTLLSKLSLTDSTETIENNATVK HQQPVASSTVNSNKSSTDIRRATPVSTPVISKPSMTTTPRQINSASHSLSNPKHKQHKPK VKPSKPEAKSKPVSVKKSFPSKNPLKNSSPPKKQTEKSYYSSSSKKRKSGSNSGTLRMKD VFTSFVQNIKRNSQDDKRASSSSNNSSSSSITTALRISTPYNAKHIHHVGVDSKTGEYTG LPEEWEKLLTSSGISKREQQQNMQAVMDIVKFYQDVTETNGEDKMFKTFNTTTGLPGSPQ VSTPPANSFNKFPPSTSDSHNYGSRTGTPMSNHVMSPTLNTDSSSANGKFIPSRPAPKPP SSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNATLKKEEQPLPPIP PTKSKTSPIISTAHTPQQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREERERRK KQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKE LIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVC RETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYW MAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENL SSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVKLARLKKVAENMDAD EDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTEDDKQK
References
External Links
ResourceLink
Saccharomyces Genome Database STE20
Uniprot IDQ03497
Uniprot NameSTE20
PDB ID
2KYM
General ReferenceNot Available