Vacuolar protein sorting-associated protein 30 (Q02948)
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| Name | Vacuolar protein sorting-associated protein 30 | |||||||||||||||||||||
| Synonyms |
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| Gene Name | VPS30 | |||||||||||||||||||||
| Enzyme Class | Not Available | |||||||||||||||||||||
| Biological Properties | ||||||||||||||||||||||
| General Function | retrograde transport, endosome to Golgi | |||||||||||||||||||||
| Specific Function | Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth. | |||||||||||||||||||||
| Cellular Location | Not Available | |||||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | |||||||||||||||||||||
| SMPDB Reactions |
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| KEGG Reactions | Not Available | |||||||||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | ||||||||||||||||||||||
| Chromosome Location | Not Available | |||||||||||||||||||||
| Locus | ||||||||||||||||||||||
| Gene Sequence | >1674 bp ATGAAGTGCCAAACATGTCACTTACCCCTGCAACTAGACCCATCTTTAGAAGGTCTTAGT TTAACCCAAAGAAATTTGCTACTTTCAAATAATTCAATTATCACTGCAACGAATGAAAAT GTCATCAGCAACAAGGGCATCGAAGCCGCAGATAATTGTGGGCCTCAAATACCGAAGGAG AGGCTGAGGCGATTAGGGGAGATTCAGAACATAAAAGACTTGAATTTAAAAGATGATAAA TTAATCACTGATTCGTTTGTTTTTCTTAATCACGATGATGATGATAATGCTAATATTACG AGTAATAGCAGAGAGGACCAGCGTTATGGAAATGCCAACGGAAATGATAATAAAAAAGCT AATAGTGATACTTCCGATGGAACCAGTACCTTTCGAGATCATGACGAAGAGGAACAAGAA GCTACGGATGAGGACGAAAACCAACAAATACAATTGAATTCCAAGACTTTGTCCACACAA GTCAACGCAATGACTAATGTATTTAACATTCTATCTTCTCAAACAAACATAGACTTTCCT ATCTGTCAGGACTGCTGTAACATCTTGATAAACAGACTAAAAAGTGAGTATGATGATGCA ATAAAAGAGAGAGATACTTACGCTCAATTTTTATCGAAGTTAGAGAGTCAAAACAAAGAA ATATCAGAAAGCAATAAAGAAAAGCAGTATTCCCATAATCTTTCGGAAAAAGAAAATTTG AAAAAGGAAGAGGAAAGACTCTTGGATCAATTATTACGTTTGGAAATGACAGATGATGAC TTAGATGGAGAACTAGTTCGTTTACAAGAAAAGAAAGTTCAACTGGAAAATGAGAAACTC CAAAAACTGAGTGATCAGAATTTAATGGATTTAAATAACATTCAATTCAACAAAAATTTA CAGTCATTAAAACTGCAATACGAATTATCCTTGAATCAATTAGATAAGTTGAGGAAAATC AATATTTTCAATGCTACATTCAAAATCTCACATAGCGGCCCCTTTGCCACTATAAATGGA TTGAGATTAGGCAGTATACCAGAATCAGTGGTACCTTGGAAGGAAATCAATGCAGCACTG GGCCAATTGATTCTTTTACTGGCTACCATAAACAAAAACCTGAAGATAAATTTAGTAGAC TACGAATTACAACCGATGGGTTCATTTTCCAAAATCAAGAAAAGAATGGTTAACAGTGTC GAATATAATAATTCCACTACGAACGCTCCCGGTGATTGGTTGATTCTGCCTGTCTACTAT GATGAGAATTTCAATTTGGGGAGAATCTTCCGCAAGGAAACGAAGTTTGATAAATCATTA GAAACAACATTAGAAATAATAAGCGAAATCACTCGGCAGCTTTCTACGATAGCGTCATCA TATTCATCTCAAACACTCACAACAAGCCAAGATGAATCTTCAATGAATAACGCAAATGAC GTTGAAAATAGTACTTCCATTCTCGAGCTACCCTATATCATGAATAAGGACAAGATTAAT GGATTATCCGTCAAATTGCATGGTAGCAGTCCCAACCTTGAATGGACAACGGCTATGAAA TTTTTATTAACCAATGTAAAGTGGTTGTTAGCGTTTTCTTCCAATTTACTATCCAAGTCA ATTACCTTAAGCCCTACAGTGAATTACAATGATAAGACCATCAGCGGAAACTAA | |||||||||||||||||||||
| Protein Properties | ||||||||||||||||||||||
| Pfam Domain Function | Not Available | |||||||||||||||||||||
| Protein Residues | 557 | |||||||||||||||||||||
| Protein Molecular Weight | 63260.22 | |||||||||||||||||||||
| Protein Theoretical pI | Not Available | |||||||||||||||||||||
| PDB File | show | |||||||||||||||||||||
| Signalling Regions | Not Available | |||||||||||||||||||||
| Transmembrane Regions | Not Available | |||||||||||||||||||||
| Protein Sequence | >Vacuolar protein sorting-associated protein 30 MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKE RLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKA NSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFP ICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENL KKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNL QSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAAL GQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYY DENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNAND VENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKS ITLSPTVNYNDKTISGN | |||||||||||||||||||||
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| General Reference | Not Available | |||||||||||||||||||||