Protein MLP1 (Q02455)
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| Name | Protein MLP1 | |||||||||||||||
| Synonyms |
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| Gene Name | MLP1 | |||||||||||||||
| Enzyme Class | Not Available | |||||||||||||||
| Biological Properties | ||||||||||||||||
| General Function | transcriptional activation by promoter-terminator looping | |||||||||||||||
| Specific Function | Involved together with the closely related MLP2 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP1 also recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself. | |||||||||||||||
| Cellular Location | Not Available | |||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | |||||||||||||||
| SMPDB Reactions | Not Available | |||||||||||||||
| KEGG Reactions | Not Available | |||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | ||||||||||||||||
| Chromosome Location | Not Available | |||||||||||||||
| Locus | ||||||||||||||||
| Gene Sequence | >5628 bp ATGTCGGATCATGATACTCCAATGGAAAGCATACAAAATGGTGAAAATTCAGACGAAAGA TTGAACGCCATTGCGTCTTTTTTCGGTTGCTCTTTAGAGCAGGTTAAATCATTTGACGGT GATGTGGTAAAACACCTTAACGATAAACTTTTACAGTTTAATGAACTTAAATCGGAGAAT CTAAAGGTTACCGTCTCATTCGATGAATTGAAGGCTAGTTCTTTAAAGAAAATTGATGGT TTGAAGACAGAAATGGAAAACGTTATAAGAGAAAATGATAAAATCCGAAAAGAGAGGAAT GATACTTTTGTTAAGTTCGAATCTGTAGAAAATGAAAAGATGAAATTATCAAGTGAGCTA GAGTTTGTGAAAAGGAAGCTCGATGATTTAACTGAGGAGAAAAAGGAAACCCAGAGTAAT CAACAGCGAACCCTGAAAATACTGGATGAAAGACTAAAAGAAATAGAATTGGTCAGGGTT GAGAATAATCGCTCCAATAGTGAATGTAAGAAACTACGCTCTACAATAATGGATTTAGAA ACAAAACAACAGGGCTATATTACTAATGACCTGAATTCTAGAACTGAACTGGAAAGAAAA ACACAAGAATTGACTTTATTGCAGTCAAATAATGATTGGCTAGAAAAGGAGCTACGTTCA AAAAATGAACAGTATCTCTCCTACAGACAAAAAACCGACAAAGTAATTCTAGATATCAGG AATGAATTAAATCGTTTAAGGAATGATTTTCAAATGGAAAGAACGAATAATGATGTTTTG AAGCAAAAAAATAACGAATTGTCAAAATCTTTACAAGAAAAACTACTGGAAATCAAGGGT CTATCCGACTCCCTAAATTCCGAAAAGCAAGAATTTTCTGCAGAAATGTCCCTAAAGCAA CGTTTAGTGGACCTTTTAGAATCACAATTGAACGCTGTAAAAGAAGAATTGAACAGTATA AGAGAGTTGAACACTGCAAAGGTAATAGCAGATGATTCAAAAAAACAAACTCCCGAAAAT GAAGACTTACTTAAGGAATTGCAGTTAACGAAAGAAAAATTAGCACAATGCGAAAAAGAA TGTCTACGTTTATCCTCTATAACTGACGAAGCAGATGAAGATAATGAAAATTTATCTGCA AAATCTAGTTCTGATTTTATATTCCTGAAGAAACAATTAATTAAAGAAAGGCGTACCAAG GAACATCTTCAAAATCAAATTGAAACATTCATCGTAGAGTTGGAACATAAAGTGCCCATT ATAAACTCTTTCAAAGAAAGAACTGACATGTTGGAAAACGAATTGAATAACGCTGCATTG TTACTAGAGCATACATCGAACGAGAAGAATGCAAAGGTTAAGGAATTAAATGCCAAAAAC CAAAAGCTAGTGGAATGTGAAAATGATCTTCAAACTTTAACTAAACAACGTCTCGATCTA TGCCGTCAAATACAATACCTTTTAATTACCAATTCTGTTTCTAATGACTCGAAGGGACCC TTACGTAAGGAAGAAATTCAATTTATTCAAAACATTATGCAGGAAGACGATAGTACTATC ACAGAATCTGACTCTCAAAAAGTCGTAACTGAAAGACTAGTTGAATTCAAAAACATTATT CAATTACAAGAAAAAAATGCAGAACTTTTGAAAGTAGTAAGAAACTTAGCCGATAAGTTG GAATCGAAAGAAAAGAAATCTAAACAAAGTCTTCAGAAAATCGAAAGTGAAACAGTAAAT GAGGCTAAAGAGGCTATAATAACTTTAAAGAGTGAAAAAATGGATCTAGAATCAAGAATT GAGGAACTACAGAAAGAGCTTGAAGAATTGAAAACTTCTGTTCCCAACGAAGATGCGTCA TACAGCAATGTAACTATAAAACAGTTAACCGAAACTAAGAGAGACCTCGAATCTCAAGTA CAAGACTTGCAAACTCGTATCTCGCAAATTACTAGGGAGTCTACTGAAAATATGTCACTT TTAAACAAGGAGATACAGGACCTGTATGACAGCAAGAGCGACATATCCATTAAGCTTGGA AAGGAAAAATCATCGAGAATATTGGCAGAGGAACGATTTAAACTACTTTCGAATACGTTA GATCTAACTAAAGCTGAGAACGACCAACTGCGCAAAAGGTTTGATTATTTACAGAATACT ATTTTAAAACAAGATTCCAAAACACACGAGACACTTAATGAATACGTTTCCTGTAAATCT AAGTTAAGCATTGTTGAAACAGAATTATTGAACCTGAAAGAAGAACAGAAATTAAGAGTT CATTTAGAAAAGAACTTGAAACAAGAACTGAATAAACTCTCCCCTGAAAAGGACAGTTTA CGCATCATGGTAACTCAATTACAAACTTTACAAAAGGAGCGTGAAGATCTATTGGAAGAG ACTAGGAAATCATGTCAAAAGAAAATAGATGAACTTGAAGATGCTCTCAGCGAACTTAAA AAGGAAACTTCTCAAAAAGACCATCATATCAAACAGCTGGAAGAAGACAACAATTCAAAT ATAGAATGGTACCAAAATAAAATCGAAGCTTTGAAGAAAGATTATGAATCAGTAATAACT TCTGTAGATAGTAAGCAAACTGACATTGAGAAATTACAATATAAAGTCAAATCACTAGAA AAGGAAATCGAGGAGGACAAGATTCGTTTACATACTTATAATGTTATGGATGAAACAATT AACGATGATTCCCTACGCAAGGAGTTGGAAAAATCCAAGATTAACTTAACTGATGCTTAT TCACAAATCAAAGAATACAAGGATCTCTACGAGACTACCTCTCAGTCTTTGCAGCAAACG AATTCTAAATTGGATGAATCTTTCAAGGACTTTACTAACCAGATTAAAAACCTAACTGAT GAAAAAACTAGTTTGGAGGATAAGATTTCGCTTCTAAAAGAGCAAATGTTTAATTTGAAT AATGAGCTAGATTTGCAGAAAAAAGGGATGGAAAAAGAAAAAGCTGACTTTAAGAAAAGG ATATCAATTTTACAGAACAATAATAAAGAAGTCGAAGCTGTTAAGTCCGAATATGAATCG AAGTTATCAAAAATCCAAAACGACCTTGATCAACAAACTATATATGCTAATACTGCGCAA AACAACTATGAACAAGAACTACAGAAACATGCAGATGTTTCTAAGACGATTAGTGAATTA AGAGAGCAATTACATACGTACAAAGGTCAAGTTAAGACCCTGAACTTATCGCGTGATCAA CTGGAGAATGCTCTGAAAGAAAACGAAAAGAGTTGGTCCTCCCAGAAGGAATCTTTATTA GAACAGCTAGATTTATCGAATTCTCGTATTGAGGATTTATCCTCCCAAAATAAACTATTG TATGATCAAATACAAATCTACACAGCTGCGGACAAAGAAGTCAATAATTCGACAAACGGA CCTGGTTTGAATAATATTTTAATTACACTACGTCGCGAAAGGGATATTCTTGATACAAAA GTGACGGTGGCTGAAAGAGATGCAAAAATGTTGAGACAAAAAATTTCTTTGATGGATGTT GAATTACAAGATGCTCGTACTAAGCTAGATAATTCAAGAGTTGAAAAGGAAAATCATTCT TCCATTATTCAACAGCATGACGACATTATGGAGAAATTAAATCAATTAAATCTATTAAGA GAAAGTAACATAACATTGCGGAATGAGCTGGAAAACAACAATAACAAGAAGAAGGAACTG CAATCTGAATTAGATAAATTGAAGCAAAATGTTGCGCCTATCGAGTCCGAATTGACAGCC TTGAAATATTCTATGCAAGAAAAAGAGCAAGAGCTCAAATTAGCTAAAGAAGAGGTTCAT CGTTGGAAAAAGCGCTCACAAGACATATTGGAGAAACATGAACAATTGAGCTCAAGCGAT TATGAGAAGCTAGAAAGCGAGATAGAAAATTTGAAGGAGGAACTAGAAAATAAGGAGCGT CAAGGAGCGGAAGCCGAGGAAAAATTTAACAGGCTGAGAAGACAAGCGCAAGAGAGATTA AAAACATCAAAACTCTCACAGGACTCATTGACTGAACAAGTAAATAGTCTAAGGGATGCA AAGAACGTGTTGGAAAATTCCTTGAGTGAGGCAAACGCGAGAATCGAAGAGTTACAAAAT GCAAAAGTAGCACAAGGTAACAACCAGTTAGAAGCAATAAGAAAATTACAAGAAGACGCA GAAAAGGCTTCAAGAGAGCTTCAAGCCAAGTTAGAAGAAAGTACGACTTCTTACGAATCT ACGATAAACGGCTTAAATGAAGAGATTACAACATTAAAAGAAGAAATTGAAAAACAAAGG CAAATCCAGCAACAGTTACAAGCTACATCTGCAAATGAACAAAATGACTTATCTAACATA GTTGAGTCTATGAAAAAGTCTTTTGAAGAAGATAAAATCAAATTCATCAAAGAAAAAACC CAAGAAGTTAATGAAAAAATACTCGAGGCCCAAGAAAGGCTAAATCAACCTTCCAATATC AATATGGAGGAGATTAAAAAAAAATGGGAATCTGAGCACGAACAGGAAGTATCTCAAAAG ATTCGCGAAGCTGAGGAAGCCCTCAAAAAGCGAATCAGATTACCCACTGAGGAGAAAATT AATAAGATAATCGAACGAAAGAAGGAGGAATTGGAAAAAGAGTTTGAAGAAAAGGTTGAG GAGAGAATAAAATCAATGGAACAATCTGGAGAAATAGACGTGGTGCTTCGAAAACAGCTA GAAGCTAAGGTTCAAGAGAAACAAAAGGAATTGGAAAACGAGTATAACAAAAAATTACAA GAAGAACTCAAAGATGTACCACACTCAAGTCATATCTCAGATGATGAAAGGGACAAATTA CGAGCAGAAATCGAAAGCAGGTTGAGGGAGGAGTTCAACAATGAACTGCAAGCCATAAAG AAGAAATCCTTCGACGAAGGAAAGCAACAAGCAATGATGAAAACTACCCTTTTGGAAAGA AAACTTGCCAAGATGGAATCTCAATTGTCAGAAACAAAACAAAGTGCCGAGAGTCCTCCG AAATCTGTTAACAATGTACAAAATCCATTACTAGGATTACCTAGGAAAATCGAAGAGAAT TCAAATTCACCATTCAATCCGTTACTTTCCGGTGAAAAACTCTTAAAGCTAAATTCTAAG TCTTCATCAGGTGGATTTAACCCTTTTACCTCGCCATCCCCAAATAAGCACTTACAAAAT GATAATGACAAAAGGGAGTCGTTGGCTAACAAGACAGATCCACCAACTCATTTGGAACCC AGCTTCAACATTCCCGCCTCAAGGGGTCTAATATCTTCATCTTCCACTTTGTCAACTGAT ACAAATGATGAAGAACTTACTAGCAACAATCCTGCCCAAAAGGATTCATCGAACAGAAAT GTTCAATCGGAAGAGGATACAGAAAAAAAGAAAGAGGGAGAACCTGTTAAAAGAGGAGAG GCAATAGAAGAGCAGACGAAATCCAACAAGCGACCTATTGATGAGGTAGGAGAGCTGAAA AATGATGAAGACGACACTACAGAAAACATTAATGAGTCAAAAAAGATCAAGACTGAAGAT GAGGAAGAAAAAGAAACCGATAAGGTGAATGACGAGAACAGTATATAA | |||||||||||||||
| Protein Properties | ||||||||||||||||
| Pfam Domain Function | Not Available | |||||||||||||||
| Protein Residues | 1875 | |||||||||||||||
| Protein Molecular Weight | 218454.4 | |||||||||||||||
| Protein Theoretical pI | Not Available | |||||||||||||||
| Signalling Regions | Not Available | |||||||||||||||
| Transmembrane Regions | Not Available | |||||||||||||||
| Protein Sequence | >Protein MLP1 MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSEN LKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSEL EFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLE TKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIR NELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQ RLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKE CLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPI INSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDL CRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNII QLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRI EELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSL LNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNT ILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSL RIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSN IEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETI NDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTD EKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYES KLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQ LENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNG PGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHS SIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTA LKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKER QGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQN AKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQR QIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNI NMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVE ERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKL RAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPP KSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQN DNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRN VQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTED EEEKETDKVNDENSI | |||||||||||||||
| References | ||||||||||||||||
| External Links |
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| General Reference | Not Available | |||||||||||||||