| Identification |
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| Name | Geranylgeranyl transferase type-2 subunit alpha |
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| Synonyms | - GGTase-II-alpha
- Geranylgeranyl transferase type II subunit alpha
- PGGT
- Type II protein geranyl-geranyltransferase subunit alpha
- YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
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| Gene Name | BET4 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in protein prenyltransferase activity |
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| Specific Function | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 |
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| Cellular Location | Not Available |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00219 | Pyrophosphate | Show | | YMDB00359 | 2-trans,6-trans,10-trans-geranylgeranyl diphosphate | Show | | YMDB00631 | geranylgeranyl diphosphate | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| catalytic activity | | transferase activity | | transferase activity, transferring alkyl or aryl (other than methyl) groups | | prenyltransferase activity | | protein prenyltransferase activity | | Process |
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| metabolic process | | macromolecule metabolic process | | macromolecule modification | | protein modification process | | protein amino acid lipidation | | protein prenylation | | protein amino acid prenylation |
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| Gene Properties |
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| Chromosome Location | chromosome 10 |
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| Locus | YJL031C |
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| Gene Sequence | >YJL031C BET4 SGDID:S000003568, Chr X from 387438-386368, reverse complement, Verified ORF, "Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment
ATGGTATGTGCACTTCAAATGTTCGTTACATTATGAATTCTTTTTTTTACTGACTACCAA
GCAATTTTTTATATTTGCCACATTAAACAGCATGGCATTAAAAGGAAACAGTGGACCAAG
GAATTACTGAGACAAAAGAGAGTTCAAGACGAAAAGAAAATATATGATTATAGAAGCTTG
ACTGAAAATGTTTTGAATATGAGAGATGAAAAAATTTACTCAATTGAAGCTCTGAAGAAA
ACATCAGAACTTCTTGAGAAAAATCCGGAATTTAATGCTATTTGGAATTACAGAAGGGAT
ATTATAGCGAGTTTGGCTTCTGAGTTGGAAATACCTTTCTGGGATAAAGAGTTAGTTTTT
GTAATGATGCTATTGAAGGATTACCCCAAAGTCTATTGGATATGGAATCACAGACTTTGG
GTCTTGAAACATTATCCTACGAGTTCCCCTAAAGTGTGGCAAACTGAACTTGCTGTCGTG
AATAAGTTATTGGAACAAGATGCAAGAAATTACCACGGATGGCATTACCGCAGAATAGTT
GTTGGTAACATAGAGAGTATCACTAATAAAAGTCTTGACAAGGAGGAGTTTGAATACACA
ACAATAAAGATTAACAATAACATTTCAAATTATTCTGCATGGCACCAAAGAGTACAGATC
ATAAGCAGAATGTTTCAGAAAGGAGAGGTTGGGAATCAAAAGGAGTATATTCGGACTGAA
ATATCTTATATCATCAACGCTATGTTTACCGACGCCGAAGACCAATCCGTATGGTTTTAT
ATCAAGTGGTTCATTAAAAACGACATTGTTTGTAAAACTCTGGACGAACAAGAGTACCTT
AAAATGTTGAAAGACTTGAGAGAAAACATTCTGTTAATAAATAATGACGAAATTGAATTT
TCCGGGAAGCAAAATATTTGGTGCTTGAAAATTTTATTAGTTCTCGAAGATATTCTGGAA
GAAAAGGAAGCTCTAACGGAAAGAAGCTCGGAACAATATTTGGTCCAATTAATAGATGCG
GATCCGTTAAGAAAGAATAGATACCTACATCTCCTGGAGCAGCATAAGTGA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 327 |
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| Protein Molecular Weight | 39674.30078 |
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| Protein Theoretical pI | 7.27 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Geranylgeranyl transferase type-2 subunit alpha
MHGIKRKQWTKELLRQKRVQDEKKIYDYRSLTENVLNMRDEKIYSIEALKKTSELLEKNP
EFNAIWNYRRDIIASLASELEIPFWDKELVFVMMLLKDYPKVYWIWNHRLWVLKHYPTSS
PKVWQTELAVVNKLLEQDARNYHGWHYRRIVVGNIESITNKSLDKEEFEYTTIKINNNIS
NYSAWHQRVQIISRMFQKGEVGNQKEYIRTEISYIINAMFTDAEDQSVWFYIKWFIKNDI
VCKTLDEQEYLKMLKDLRENILLINNDEIEFSGKQNIWCLKILLVLEDILEEKEALTERS
SEQYLVQLIDADPLRKNRYLHLLEQHK |
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| References |
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| External Links | |
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| General Reference | - Li, R., Murray, A. W. (1991). "Feedback control of mitosis in budding yeast." Cell 66:519-531.1651172
- Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
- Brachat, S., Dietrich, F. S., Voegeli, S., Zhang, Z., Stuart, L., Lerch, A., Gates, K., Gaffney, T., Philippsen, P. (2003). "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Genome Biol 4:R45.12844361
- Li, R., Havel, C., Watson, J. A., Murray, A. W. (1993). "The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase." Nature 366:82-84.8232541
- Jiang, Y., Rossi, G., Ferro-Novick, S. (1993). "Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p." Nature 366:84-86.8232542
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