Geranylgeranyl transferase type-2 subunit alpha (Q00618)

Identification
NameGeranylgeranyl transferase type-2 subunit alpha
Synonyms
  • GGTase-II-alpha
  • Geranylgeranyl transferase type II subunit alpha
  • PGGT
  • Type II protein geranyl-geranyltransferase subunit alpha
  • YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene NameBET4
Enzyme Class
Biological Properties
General FunctionInvolved in protein prenyltransferase activity
Specific FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00219PyrophosphateShow
YMDB003592-trans,6-trans,10-trans-geranylgeranyl diphosphateShow
YMDB00631geranylgeranyl diphosphateShow
GO Classification
Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
prenyltransferase activity
protein prenyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid lipidation
protein prenylation
protein amino acid prenylation
Gene Properties
Chromosome Locationchromosome 10
LocusYJL031C
Gene Sequence>YJL031C BET4 SGDID:S000003568, Chr X from 387438-386368, reverse complement, Verified ORF, "Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment ATGGTATGTGCACTTCAAATGTTCGTTACATTATGAATTCTTTTTTTTACTGACTACCAA GCAATTTTTTATATTTGCCACATTAAACAGCATGGCATTAAAAGGAAACAGTGGACCAAG GAATTACTGAGACAAAAGAGAGTTCAAGACGAAAAGAAAATATATGATTATAGAAGCTTG ACTGAAAATGTTTTGAATATGAGAGATGAAAAAATTTACTCAATTGAAGCTCTGAAGAAA ACATCAGAACTTCTTGAGAAAAATCCGGAATTTAATGCTATTTGGAATTACAGAAGGGAT ATTATAGCGAGTTTGGCTTCTGAGTTGGAAATACCTTTCTGGGATAAAGAGTTAGTTTTT GTAATGATGCTATTGAAGGATTACCCCAAAGTCTATTGGATATGGAATCACAGACTTTGG GTCTTGAAACATTATCCTACGAGTTCCCCTAAAGTGTGGCAAACTGAACTTGCTGTCGTG AATAAGTTATTGGAACAAGATGCAAGAAATTACCACGGATGGCATTACCGCAGAATAGTT GTTGGTAACATAGAGAGTATCACTAATAAAAGTCTTGACAAGGAGGAGTTTGAATACACA ACAATAAAGATTAACAATAACATTTCAAATTATTCTGCATGGCACCAAAGAGTACAGATC ATAAGCAGAATGTTTCAGAAAGGAGAGGTTGGGAATCAAAAGGAGTATATTCGGACTGAA ATATCTTATATCATCAACGCTATGTTTACCGACGCCGAAGACCAATCCGTATGGTTTTAT ATCAAGTGGTTCATTAAAAACGACATTGTTTGTAAAACTCTGGACGAACAAGAGTACCTT AAAATGTTGAAAGACTTGAGAGAAAACATTCTGTTAATAAATAATGACGAAATTGAATTT TCCGGGAAGCAAAATATTTGGTGCTTGAAAATTTTATTAGTTCTCGAAGATATTCTGGAA GAAAAGGAAGCTCTAACGGAAAGAAGCTCGGAACAATATTTGGTCCAATTAATAGATGCG GATCCGTTAAGAAAGAATAGATACCTACATCTCCTGGAGCAGCATAAGTGA
Protein Properties
Pfam Domain Function
Protein Residues327
Protein Molecular Weight39674.30078
Protein Theoretical pI7.27
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Geranylgeranyl transferase type-2 subunit alpha MHGIKRKQWTKELLRQKRVQDEKKIYDYRSLTENVLNMRDEKIYSIEALKKTSELLEKNP EFNAIWNYRRDIIASLASELEIPFWDKELVFVMMLLKDYPKVYWIWNHRLWVLKHYPTSS PKVWQTELAVVNKLLEQDARNYHGWHYRRIVVGNIESITNKSLDKEEFEYTTIKINNNIS NYSAWHQRVQIISRMFQKGEVGNQKEYIRTEISYIINAMFTDAEDQSVWFYIKWFIKNDI VCKTLDEQEYLKMLKDLRENILLINNDEIEFSGKQNIWCLKILLVLEDILEEKEALTERS SEQYLVQLIDADPLRKNRYLHLLEQHK
References
External Links
ResourceLink
Saccharomyces Genome Database BET4
Uniprot IDQ00618
Uniprot NamePGTA_YEAST
General Reference
  • Li, R., Murray, A. W. (1991). "Feedback control of mitosis in budding yeast." Cell 66:519-531.1651172
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
  • Brachat, S., Dietrich, F. S., Voegeli, S., Zhang, Z., Stuart, L., Lerch, A., Gates, K., Gaffney, T., Philippsen, P. (2003). "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Genome Biol 4:R45.12844361
  • Li, R., Havel, C., Watson, J. A., Murray, A. W. (1993). "The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase." Nature 366:82-84.8232541
  • Jiang, Y., Rossi, G., Ferro-Novick, S. (1993). "Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p." Nature 366:84-86.8232542