D-arabinono-1,4-lactone oxidase (P54783)

Identification
NameD-arabinono-1,4-lactone oxidase
Synonyms
  • ALO
  • L-galactono-gamma-lactone oxidase
Gene NameALO1
Enzyme Class
Biological Properties
General FunctionInvolved in D-arabinono-1,4-lactone oxidase activity
Specific FunctionCan oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone
Cellular LocationMitochondrion membrane.
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
D-arabinono-1,4-lactone + oxygen ↔ Hydrogen peroxide + dehydro-D-arabinono-1,4-lactone
Metabolites
YMDB IDNameView
YMDB00014D-arabinono-1,4-lactoneShow
YMDB00192dehydro-D-arabinono-1,4-lactoneShow
YMDB00888Hydrogen peroxideShow
YMDB00900oxygenShow
GO Classification
Component
cell part
membrane
Function
D-arabinono-1,4-lactone oxidase activity
catalytic activity
binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
FAD or FADH2 binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
Process
metabolic process
biosynthetic process
oxidation reduction
Gene Properties
Chromosome Locationchromosome 13
LocusYML086C
Gene Sequence>1581 bp ATGTCTACTATCCCATTTAGAAAGAACTATGTGTTCAAAAACTGGGCCGGAATTTATTCT GCAAAACCAGAACGTTACTTCCAACCAAGTTCAATTGATGAGGTTGTCGAGTTAGTAAAG AGTGCCAGGCTAGCTGAAAAAAGCTTAGTTACTGTTGGTTCGGGCCATTCTCCTAGTAAC ATGTGCGTTACTGATGAATGGCTTGTTAACTTAGACAGATTGGACAAAGTACAAAAGTTT GTTGAATATCCTGAGTTACATTATGCCGATGTCACAGTTGATGCCGGTATGAGGCTTTAC CAATTGAATGAATTTTTGGGTGCGAAAGGTTACTCTATCCAAAATTTAGGCTCTATCTCA GAACAAAGTGTTGCTGGCATAATCTCTACTGGTAGTCATGGTTCCTCACCTTATCACGGT TTGATTTCTTCTCAATACGTAAACTTGACTATTGTTAATGGTAAGGGCGAATTGAAGTTC TTGGATGCCGAAAACGATCCAGAAGTCTTTAAAGCTGCTTTACTTTCAGTTGGAAAAATC GGTATCATTGTCTCTGCTACTATCAGGGTTGTTCCCGGCTTCAATATTAAATCCACTCAA GAAGTGATTACTTTTGAAAACCTTTTGAAGCAATGGGATACCCTATGGACTTCATCTGAA TTTATCAGAGTTTGGTGGTACCCTTATACTAGAAAATGTGTTCTATGGAGGGGTAACAAA ACTACAGATGCCCAAAATGGTCCAGCCAAGTCATGGTGGGGTACCAAGCTGGGTAGATTT TTCTACGAAACTCTATTATGGATCTCTACCAAAATCTATGCGCCATTAACCCCATTTGTG GAAAAGTTCGTTTTCAACAGGCAATACGGGAAATTGGAGAAGAGCTCTACTGGTGATGTT AATGTTACCGATTCTATCAGCGGATTTAATATGGACTGTTTGTTTTCACAATTTGTTGAT GAATGGGGGTGCCCTATGGATAATGGTTTGGAAGTCTTACGTTCATTGGATCATTCTATT GCGCAGGCTGCCATAAACAAAGAATTTTATGTCCACGTGCCTATGGAAGTCCGTTGCTCA AATACTACATTACCTTCTGAACCCTTGGATACTAGCAAGAGAACAAACACCAGTCCCGGT CCCGTTTATGGCAATGTGTGCCGCCCATTCCTGGATAACACACCATCCCATTGCAGATTT GCTCCGTTGGAAAATGTTACCAACAGTCAGTTGACGTTGTACATAAATCCTACCATTTAT AGGCCGTTTGGCTGTAATACTCCAATTCATAAATGGTTTACCCTTTTTGAAAATACTATG ATGGTAGCGGGAGGTAAGCCACATTGGGCCAAGAACTTCCTAGGCTCAACCACTCTAGCT GCTGGACCAGTGAAAAAGGATACTGATTACGATGACTTTGAAATGAGGGGGATGGCATTG AAGGTTGAAGAATGGTATGGCGAGGATTTGAAAAAGTTCCGGAAAATAAGAAAGGAGCAA GATCCCGATAATGTATTCTTGGCAAACAAACAGTGGGCTATCATAAATGGTATTATAGAT CCTAGTGAGTTGTCCGACTAG
Protein Properties
Pfam Domain Function
Protein Residues526
Protein Molecular Weight59493.19922
Protein Theoretical pI6.78
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>D-arabinono-1,4-lactone oxidase MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSN MCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSIS EQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKI GIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWWYPYTRKCVLWRGNK TTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDV NVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCS NTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIY RPFGCNTPIHKWFTLFENTMMVAGGKPHWAKNFLGSTTLAAGPVKKDTDYDDFEMRGMAL KVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD
References
External Links
ResourceLink
Saccharomyces Genome Database ALO1
Uniprot IDP54783
Uniprot NameALO_YEAST
GenBank Gene IDAB009401
Genebank Protein ID2696034
General Reference
  • Huh, W. K., Lee, B. H., Kim, S. T., Kim, Y. R., Rhie, G. E., Baek, Y. W., Hwang, C. S., Lee, J. S., Kang, S. O. (1998). "D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae." Mol Microbiol 30:895-903.10094636
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106