| Identification |
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| Name | Vitamin H transporter |
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| Synonyms | |
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| Gene Name | VHT1 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transmembrane transport |
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| Specific Function | Involved in uptake of biotin with the concomitant entry of protons |
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| Cellular Location | Cell membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00282 | Biotin | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| Not Available | | Process |
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| transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 7 |
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| Locus | YGR065C |
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| Gene Sequence | >1782 bp
ATGACAATTTCGAATAAATCGTGGAGGAGCTACTTCCCACATTTGAGAAAACTACCCGAA
GATGATCAGTACTTATACTCAGACGATACTAACTCCAGTATCATAGCTGAAGAGGAGCTA
CATCATAGCGTAGATAAGTCCTCGAAGACAGACGTTACGGCAGAAACTACAGCTGTAGAA
CCTCATCCTCACAATTTAAGGCATGACTTGCCATATGAAGTGAGAGATGAAGCTGGGCGT
AAATGGTGGAAATATTTTGATGAATTCGAGTATCGTGTTAATAAGGAATACAAGAAATCA
CGTAAGTGGTACGAGTTTTTGTATCCTAATCATACTACTCAAACCAAGGCTGAAAGACGG
CTTCTTTACAAGCTAGACATTATTATTGCTTTATACTTTTTTATGTTATGTTGGTCCAAG
TCAGTGGATTTGAATAACTACACTAACGCATATGTTTCCAATATGAAGGAAGATTTAAAC
ATGAAAGGTAATGATTACGTTTACACTTCTACTATTGCTAATGTTGGTGCCATTGTCTTC
CAATTACCATTTATGTATTTGTTACCAAGATTTCCCTCTCATATTATTTTGCCTGTAATG
GACTTGGGCTGGACTTGGTTCACATTTGCATGTTATAGGGCAAACTCACTAGCCGAACTA
AGGGCTTACAGATTTATTTTAAGTGCCTTTGGCGCTGCTTACTACCCAGTGTCCCAATAT
ATACTAGGTTGTTGGTATGCCCCAGATGAAATTAATTCAAGAGTCTGTTTATTCTTTTGT
GGGCAACAATTGGGTTCCGTGACTTCAGGACTTCTGCAAAGTCGCATATTCAAAAGTTTG
AACGGCGTCCATGGTCTAGCAGGCTGGAGATGGATGTTTCTGATCGATGCCATTGCAATT
TCTCTTCCCACGGCTATTATTGGTTTTTTTGTTATTCCCGGTGTACCATCTAAGTGTTAC
TCTTTATTTCTGACTGACGAAGAAATACGAATTGCAAGGGCCAGAAATAAGAGGAACCAA
ATCAAAGATGGTGTTGATAAAAGTAAGCTAGCCCCATTATGGAGCAGAAAACTTTGGAAG
AAAGTATTTTGTACTCCAGCATTCTGGGTACTTGTTGTTTTTGATACATGTTCGTGGAAT
AACATGACTGCGTATAGTGGTTCATATACTTTGTGGTTAAAGTCTAATACAAAGTACTCC
ATTGCCCAAGTGAACAACCTGAGTGTTATACCCGCATGTTTAGGATTTGCGTATGTGATT
TTTTGTGCCTTTGGTGCCGATTTATTTAGATGTAAGTGGATATTCATGGTTTTTGCTGCT
ATAATGAATACCGTTTCTTGTGCCTTACTTATCAAGTGGGATATTCCTTCGAAAGCTAAA
TGGTACGCTTTCTTCACCACGTATTTCAGTGTGGCCGCATCGCCTTGTCTATGGTCGTTT
ATTAATGACTTCTTAAGGTTTGATCCTCAGGTGAAGGCTATTACATGGATCGCCATTTAT
TCCTTCTCTCAATCCACTTACGCCTGGATTCCTACCTTGGCGTGGCCTACCGTGGAGTCA
CCACGTTTTAAGACTGGTTACACCGTGAGCTTAATTTTTGGTGCTATTTACGGTTTATGG
ACGTTTGTTGTACTTTTTTTTTACAAGAGAAACGAAAAGAAACATGCTCTAGGTAATGGT
ATCATCTTGTATGATAGTAATAAGGGTGAAGAGCTTCCAGAATTTGTAAAGAAAAATATG
GAGGAAAGAGATGGTTACTACTATTTAAAGCGGTCCTCGTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 593 |
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| Protein Molecular Weight | 69082.10156 |
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| Protein Theoretical pI | 9.07 |
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| Signalling Regions | |
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| Transmembrane Regions | - 122-142
- 167-187
- 191-211
- 225-245
- 292-312
- 362-382
- 409-429
- 433-453
- 461-481
- 493-513
- 527-547
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| Protein Sequence | >Vitamin H transporter
MTISNKSWRSYFPHLRKLPEDDQYLYSDDTNSSIIAEEELHHSVDKSSKTDVTAETTAVE
PHPHNLRHDLPYEVRDEAGRKWWKYFDEFEYRVNKEYKKSRKWYEFLYPNHTTQTKAERR
LLYKLDIIIALYFFMLCWSKSVDLNNYTNAYVSNMKEDLNMKGNDYVYTSTIANVGAIVF
QLPFMYLLPRFPSHIILPVMDLGWTWFTFACYRANSLAELRAYRFILSAFGAAYYPVSQY
ILGCWYAPDEINSRVCLFFCGQQLGSVTSGLLQSRIFKSLNGVHGLAGWRWMFLIDAIAI
SLPTAIIGFFVIPGVPSKCYSLFLTDEEIRIARARNKRNQIKDGVDKSKLAPLWSRKLWK
KVFCTPAFWVLVVFDTCSWNNMTAYSGSYTLWLKSNTKYSIAQVNNLSVIPACLGFAYVI
FCAFGADLFRCKWIFMVFAAIMNTVSCALLIKWDIPSKAKWYAFFTTYFSVAASPCLWSF
INDFLRFDPQVKAITWIAIYSFSQSTYAWIPTLAWPTVESPRFKTGYTVSLIFGAIYGLW
TFVVLFFYKRNEKKHALGNGIILYDSNKGEELPEFVKKNMEERDGYYYLKRSS |
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| References |
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| External Links | |
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| General Reference | - Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
- Stolz, J., Hoja, U., Meier, S., Sauer, N., Schweizer, E. (1999). "Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant." J Biol Chem 274:18741-18746.10373489
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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