Vitamin H transporter (P53241)

Identification
NameVitamin H transporter
Synonyms
  • H(+)/biotin symporter
Gene NameVHT1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transport
Specific FunctionInvolved in uptake of biotin with the concomitant entry of protons
Cellular LocationCell membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00282BiotinShow
YMDB00862hydronShow
GO Classification
Component
Not Available
Function
Not Available
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 7
LocusYGR065C
Gene Sequence>1782 bp ATGACAATTTCGAATAAATCGTGGAGGAGCTACTTCCCACATTTGAGAAAACTACCCGAA GATGATCAGTACTTATACTCAGACGATACTAACTCCAGTATCATAGCTGAAGAGGAGCTA CATCATAGCGTAGATAAGTCCTCGAAGACAGACGTTACGGCAGAAACTACAGCTGTAGAA CCTCATCCTCACAATTTAAGGCATGACTTGCCATATGAAGTGAGAGATGAAGCTGGGCGT AAATGGTGGAAATATTTTGATGAATTCGAGTATCGTGTTAATAAGGAATACAAGAAATCA CGTAAGTGGTACGAGTTTTTGTATCCTAATCATACTACTCAAACCAAGGCTGAAAGACGG CTTCTTTACAAGCTAGACATTATTATTGCTTTATACTTTTTTATGTTATGTTGGTCCAAG TCAGTGGATTTGAATAACTACACTAACGCATATGTTTCCAATATGAAGGAAGATTTAAAC ATGAAAGGTAATGATTACGTTTACACTTCTACTATTGCTAATGTTGGTGCCATTGTCTTC CAATTACCATTTATGTATTTGTTACCAAGATTTCCCTCTCATATTATTTTGCCTGTAATG GACTTGGGCTGGACTTGGTTCACATTTGCATGTTATAGGGCAAACTCACTAGCCGAACTA AGGGCTTACAGATTTATTTTAAGTGCCTTTGGCGCTGCTTACTACCCAGTGTCCCAATAT ATACTAGGTTGTTGGTATGCCCCAGATGAAATTAATTCAAGAGTCTGTTTATTCTTTTGT GGGCAACAATTGGGTTCCGTGACTTCAGGACTTCTGCAAAGTCGCATATTCAAAAGTTTG AACGGCGTCCATGGTCTAGCAGGCTGGAGATGGATGTTTCTGATCGATGCCATTGCAATT TCTCTTCCCACGGCTATTATTGGTTTTTTTGTTATTCCCGGTGTACCATCTAAGTGTTAC TCTTTATTTCTGACTGACGAAGAAATACGAATTGCAAGGGCCAGAAATAAGAGGAACCAA ATCAAAGATGGTGTTGATAAAAGTAAGCTAGCCCCATTATGGAGCAGAAAACTTTGGAAG AAAGTATTTTGTACTCCAGCATTCTGGGTACTTGTTGTTTTTGATACATGTTCGTGGAAT AACATGACTGCGTATAGTGGTTCATATACTTTGTGGTTAAAGTCTAATACAAAGTACTCC ATTGCCCAAGTGAACAACCTGAGTGTTATACCCGCATGTTTAGGATTTGCGTATGTGATT TTTTGTGCCTTTGGTGCCGATTTATTTAGATGTAAGTGGATATTCATGGTTTTTGCTGCT ATAATGAATACCGTTTCTTGTGCCTTACTTATCAAGTGGGATATTCCTTCGAAAGCTAAA TGGTACGCTTTCTTCACCACGTATTTCAGTGTGGCCGCATCGCCTTGTCTATGGTCGTTT ATTAATGACTTCTTAAGGTTTGATCCTCAGGTGAAGGCTATTACATGGATCGCCATTTAT TCCTTCTCTCAATCCACTTACGCCTGGATTCCTACCTTGGCGTGGCCTACCGTGGAGTCA CCACGTTTTAAGACTGGTTACACCGTGAGCTTAATTTTTGGTGCTATTTACGGTTTATGG ACGTTTGTTGTACTTTTTTTTTACAAGAGAAACGAAAAGAAACATGCTCTAGGTAATGGT ATCATCTTGTATGATAGTAATAAGGGTGAAGAGCTTCCAGAATTTGTAAAGAAAAATATG GAGGAAAGAGATGGTTACTACTATTTAAAGCGGTCCTCGTAG
Protein Properties
Pfam Domain Function
Protein Residues593
Protein Molecular Weight69082.10156
Protein Theoretical pI9.07
Signalling Regions
  • None
Transmembrane Regions
  • 122-142
  • 167-187
  • 191-211
  • 225-245
  • 292-312
  • 362-382
  • 409-429
  • 433-453
  • 461-481
  • 493-513
  • 527-547
Protein Sequence>Vitamin H transporter MTISNKSWRSYFPHLRKLPEDDQYLYSDDTNSSIIAEEELHHSVDKSSKTDVTAETTAVE PHPHNLRHDLPYEVRDEAGRKWWKYFDEFEYRVNKEYKKSRKWYEFLYPNHTTQTKAERR LLYKLDIIIALYFFMLCWSKSVDLNNYTNAYVSNMKEDLNMKGNDYVYTSTIANVGAIVF QLPFMYLLPRFPSHIILPVMDLGWTWFTFACYRANSLAELRAYRFILSAFGAAYYPVSQY ILGCWYAPDEINSRVCLFFCGQQLGSVTSGLLQSRIFKSLNGVHGLAGWRWMFLIDAIAI SLPTAIIGFFVIPGVPSKCYSLFLTDEEIRIARARNKRNQIKDGVDKSKLAPLWSRKLWK KVFCTPAFWVLVVFDTCSWNNMTAYSGSYTLWLKSNTKYSIAQVNNLSVIPACLGFAYVI FCAFGADLFRCKWIFMVFAAIMNTVSCALLIKWDIPSKAKWYAFFTTYFSVAASPCLWSF INDFLRFDPQVKAITWIAIYSFSQSTYAWIPTLAWPTVESPRFKTGYTVSLIFGAIYGLW TFVVLFFYKRNEKKHALGNGIILYDSNKGEELPEFVKKNMEERDGYYYLKRSS
References
External Links
ResourceLink
Saccharomyces Genome Database VHT1
Uniprot IDP53241
Uniprot NameVHT1_YEAST
GenBank Gene IDZ72850
Genebank Protein ID1323086
General Reference
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Stolz, J., Hoja, U., Meier, S., Sauer, N., Schweizer, E. (1999). "Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant." J Biol Chem 274:18741-18746.10373489
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258