| Identification |
|---|
| Name | Vitamin B6 transporter TPN1 |
|---|
| Synonyms | - Transport of pyridoxine protein 1
|
|---|
| Gene Name | TPN1 |
|---|
| Enzyme Class | Not Available |
|---|
| Biological Properties |
|---|
| General Function | Involved in nucleobase transmembrane transporter activity |
|---|
| Specific Function | Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine |
|---|
| Cellular Location | Membrane; Multi-pass membrane protein |
|---|
| SMPDB Pathways | Not Available |
|---|
| KEGG Pathways | Not Available |
|---|
| SMPDB Reactions | Not Available |
|---|
| KEGG Reactions | Not Available |
|---|
| Metabolites | | YMDB ID | Name | View |
|---|
| YMDB00037 | Pyridoxine | Show | | YMDB00651 | Cytosine | Show | | YMDB00698 | Guanine | Show | | YMDB00862 | hydron | Show | | YMDB00887 | Adenine | Show |
|
|---|
| GO Classification | | Component |
|---|
| cell part | | membrane | | Function |
|---|
| nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity | | nucleobase transmembrane transporter activity | | transporter activity | | transmembrane transporter activity | | substrate-specific transmembrane transporter activity | | Process |
|---|
| nucleobase, nucleoside, nucleotide and nucleic acid transport | | transmembrane transport | | establishment of localization | | transport |
|
|---|
| Gene Properties |
|---|
| Chromosome Location | chromosome 7 |
|---|
| Locus | YGL186C |
|---|
| Gene Sequence | >1740 bp
ATGAATAGGGACAACATGGACACAACAAAGCGCAAAGAAGATCATACAAAGCATACTACT
GATGTAATAGAATTTTACGAAGAAGGAACCGCAGCTTCTTCTTTAAACATAGCCACAGAA
AAGGCCAACTCAAGTCCGTCCATTTTGAGAAGAATTATCAACAGGGCGGCATGGCTTTCT
AAGAAAGTGGACGCAATGGGAGTAGAGTCTACCGGTATTCAGAGGATATCTCCCTATGAA
CGAGGAACATCAAAGAAACAATTTTTGCATGTCGCGGGGCTATGGTTGAGTGCCACAGGT
GGTTTGTCTTCCATGTCGTCGTTTTTATTAGGCCCTCTGCTTTTCGGTTTAAGCTTTAGA
GAATCCGTAGCCTCCAGTTTAATATCGGTAACAATTGGTTGCTTAATTGCTGCCTATTGC
TCGATCATGGGACCGCAGTCCGGTTGCAGACAGATGGTAACAGCTAGATACCTGTTCGGA
TGGTGGTTTGTTAAATTAGTTGCATTAGCTTCCATTATCGGTGTCATGGGTTGGTCTGTG
GTTAATTCCGTGGTTGGGGGTGAAATGTTAGCTGCTATTTCTAATGATAAAGTACCCCTA
TGGGTAGGGATTGTCATAGTGACCGTATGCTCCTTTTTAGTTGCCATTTTCGGTATCAAA
CAAGTCATTAAAGTGGAAACTTACTTATCCGTACCCGTCCTGACAGCATTTTTACTACTG
TACATTTCATCAAGTGATAAATACAGCTTCGTCAATGCATACGTTTCAAAGGGAAATTTG
GACTCTTCCACCCGAAAGGGCAACTGGATGAGTTTTTTTTCATTATGCTATAGTATTACG
GCTACTTGGGGGTCTATTACAGCAGACTATTATATATTGTTCCCAGAAGATACACCATAT
ATTCAAATTTTTTGCCTAACGTTTTTTGGAACATTTTTGCCTACCTGTTTCGTCGGAATC
TTAGGTCTCTTACTAGCTTCTGTTGCCATGTCGTATAAGCCTTGGTCAGTCGAGTACGAT
TCCCATGGAATGGGTGGTCTACTTTGGGCAGGTTTTCAGCGTTGGAACGGCTTCGGAAAG
TTCTGCGTGGTAGTACTGGTATTCAGTTTGGTATCCAACAACATCATCAATACGTATTCG
GCAGCATTCTCCATCCAACTTTCTAGTGTGTTTTGTGCAAAAATCCCTCGCTGGTTCTGG
TCTATTGTTTGTACTATAATTTGTTTGGTATGCGCATTAATAGGTCGTAATCATTTTAGT
ACTATTTTGGGAAATTTCCTACCAATGATAGGCTACTGGATTAGCATGTACTTTATCTTA
TTATTCGAAGAGAATTTAGTATTCAGAAGGTTTTTCTTACATTTGTACACCAAAGAGTTT
CCTACAGTTACAGGAGAAATAAATGGACCGGAACTTGTTGGATCTTCAAAAGAAGTGGAG
AAAGATGCAGTTACTAATATCCATTTGTTAAAAAGAAAACATAAGGTGACTAAACATCGT
TACAATTGGGACAAATGGGAAGATTATGAGGTTTTAACGCACGGTTATGCAGCAACATTT
GCGTTTATTGTAGGAGTTGCTGGTGTGGTAGTTGGTATGGCGCAAGCCTATTGGATTGGC
CCAATTGCTGCCAAATTTGGTGAATATGGTGGTGATGTCGCAATGTGGTTAAGTATGGCG
TTCTCAGGTGTTGTATACCCTCCTTGTAGATACTTAGAGCTACGTAAATTTGGTCGTTAA
|
|---|
| Protein Properties |
|---|
| Pfam Domain Function | |
|---|
| Protein Residues | 579 |
|---|
| Protein Molecular Weight | 64545.80078 |
|---|
| Protein Theoretical pI | 8.83 |
|---|
| Signalling Regions | |
|---|
| Transmembrane Regions | - 99-119
- 123-143
- 158-178
- 199-219
- 222-242
- 275-295
- 303-323
- 363-383
- 395-415
- 422-442
- 520-540
- 546-566
|
|---|
| Protein Sequence | >Vitamin B6 transporter TPN1
MNRDNMDTTKRKEDHTKHTTDVIEFYEEGTAASSLNIATEKANSSPSILRRIINRAAWLS
KKVDAMGVESTGIQRISPYERGTSKKQFLHVAGLWLSATGGLSSMSSFLLGPLLFGLSFR
ESVASSLISVTIGCLIAAYCSIMGPQSGCRQMVTARYLFGWWFVKLVALASIIGVMGWSV
VNSVVGGEMLAAISNDKVPLWVGIVIVTVCSFLVAIFGIKQVIKVETYLSVPVLTAFLLL
YISSSDKYSFVNAYVSKGNLDSSTRKGNWMSFFSLCYSITATWGSITADYYILFPEDTPY
IQIFCLTFFGTFLPTCFVGILGLLLASVAMSYKPWSVEYDSHGMGGLLWAGFQRWNGFGK
FCVVVLVFSLVSNNIINTYSAAFSIQLSSVFCAKIPRWFWSIVCTIICLVCALIGRNHFS
TILGNFLPMIGYWISMYFILLFEENLVFRRFFLHLYTKEFPTVTGEINGPELVGSSKEVE
KDAVTNIHLLKRKHKVTKHRYNWDKWEDYEVLTHGYAATFAFIVGVAGVVVGMAQAYWIG
PIAAKFGEYGGDVAMWLSMAFSGVVYPPCRYLELRKFGR |
|---|
| References |
|---|
| External Links | |
|---|
| General Reference | - Stolz, J., Vielreicher, M. (2003). "Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae." J Biol Chem 278:18990-18996.12649274
- Coglievina, M., Klima, R., Bertani, I., Delneri, D., Zaccaria, P., Bruschi, C. V. (1997). "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae." Yeast 13:55-64.9046087
- Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
|
|---|