D-serine dehydratase (P53095)

Identification
NameD-serine dehydratase
Synonyms
  • D-serine deaminase
  • DSD
Gene NameDSD1
Enzyme Class
Biological Properties
General FunctionInvolved in D-serine ammonia-lyase activity
Specific FunctionConverts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG Pathways
Glycine, serine and threonine metabolismec00260 Map00260
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00091AmmoniaShow
YMDB00175Pyruvic acidShow
YMDB00284D-SerineShow
GO ClassificationNot Available
Gene Properties
Chromosome Locationchromosome 7
LocusYGL196W
Gene Sequence>YGL196W DSD1 SGDID:S000003164, Chr VII from 129883-131169, Verified ORF, "D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine ATGAGCGATGTTCTATCTCAATATAAAGGGTGCTCAGTCAGAGATTTACCCACACCCAAT TTCGTTATTAATGAAGAAAAATTTGATAAGAATTGTACGACAATGTTGAACAACGTTGAA AAGCTCAGCCAGGAATGTGGCGTACCAATCAAATTTCGTGCACACGTAAAAACGCATAAG ACAGCAAAGGGAACTTTGAAACAATTGGGCCACGGACTTCCATTGGCTAAACGCACTACA AGAGCCATATTAGTATCAACTTTGAAAGAAGCAGAAGAACTTCTTAATTATCAAGATAGA CAATGTTCGGATTATATTGACGATATAACATATAGTTTACCCTGTTGCGTTCCAGAGTTT ATTCCTCTTTTGAGCAATTTGTCAAGAAGGGTGAATAATTTTCAGGTTTTTGTTGATAAC ATTGAACACTTGGAGAATTTAAAGAATTTCGGTAGGCCTGCTTCCGGCAAGAAATGGTCG GTTTTTATCAAGGTTGATATGGGGACTAAGAGGGCAGGTCTTGCTTTCGACTCTCCAGAA TTTTTGAGTCTTTTAAAAAAACTGACTTCCTCAGAAATTAAAGAAGTAATTGAGCCATAT GGGTTTTATGCTCATGCCGGACACAGCTACTCTTCAACCTCGATCAACGACACTCAGAAT CTTTTGATGGAAGAAGTGAAAGCAGTCAATTCTGCCGCTAAAGTTTTGTGCTCTGTGGAT CCTCAGTTTGATCCTTCTAAATTAACACTTTCTGTGGGCGCTACTCCGACTTCCAATTCT TTGAAACTCGATAATAAAAGTACCCTTGTTAAATTCATTACTACTCAATTAGTTAGTACG CTTGAAATCCACTGCGGTAATTACTGCATGTATGACCTGCAACAGGTGGCAACAGGCTGT GTCCAAGATCACGAATTGTCTGGTTTTGTATTAGGAACAGTACTATCATCTTACCCTTCT AGAGGTGAATTGTTGAGTAATACAGGTGTAATGTGTCTAACGCGAGAAGCATCCTCAATA AAAGGGTTTGGAATATGTGCTGATTTGGAACATGTGTTAAAATCCGAGAGTTTCAGTAGG GAATGGTATGTAGCAAGGGTCTCTCAAGAACACGGGATACTGAGGCCAATAAGAAACTGG AACGAAACTACTCCATTAAAATTAGGCAGCAAAATTGCCGTCCTTCCTCAACACGCTTGT ATCACAATGGGACAATTTCCATATTATTTCGTGGTAAACAGCGAAGGCATTGTCAACGAT GTTTGGTTACCTTTTCAGAAATGGTAA
Protein Properties
Pfam Domain Function
Protein Residues428
Protein Molecular Weight47827.39844
Protein Theoretical pI7.64
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>D-serine dehydratase MSDVLSQYKGCSVRDLPTPNFVINEEKFDKNCTTMLNNVEKLSQECGVPIKFRAHVKTHK TAKGTLKQLGHGLPLAKRTTRAILVSTLKEAEELLNYQDRQCSDYIDDITYSLPCCVPEF IPLLSNLSRRVNNFQVFVDNIEHLENLKNFGRPASGKKWSVFIKVDMGTKRAGLAFDSPE FLSLLKKLTSSEIKEVIEPYGFYAHAGHSYSSTSINDTQNLLMEEVKAVNSAAKVLCSVD PQFDPSKLTLSVGATPTSNSLKLDNKSTLVKFITTQLVSTLEIHCGNYCMYDLQQVATGC VQDHELSGFVLGTVLSSYPSRGELLSNTGVMCLTREASSIKGFGICADLEHVLKSESFSR EWYVARVSQEHGILRPIRNWNETTPLKLGSKIAVLPQHACITMGQFPYYFVVNSEGIVND VWLPFQKW
References
External Links
ResourceLink
Saccharomyces Genome Database DSD1
Uniprot IDP53095
Uniprot NameDSD1_YEAST
General Reference
  • Coglievina, M., Klima, R., Bertani, I., Delneri, D., Zaccaria, P., Bruschi, C. V. (1997). "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae." Yeast 13:55-64.9046087
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Kellis, M., Patterson, N., Endrizzi, M., Birren, B., Lander, E. S. (2003). "Sequencing and comparison of yeast species to identify genes and regulatory elements." Nature 423:241-254.12748633
  • Ito, T., Takahashi, K., Naka, T., Hemmi, H., Yoshimura, T. (2007). "Enzymatic assay of D-serine using D-serine dehydratase from Saccharomyces cerevisiae." Anal Biochem 371:167-172.17869212
  • Ito, T., Hemmi, H., Kataoka, K., Mukai, Y., Yoshimura, T. (2008). "A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae." Biochem J 409:399-406.17937657