L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (P50113)

Identification
NameL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms
  • AASD-PPT
Gene NameLYS5
Enzyme Class
Biological Properties
General FunctionInvolved in magnesium ion binding
Specific FunctionCatalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00349Adenosine 3',5'-diphosphateShow
GO Classification
Component
Not Available
Function
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, for other substituted phosphate groups
binding
ion binding
cation binding
metal ion binding
magnesium ion binding
holo-[acyl-carrier-protein] synthase activity
catalytic activity
Process
metabolic process
biosynthetic process
macromolecule biosynthetic process
Gene Properties
Chromosome Locationchromosome 7
LocusYGL154C
Gene Sequence>819 bp ATGGTTAAAACGACTGAAGTAGTAAGCGAAGTTTCAAAGGTGGCAGGTGTAAGACCATGG GCAGGTATATTCGTTGTTGAAATTCAAGAGGATATACTCGCGGATGAGTTTACGTTCGAG GCATTAATGAGAACTTTGCCATTGGCGTCTCAAGCCAGAATCCTCAATAAAAAATCGTTT CACGATAGATGTTCAAATCTATGCAGCCAGCTGCTGCAGTTGTTTGGCTGCTCTATAGTA ACGGGCTTAAATTTTCAAGAGCTGAAATTTGACAAGGGCAGCTTCGGTAAGCCATTCTTA GACAACAATCGTTTTCTTCCATTTAGCATGACCATCGGTGAACAATATGTAGCTATGTTC CTCGTAAAATGTGTAAGTACAGATGAATACCAGGATGTCGGAATTGATATCGCTTCTCCG TGCAATTATGGCGGGAGGGAAGAGTTGGAGCTATTTAAAGAAGTTTTTAGTGAAAGAGAA TTTAACGGTTTACTGAAAGCGTCTGATCCATGCACAATATTTACTTACTTATGGTCCTTG AAGGAGTCGTATACAAAATTTACTGGAACTGGCCTTAACACAGACTTGTCACTAATAGAT TTTGGCGCTATCAGCTTTTTTCCGGCTGAGGGAGCTTCTATGTGCATAACTCTGGATGAA GTTCCATTGATTTTCCATTCTCAATGGTTCAATAACGAAATTGTCACTATCTGTATGCCA AAGTCCATCAGTGATAAAATCAACACGAACAGACCAAAATTATATAATATCAGCTTATCT ACGTTGATTGATTATTTCATCGAAAATGATGGTTTATAA
Protein Properties
Pfam Domain Function
Protein Residues272
Protein Molecular Weight30682.90039
Protein Theoretical pI4.42
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase MVKTTEVVSEVSKVAGVRPWAGIFVVEIQEDILADEFTFEALMRTLPLASQARILNKKSF HDRCSNLCSQLLQLFGCSIVTGLNFQELKFDKGSFGKPFLDNNRFLPFSMTIGEQYVAMF LVKCVSTDEYQDVGIDIASPCNYGGREELELFKEVFSEREFNGLLKASDPCTIFTYLWSL KESYTKFTGTGLNTDLSLIDFGAISFFPAEGASMCITLDEVPLIFHSQWFNNEIVTICMP KSISDKINTNRPKLYNISLSTLIDYFIENDGL
References
External Links
ResourceLink
Saccharomyces Genome Database LYS5
Uniprot IDP50113
Uniprot NameLYS5_YEAST
GenBank Gene IDAY692861
Genebank Protein ID51013173
General Reference
  • Miller, K. G., Bhattacharjee, J. K. (1996). "The LYS5 gene of Saccharomyces cerevisiae." Gene 172:167-168.8654981
  • James, C. M., Indge, K. J., Oliver, S. G. (1995). "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43." Yeast 11:1413-1419.8585324
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ehmann, D. E., Gehring, A. M., Walsh, C. T. (1999). "Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5." Biochemistry 38:6171-6177.10320345
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106