Cys-Gly metallodipeptidase DUG1 (P43616)

Identification
NameCys-Gly metallodipeptidase DUG1
Synonyms
  • Deficient in utilization of glutathione protein 1
  • GSH degradosomal complex subunit DUG1
Gene NameDUG1
Enzyme ClassNot Available
Biological Properties
General Functionglutathione catabolic process
Specific FunctionCatalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.
Cellular LocationNot Available
SMPDB Pathways
Glutathione metabolismPW002395 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glutathione metabolismec00480 Map00480
SMPDB Reactions
L-cysteinylglycine + water → Glycine + L-Cysteine
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00016GlycineShow
YMDB00046L-CysteineShow
YMDB00690L-cysteinylglycineShow
YMDB00890waterShow
GO Classification
Function
metallodipeptidase activity
omega peptidase activity
tripeptidase activity
glutathione catabolic process
metal ion binding
cytoplasm
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1446 bp ATGTCTCACTCACTTACTTCCGTTTTCCAAAAGATTGATTCTTTAAAGCCTCAGTTCTTC AGCAGACTGACTAAGGCTATTCAAATCCCCGCTGTTTCTTCGGATGAATCACTAAGGTCC AAAGTCTTCGATAAGGCCAAGTTTATCTCCGAGCAATTATCACAATCGGGGTTCCATGAC ATTAAAATGGTGGATCTGGGCATTCAACCTCCACCAATTTCTACGCCAAATCTGTCTCTA CCTCCTGTGATTCTGTCTAGGTTCGGCAGCGACCCTTCAAAAAAGACTGTGTTGGTTTAC GGTCACTATGATGTGCAACCTGCTCAATTGGAAGATGGTTGGGATACTGAGCCATTCAAG CTTGTCATTGATGAGGCTAAAGGTATCATGAAAGGAAGGGGTGTCACCGATGACACTGGT CCCTTATTATCTTGGATTAACGTTGTGGACGCCTTCAAAGCCTCCGGACAAGAATTCCCC GTTAACTTAGTTACTTGTTTCGAAGGAATGGAGGAAAGTGGTTCTTTGAAATTGGATGAA TTGATTAAAAAGGAAGCTAATGGTTACTTTAAAGGTGTAGATGCCGTTTGTATTTCCGAT AATTACTGGCTAGGCACTAAGAAGCCTGTTTTGACTTATGGTCTAAGAGGTTGCAACTAC TATCAAACCATCATTGAGGGTCCAAGTGCAGATTTACACTCTGGTATCTTTGGTGGTGTT GTTGCTGAACCAATGATCGATTTAATGCAAGTTCTCGGTTCCCTTGTGGATTCTAAGGGT AAGATCCTGATTGACGGTATTGACGAAATGGTTGCTCCTCTAACCGAAAAGGAGAAGGCT CTATACAAGGATATCGAATTTAGCGTCGAAGAATTGAACGCTGCAACTGGCTCTAAGACA AGTTTGTACGACAAGAAGGAAGACATCTTGATGCACAGATGGAGGTATCCTTCGTTGTCC ATTCATGGTGTGGAAGGCGCCTTTTCCGCTCAAGGTGCAAAGACTGTCATTCCAGCTAAG GTCTTCGGTAAGTTTTCCATTAGAACCGTCCCCGACATGGATTCTGAGAAACTGACCTCT TTGGTCCAGAAGCATTGTGATGCCAAATTCAAGTCCTTGAACTCTCCAAACAAGTGCAGA ACAGAATTGATCCATGATGGTGCTTATTGGGTTTCTGATCCATTCAACGCCCAATTTACT GCTGCTAAAAAGGCCACAAAACTGGTCTATGGTGTCGATCCTGATTTTACCAGGGAAGGT GGTTCCATTCCTATCACTTTGACTTTCCAAGATGCCTTGAACACTAGTGTCTTATTGCTG CCAATGGGTAGAGGCGATGATGGTGCTCATTCAATCAATGAAAAGTTAGATATTTCAAAT TTTGTTGGTGGTATGAAGACGATGGCTGCTTACTTGCAATATTACTCTGAATCGCCAGAA AACTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues481
Protein Molecular Weight52870.91
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Cys-Gly metallodipeptidase DUG1 MSHSLTSVFQKIDSLKPQFFSRLTKAIQIPAVSSDESLRSKVFDKAKFISEQLSQSGFHD IKMVDLGIQPPPISTPNLSLPPVILSRFGSDPSKKTVLVYGHYDVQPAQLEDGWDTEPFK LVIDEAKGIMKGRGVTDDTGPLLSWINVVDAFKASGQEFPVNLVTCFEGMEESGSLKLDE LIKKEANGYFKGVDAVCISDNYWLGTKKPVLTYGLRGCNYYQTIIEGPSADLHSGIFGGV VAEPMIDLMQVLGSLVDSKGKILIDGIDEMVAPLTEKEKALYKDIEFSVEELNAATGSKT SLYDKKEDILMHRWRYPSLSIHGVEGAFSAQGAKTVIPAKVFGKFSIRTVPDMDSEKLTS LVQKHCDAKFKSLNSPNKCRTELIHDGAYWVSDPFNAQFTAAKKATKLVYGVDPDFTREG GSIPITLTFQDALNTSVLLLPMGRGDDGAHSINEKLDISNFVGGMKTMAAYLQYYSESPE N
References
External Links
ResourceLink
Saccharomyces Genome Database DUG1
Uniprot IDP43616
Uniprot NameDUG1
PDB ID
4G1P
General ReferenceNot Available