Dolichyl-phosphate-mannose--protein mannosyltransferase 6 (P42934)

Identification
NameDolichyl-phosphate-mannose--protein mannosyltransferase 6
SynonymsNot Available
Gene NamePMT6
Enzyme Class
Biological Properties
General FunctionInvolved in mannosyltransferase activity
Specific FunctionTransfers mannose from Dol-P-mannose to Ser or Thr residues on proteins
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG Pathways
O-Mannosyl glycan biosynthesisec00514 Map00514
SMPDB ReactionsNot Available
KEGG Reactions
dolichyl D-mannosyl phosphate → dolichyl phosphate + hydron + mannan
Metabolites
YMDB IDNameView
YMDB00937dolichyl D-mannosyl phosphateShow
GO Classification
Component
cell part
membrane
Function
transferase activity, transferring hexosyl groups
mannosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
protein amino acid O-linked glycosylation
Gene Properties
Chromosome Locationchromosome 7
LocusYGR199W
Gene Sequence>2280 bp ATGAGTAAAGCCAAGGGAACGGGATTTTCATCAATTGATACTGAAGATGAAAACTTACGC GAACGTTATGTTAATCAACCAAAAGCTAATGCCTCCGATATTCAAGATGAACAATTAGAT TGCTTTGAGCAACTAGAAGAAAAACATAGGACAAAAAAAAATGAAGAATACACTGCGTTG AAAATTTTAAGGGATGTCATAGGTCCCCTTTTATTAACTATAACTTCGTTTTATCTAAGA TTCCAACATATAGATCAGAACAATTATGTTGTCTGGGATGAGGCTCATTTTGGGAAATTC GGATCATACTACATCAAACATGAGTACTACCACGATGTCCACCCTCCACTTGGTAAAATG CTTATTGCATTGAGCGAATGGATGGCAGGATTTGACGGTCAATTTGACTTTTCCTCTAAT AATGCATATCCGGAAAACGTAAACTTTAAACTAATGAGACAATTTAATGCCACATTTGGA GCTCTATGTACACCAGTAGCTTTCTTTACAGCCAAATGGATGGGGTTCAATTATTTTACT GTTTATTTGATTGCTACGATGGTAACGTTGGAACATTCATATATTGTCCTCTCAAAATTC ATATTGCTAGATTCAATGCTGCTTTTTTTCTCGATGACGACTTTTGCCTGTATGATAAAG TTGTATACGTTGAGAAAGCAACAAATGACGAAAAAATGGTCGTTATGGATGTTATTAACT GGTTTATCTATTGGTTGCGTTTGTTCTGTGAAATGGGTTGGTCTTTTTATCACAGTTGTA GTCGGCCTCTACACATGTATAGAACTATTTTTGCTCTATTGTGATAAAGAATTGCCTAGA ATAAAATATTACAAACATTGGCTTATCAGAATCATTAATCTGATAGTAATTCCTTTTCTT ATCTATCTCTATTGCTTCAAAATTCACTTTGTGTTGTTGTACAAATCTGGCACGGGGGAT TCTACTACAAATACGTTATTTCAGATAAACTTGGAGGGAACTCAGATTGAGGCGGGTCCT CGTGATGTAGCATTTGGGTCAGAGTTAACCATAAGGTCGCATGGTTTAAGCCCGAATCTG CTGCATTCACATATTCAAGTATACCCAGAAGGCTCTGGACAGCGCCAAATCACTGGATAT GGATTCGCAGACTCTAATAATGTTTGGAAGTTTGAATTTTCTAGGTCTTCTGGATTGGAA CTAGATCAGAACGGGACTTTGAATGGCAAAATAATCCCAATAACGGATGGTGTGGAAGTT CGTCTCAGCCATAAAAATACAGGATCGAATCTTCACTCGCATGATGTACCTTCTCACGTC TCTAGAGGAAATTATGAGGTTTCAGGCTATGGGTCACAAAGTGTTGGCGATGAAAAGGAT GATTGGATAGTGGAGATTGTGAAACAAATGGATTCACCAAATCCCGTCTATTCTAATGAG AATTCAACTATTTTACATCCAGTTTCTACTTTCTTCAGGTTGAGACACAAAGTTTTAGGT TGTTACTTGGCTTCTACTGGATTGACGTATCCAGCTTGGGGATTTAAACAAGCTGAAATC GTCTGCAAAGACTCCTGGAGTCGTAGGGACAAATCGACCTGGTGGAATGTAGAAGATCAC TGGAACCACAATTTAGAAACCGCAGAAGATTACGTTCCACCAAAATCCAATTTTTGGACC GATTTTATTCTAACTAATTTTGCCATGGCCTCCTCTAATAACGCGTTAGTGCCTGATGAG GATAAATATGATAGTTTATCGTCTGATGCATGGGAATGGCCAACCTTGCATAAAGGGCTA AGAATGTGTTCATGGGCGGGATATATCACTCGATATTACTTGATGGGATCTCCCTTCAAT ACATGGATTTCTACTGTCTCCTTAATCATCTTCCCATTTATTATTCTTTTTATATTATAT CGTTGGAGGAGACAAACGCTTTATCTCTCAGACGATCAAATCTGGCAAATAACGATACAG GGTATTTTTCCTTTCATTTCCTGGATGACACATTATCTGCCTTTTGCAATGATGGGGAGA GTGACGTATGTACATCACTACGTTCCCGCTTTATATTTTGCAATGCTTGTTTTCGGATTT GTGCTTGATTTCACTTTGACAAGAGTCCATTGGATGGTCAAATATCCCATCTATTTGTCA TTGTTTGGCGGATGTATATACATTTATAATTTATTTGCTCCAATATGTCAGGGTATGCAT GGTGATAAAGCGGAATACTTACCTTTGCAGTGGTTATCTACTTGGGATATCGCACCTTAG
Protein Properties
Pfam Domain Function
Protein Residues759
Protein Molecular Weight88025.39844
Protein Theoretical pI6.84
Signalling Regions
  • None
Transmembrane Regions
  • 59-79
  • 165-185
  • 195-215
  • 252-272
  • 294-314
  • 619-639
  • 657-677
  • 687-707
  • 716-736
Protein Sequence>Dolichyl-phosphate-mannose--protein mannosyltransferase 6 MSKAKGTGFSSIDTEDENLRERYVNQPKANASDIQDEQLDCFEQLEEKHRTKKNEEYTAL KILRDVIGPLLLTITSFYLRFQHIDQNNYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKM LIALSEWMAGFDGQFDFSSNNAYPENVNFKLMRQFNATFGALCTPVAFFTAKWMGFNYFT VYLIATMVTLEHSYIVLSKFILLDSMLLFFSMTTFACMIKLYTLRKQQMTKKWSLWMLLT GLSIGCVCSVKWVGLFITVVVGLYTCIELFLLYCDKELPRIKYYKHWLIRIINLIVIPFL IYLYCFKIHFVLLYKSGTGDSTTNTLFQINLEGTQIEAGPRDVAFGSELTIRSHGLSPNL LHSHIQVYPEGSGQRQITGYGFADSNNVWKFEFSRSSGLELDQNGTLNGKIIPITDGVEV RLSHKNTGSNLHSHDVPSHVSRGNYEVSGYGSQSVGDEKDDWIVEIVKQMDSPNPVYSNE NSTILHPVSTFFRLRHKVLGCYLASTGLTYPAWGFKQAEIVCKDSWSRRDKSTWWNVEDH WNHNLETAEDYVPPKSNFWTDFILTNFAMASSNNALVPDEDKYDSLSSDAWEWPTLHKGL RMCSWAGYITRYYLMGSPFNTWISTVSLIIFPFIILFILYRWRRQTLYLSDDQIWQITIQ GIFPFISWMTHYLPFAMMGRVTYVHHYVPALYFAMLVFGFVLDFTLTRVHWMVKYPIYLS LFGGCIYIYNLFAPICQGMHGDKAEYLPLQWLSTWDIAP
References
External Links
ResourceLink
Saccharomyces Genome Database PMT6
Uniprot IDP42934
Uniprot NamePMT6_YEAST
GenBank Gene IDZ49133
Genebank Protein ID790490
General Reference
  • Guerreiro, P., Barreiros, T., Soares, H., Cyrne, L., Maia e Silva, A., Rodrigues-Pousada, C. (1996). "Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs." Yeast 12:273-280.8904340
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956