| Identification |
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| Name | Valine amino-acid permease |
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| Synonyms | - Branched-chain amino-acid permease 3
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| Gene Name | BAP3 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transport |
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| Specific Function | Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan |
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| Cellular Location | Membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00038 | L-Isoleucine | Show | | YMDB00046 | L-Cysteine | Show | | YMDB00126 | L-Tryptophan | Show | | YMDB00152 | L-Valine | Show | | YMDB00154 | L-Alanine | Show | | YMDB00214 | L-Threonine | Show | | YMDB00304 | L-Phenylalanine | Show | | YMDB00318 | L-Methionine | Show | | YMDB00364 | L-Tyrosine | Show | | YMDB00387 | L-Leucine | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| cell part | | membrane | | membrane part | | intrinsic to membrane | | integral to membrane | | Function |
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| amine transmembrane transporter activity | | amino acid transmembrane transporter activity | | transporter activity | | transmembrane transporter activity | | active transmembrane transporter activity | | Process |
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| amine transport | | amino acid transport | | transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 4 |
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| Locus | YDR046C |
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| Gene Sequence | >1815 bp
ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACA
GACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATT
AAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGA
AGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATG
AAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTA
GGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGC
CCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAA
GCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAAT
TCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGG
TTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGAC
ACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTT
TTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATG
GTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGC
TATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACT
CGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAA
TTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCG
AAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTC
AATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCA
CCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCT
GTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTA
ATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAG
GGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCC
TGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAA
CTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTC
CAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATAC
TATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCA
ATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCG
CTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAAC
CCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGG
CAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTAC
AAATTTTGGTGTTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 604 |
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| Protein Molecular Weight | 67364.39844 |
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| Protein Theoretical pI | 8.28 |
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| Signalling Regions | |
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| Transmembrane Regions | - 96-116
- 120-140
- 170-190
- 207-227
- 239-259
- 285-305
- 324-344
- 378-398
- 424-444
- 450-470
- 503-523
- 532-552
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| Protein Sequence | >Valine amino-acid permease
MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFR
RAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAG
PGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQW
LTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILM
VAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIE
LFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHAS
PYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDRE
GRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKV
QGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAP
LWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVY
KFWC |
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| References |
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| External Links | |
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| General Reference | - Mai, B., Lipp, M. (1994). "Cloning and chromosomal organization of a gene encoding a putative amino-acid permease from Saccharomyces cerevisiae." Gene 143:129-133.8200527
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- During-Olsen, L., Regenberg, B., Gjermansen, C., Kielland-Brandt, M. C., Hansen, J. (1999). "Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases." Curr Genet 35:609-617.10467005
- Regenberg, B., During-Olsen, L., Kielland-Brandt, M. C., Holmberg, S. (1999). "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae." Curr Genet 36:317-328.10654085
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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