Low-affinity Fe(2+) transport protein (P40988)

Identification
NameLow-affinity Fe(2+) transport protein
Synonyms
  • Low-affinity Fe(II) transport protein
Gene NameFET4
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transport
Specific FunctionRequired for Fe(2+) ion low affinity uptake
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00379Iron(2+)Show
GO Classification
Component
Not Available
Function
Not Available
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 13
LocusYMR319C
Gene Sequence>1659 bp ATGGGTAAAATTGCAGAGTTTCTCGGGAATCCAGGTGCTAGGCCTGACGTTCATCATAGA GCACCTACTGTTGACTGCAAACAGTACGAAGAATTCGGTGATTCTAACGATTACAAAAAT GATGATGTGGTCAGAGTAGTCAGCCATAGCGATGAGAGTACTGATGACGAACTTTGTAAT GTGAATTTAACAGAAACAGGGGCAATCTTCACGAGTAAAGGTTTTACCGGGTTAAGCAAA GGTTTCACAGATAAGACCCTGGATTTCCTGGTACGAGTGGCCGGTTCGCAGGCGGTTTTT TTTATTGTTTGGATCATCCTCATAATTTGGGTGGTTATTGGTATTGTTTATAACGCACCT TTCAATTGGCAAGTTGTTATGCAGGACGGACAGTCCATTCAAAGTTATGTTTGGGACACA CTGTTGATGAGACAACAGTTGATGAGTACGCATGAACAAATTTTGATCTGCGGTAGATTG AAGTCGAGATTGGCTTCCTTCAAAAACTATCTAACAAGAAGCACCCCAGAGGAAGAAAAA GCAGACTGCACAGTTGAAGCTAATGAAGTCAGCTCTGTTGAAAATCATATAGACCCATCT GCCATTAACGGAGAACTGCCTGTGGAAAATTGGTACGACCGTTTATCTAATGTAGCAAGT AGGTATATGGGTTCAATTGCAGCAATGGTGATATTTTGGATAGGTATTTTCGTTTGGATT GGTTGCGGTGCTATCCCAAAAGATGCGGGCAACACTCCACCTTACACCGGAGAAACTACA GGTAGTAATCCAAGATTGAAAAAGTTCAGTGACGCTTGGCAGATGTATATTAACACTGCA GTTGCAATTTCCCTTCTAATTTGCACTACTTTCTTACAAAATATAAGGGCCAGACATGAT TATTTCACGGGGAGGTTTTTAGTTGATATCTTTGATATGGACGAGAAAATCGACTATCGT ATAAGAAAGCATTTTAACGATTTTGAAACACCTCACCCAGTTGTTACCATTGAGTCTAAA AAAAGGTCGACAGGGAGAAAGATGATTGATTGGTATGCTGATATTATTGGTACTGGTATT GGTGTCCTGATCGGTGTGGCAGTGTTCGCTACATGGATTGGTATTGGTTCGCCAATGAAG TGGGATGATAATTGGTGGTTGATTATCGGTACATACACAGGTTTAATTGGGTTTTTGGAC GGTTTCGTTTTGAGAGAAGTGTACTTCCGAATCGTTCAACATGAAGAGAAAAATTATTCT GATGTGGCTAAAGAAGACCTTGAATTATTCCAAGAATTAGGTATTGAATGTCCCGAAGAA CTTAGTGGTAAAGCTCCTGAAATTAACATTATTGGTTACAGAACATCCCAATATATTAAT AGGATCTGCTCAACTCCATGGAGTGTTCTTGTATCCGTCATCATCATCATTGGTTTAATT TGTATTGCTTCCGGTTTGCGTTGGAGTACAACAGGTCAATTGATTGCTAACACGCCAACT ATGATTATCGAAGAATTTTTCTTGCTAGTTTTGTTGCAAGCACATAATTGGGCCGATCGT CAAAGAAGAGTGGAGGTTACCGCTTTGTACGCACGTAGGCGCATACTTCTATCATACGTA GAAAAGCGTTTCCCAGAGGTTATGATGTTGGAAAAATAG
Protein Properties
Pfam Domain Function
Protein Residues552
Protein Molecular Weight62791.5
Protein Theoretical pI5.16
Signalling Regions
  • None
Transmembrane Regions
  • 98-118
  • 226-246
  • 272-292
  • 355-375
  • 384-404
  • 466-486
  • 494-514
Protein Sequence>Low-affinity Fe(2+) transport protein MGKIAEFLGNPGARPDVHHRAPTVDCKQYEEFGDSNDYKNDDVVRVVSHSDESTDDELCN VNLTETGAIFTSKGFTGLSKGFTDKTLDFLVRVAGSQAVFFIVWIILIIWVVIGIVYNAP FNWQVVMQDGQSIQSYVWDTLLMRQQLMSTHEQILICGRLKSRLASFKNYLTRSTPEEEK ADCTVEANEVSSVENHIDPSAINGELPVENWYDRLSNVASRYMGSIAAMVIFWIGIFVWI GCGAIPKDAGNTPPYTGETTGSNPRLKKFSDAWQMYINTAVAVSLLICTTFLQNIRARHD YFTGRFLVDIFDMDEKIDYRIRKHFNDFETPHPVVTIESKKRSTGRKMIDWYADIIGTGI GVLIGVAVFATWIGIGSPMKWDDNWWLIIGTYTGLIGFLDGFVLREVYFRIVQHEEKNYS DVAKEDLELFQELGIECPEEFSGKAPEINTIGYRTSQYINRICSTPWSVLVSVIIIIGLI CIASGLRWSTTGQLIANTPTMIIEEFFLLVLLQAHNWADRQRRVEVTALYARRRILLSYV EKRFPEVMMLEK
References
External Links
ResourceLink
Saccharomyces Genome Database FET4
Uniprot IDP40988
Uniprot NameFET4_YEAST
GenBank Gene IDL34837
Genebank Protein ID567911
General Reference
  • Dix, D. R., Bridgham, J. T., Broderius, M. A., Byersdorfer, C. A., Eide, D. J. (1994). "The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae." J Biol Chem 269:26092-26099.7929320
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258