Tyrosine-protein phosphatase 3 (P40048)

Identification
NameTyrosine-protein phosphatase 3
Synonyms
  • Protein-tyrosine phosphatase 3
  • PTPase 3
Gene NamePTP3
Enzyme ClassNot Available
Biological Properties
General Functionregulation of sporulation
Specific FunctionMajor phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
protein tyrosine phosphatase activity
protein dephosphorylation
inactivation of MAPK activity involved in osmosensory signaling pathway
regulation of sporulation
inactivation of MAPK activity involved in conjugation with cellular fusion
nucleus
cytoplasm
regulation of protein localization
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2787 bp ATGAAGGACAGTGTAGACTGCCCAAGCATTCTACCCACCGACCGCACTTCAGTGCTTTCC GAGACTAGCACTTTGGTCGGATCGAGTTCGCATGTATATTCGAGGCATGCTCCTATGAAC AGTTATCATAACAGCATGAACAGCAACATATACCACAGCCCCAAAGCCAGTAGCCCTTTG GTGAGCTATAAGACATCTTCGCCGGTGTTATTGAAGAGGGCGACCGCTCCTGTCCTGCCA AGCTTCAAGCCCAAGGAACAGCGATATAATAAGCCGCAGGGTTGTTCGCTAATTACTGCT GTAGAACTGGGCAAGATTATTGAAACCTTACCAGATGAAAAGGTGCTCTTACTTGATGTT AGGCCGTTTACCGAACATGCCAAATCCATTATCACAAACTCCATTCATGTATGTTTGCCT TCCACGCTGCTGAGGAGGAAAAATTTCACCTTTTCCAAACTCTTGGACAACTTAACTCCT AGCGAGCAAAGCGTGTTGAAATCTAAACTGGCCATCGATAACCTTCGGATTATCATTTAT GATAGCACCGCAAATCAAACGGAAAGTTCTGTTTCTTTACCTTGTTATGGAATAGCGTCC AAGCTAATAGAGTTTGATACTAATGTTAAAAAAACCGTGTCTATACTAATGTGTGGTTTT CCTCAATTCAAAATTCTATTTCCAGACCATATAAACACCAACACATTTAACTCAGATTGC ATTAGTTCGGCTGAACCTAAAAGCCCCAAGACAAACCTTATGAACAGTCTACACAACACA GCGCCGCATATGACGGCGACAACACCACTATCGTCTCCGCAAATGAACCTTAAGTTGAAA GTTCCTGACGATAGTAGGTCAGATCATTCAAACTTTTCCAGTTCTCCCTCTCCGCGTAAC GTCCTATCAGATTCTCCCATGTCTTCTTCTTCCCCCATATCTGCCTTATTTAAGTTCCAG CTGCCTGCACCACAAACAAACATAAACCAAATGTTCAAATTTTCGCAAAATGAAGAAATA ATGGGTTTAGAGACGTATTTGAGTGCAGTCAACATCAAAGAAGAACATGAAAGATGGTAT AATAACGATTCTGCCAAAAAATCTTTACAAAACTTCCAATTCCCAAAGAACCAAAATTCT CTAGAAAAGGACACTAATAAAGACAAACTAGGGTTTCAGATCAGATACGAAAACCTGAGC AAAAATTACGAAAAGGAGGTCATTGACTCCGTTATACCTGAATGGTTCCAGCATCTGATG TCAATACCCAAGATCGAGTTGGTTTCTCAGTTTCAAAAATTAGATTTTTTGGAAAAAAGG CGCTTGAACCATTCTGTCTCTTTCAGGAAGAAGGAAAACTCGTTTATACTTGAAAAGCCA TCATCATATCCTGAACAGTTAACATCAACTTCTTCTTCAACAATCATGCCTCCAAAATTT CCTGACGTGAACAAAGTACAAAAGAGGTCGCATTCTCAGCCAATCTTCACTCAATACAGT AAATATAAATCGATGCTCAGCCTTGAATCAGATTCCGATTCGGAGTCAGATGACGTTATA ATATCATCAGGCGTTGAATTAGGAGCCAAGAACAGGTACAAGGATATTTTTCCCTACGAG CATTCGAGAGTGATTCTAAAAAAAGGTTTGCAATCATCAAAAGGTATCAAGCATTCACAT TCTACTTCCGATGGTGGCATCCTCGACAATTATATCAACGCAAACTATTTGTCTCTGCCA AGGTTTTCTGTAGAGCAAAATTCGTCATTTCAAACAACTACAACCACAACAAGAAGAGTG CGCTATATAGCGACGCAAGCTCCAATGCCCTCCACTGTACATGACTTTTATACATGCATA TTGAATAATGGCGTTCCGTTGGTTCTCTCATTGACAAATGATTTCGAAAATGGCATTGAG AAATGTTATCGATATTGGCAAGAAGGTAATTATAACGGTATTCACGTTAAATTGTTAGAA AAAAAAATATTAAAGATGCCTAGCACTACTAGCATGAGGAAAAATACTATGGGAACACAA AATAGTAGTTTATATTCAGCTGGTGTTCAGGGAAATAGTAGTAACTATAGTACTGATAAT GATAATGATAATGACAACAATAATAATAACAATAACAATAGTAATATTGCTGTTACTGCT GCTGCTTGTGATGATGATGATGATGATGATGATGACGCAATTCTCATAAGAAAAATTCTG CTAACATATCATGATCAAGAGAAACCTTATGAATTGTTACAGATTCAGGTGAAAAATTGG CCTGATTTGGGCACTTTACTCAATCCTATCTCAATCTTACAAGCAATCAATGTCAAGAAT CACATAATAGATACACTATTTGCCAGAAATTACTATCAAAACGACCAACTTCCTACCATT TTGGTTCATTGTTCCGCAGGTTGTGGAAGGACTGGTACTTTGTGTACCATTGATTCCATT CTATCCAATTTCGAAATGTTTGAAATGTTGCAGAAAGAGTTTGTTAAATTAAAATACCCG GCAAAGTTATTCGATCCAATTTCATGGACAATTAATATTTTTAGAAAGCAACGAATATCC ATGGTCCAGAACATTAATCAATTTATTTTCATTTATGACTGCTTGCTATTTTACTTTAGA TTACGTCTTGATGACATAACAGAGAGAACGGATGGTGATGGAAGTAACAAGGACAATATA TCATTAAGTGCATTAATTGAACAAATCGAAAAATTAGAGATCTTGCAGACATTCGTGGAT GATAAGTTGAAAGAATTGCCACAATAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues928
Protein Molecular Weight105223.015
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Tyrosine-protein phosphatase 3 MKDSVDCPSILPTDRTSVLSETSTLVGSSSHVYSRHAPMNSYHNSMNSNIYHSPKASSPL VSYKTSSPVLLKRATAPVLPSFKPKEQRYNKPQGCSLITAVELGKIIETLPDEKVLLLDV RPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQSVLKSKLAIDNLRIIIY DSTANQTESSVSLPCYGIASKLIEFDTNVKKTVSILMCGFPQFKILFPDHINTNTFNSDC ISSAEPKSPKTNLMNSLHNTAPHMTATTPLSSPQMNLKLKVPDDSRSDHSNFSSSPSPRN VLSDSPMSSSSPISALFKFQLPAPQTNINQMFKFSQNEEIMGLETYLSAVNIKEEHERWY NNDSAKKSLQNFQFPKNQNSLEKDTNKDKLGFQIRYENLSKNYEKEVIDSVIPEWFQHLM SIPKIELVSQFQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSSTIMPPKF PDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRYKDIFPYE HSRVILKKGLQSSKGIKHSHSTSDGGILDNYINANYLSLPRFSVEQNSSFQTTTTTTRRV RYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLE KKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNNSNIAVTA AACDDDDDDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKN HIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYP AKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLDDITERTDGDGSNKDNI SLSALIEQIEKLEILQTFVDDKLKELPQ
References
External Links
ResourceLink
Saccharomyces Genome Database PTP3
Uniprot IDP40048
Uniprot NamePTP3
General ReferenceNot Available