Nuclear distribution protein PAC1 (P39946)
Identification | |||||||||||||||||||
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Name | Nuclear distribution protein PAC1 | ||||||||||||||||||
Synonyms |
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Gene Name | PAC1 | ||||||||||||||||||
Enzyme Class | Not Available | ||||||||||||||||||
Biological Properties | |||||||||||||||||||
General Function | positive regulation of microtubule plus-end binding | ||||||||||||||||||
Specific Function | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8. | ||||||||||||||||||
Cellular Location | Not Available | ||||||||||||||||||
SMPDB Pathways |
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KEGG Pathways |
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SMPDB Reactions |
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KEGG Reactions | Not Available | ||||||||||||||||||
Metabolites |
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GO Classification |
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Gene Properties | |||||||||||||||||||
Chromosome Location | Not Available | ||||||||||||||||||
Locus | |||||||||||||||||||
Gene Sequence | >1485 bp ATGACTAACTGGCAGCAACAGCTTCCTTTAACAGATACACAGAAAAATGAACTCGATAAA AGTGTCCTCCGATATTTGAATTGGAATTACAAACAAACTGTACGACATGAGCATGCTCAA GATTACGAAAGTGTTCGACATGCAATTGTAACTCTATCAGGTTTTCTGTTGCAAGAATCA GTGGACCGGCAAGAATTCATCAGTAACAATGACACCAGTAACGAAAGTATGGTAGACATT GATGAATTACTGCTACCGAAGAAGTGGAACTCAATTGTTAGACTACAAAAAAAAATCATT GAATTGGAGCAGAATACAGAGACCCTTGTATCTCAGATTAAAGATTTGAACACTCAAGTG TCAGAACTAGCACAATTCAAACCTACCACCAGTAACGGCACCAGCGCACATAATGTTTTG AAATGGATACCGAGAAATCTACCAAGCTGTTTAATTAATGTTGAATCATCTGTCACTTCC GTCAAACTACATCCCAATTTGCCTATAGTGTTTGTGGCCACAGATCATGGCAAATTATAC GCATTTGATTTATTTAACTACACCATCCCTCTGGCATCCTTGCAAAGTCATACCAAGGCA ATTACCTCCATGGATGTTTTATTTACCAATTATACGAACTCCAGCAAGAAGAACTATTTG GTGATCGTTACCGCGTCTAAAGATTTGCAGATTCATGTTTTCAAGTGGGTCTCCGAGGAA TGCAAGTTCCAACAAATTAGGTCTTTATTGGGCCATGAGCATATTGTCTCTGCGGTAAAA ATCTGGCAGAAAAATAATGATGTCCATATAGCGTCCTGTTCCAGAGATCAAACTGTTAAA ATTTGGGACTTCCACAATGGTTGGTCGTTGAAAACATTTCAGCCTCATTCCCAATGGGTT CGTTCCATAGACGTTCTAGGCGATTACATCATCTCTGGTTCACATGACACTACATTAAGG TTAACACATTGGCCATCAGGTAATGGTCTTAGTGTTGGCACGGGTCATGAATTTCCCATA GAGAAAGTTAAATTTATTCATTTCATCGAAGACTCTCCGGAGATAAGGTTTAGAACACCA TCAACGGATCGATATAAGAATTGGGGGATGCAATATTGTGTCTCAGCGTCAAGAGATAGA ACGATAAAAATCTGGGAGATACCTCTACCTACGTTAATGGCCCATAGAGCACCCATACCG AATCCTACAGATTCAAATTTCAGATGTGTTCTTACGTTGAAGGGGCATCTTTCGTGGGTT AGAGATATTAGTATTCGAGGCCAATACTTGTTTTCTTGTGCTGATGATAAATCTGTCAGA TGTTGGGATCTGAACACGGGGCAGTGCTTACACGTTTGGGAAAAGTTGCATACAGGATTT GTCAACTGTTTAGACCTGGATGTGGATTTCGATTCTAACGTTACCCCAAGGCAAATGATG GTCACTGGTGGATTGGATTGCAAGTCTAACGTTTTCATGAGATAA | ||||||||||||||||||
Protein Properties | |||||||||||||||||||
Pfam Domain Function | Not Available | ||||||||||||||||||
Protein Residues | 494 | ||||||||||||||||||
Protein Molecular Weight | 56900.345 | ||||||||||||||||||
Protein Theoretical pI | Not Available | ||||||||||||||||||
Signalling Regions | Not Available | ||||||||||||||||||
Transmembrane Regions | Not Available | ||||||||||||||||||
Protein Sequence | >Nuclear distribution protein PAC1 MTNWQQQLPLTDTQKNELDKSVLRYLNWNYKQTVRHEHAQDYESVRHAIVTLSGFLLQES VDRQEFISNNDTSNESMVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQV SELAQFKPTTSNGTSAHNVLKWIPRNLPSCLINVESSVTSVKLHPNLPIVFVATDHGKLY AFDLFNYTIPLASLQSHTKAITSMDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEE CKFQQIRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWV RSIDVLGDYIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTP STDRYKNWGMQYCVSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWV RDISIRGQYLFSCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMM VTGGLDCKSNVFMR | ||||||||||||||||||
References | |||||||||||||||||||
External Links |
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General Reference | Not Available |