E3 ubiquitin-protein ligase RSP5 (P39940)
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| Name | E3 ubiquitin-protein ligase RSP5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| Gene Name | RSP5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Enzyme Class | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
| General Function | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | ||||||||||||||||||||||||||||||||||||||||||||||||
| Specific Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other cell surface proteins like GAP1, FUR4, MAL61, PMA1 and STE2. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription, pressure-induced differential regulation of the two tryptophan permeases TAT1 and TAT2 and sorting efficiency into multivesicular bodies. Also acts on RBP1. Plays a role in tolerance to o-dinitrobenzene. Involved in actin cytoskeleton organization and dynamics. Ubiquitinates the LAS17-binding proteins LSB1 and PIN3/LSB2 without directing them for degradation and affects LAS17 levels in a SLA1-dependent and LSB1/2-independent manner. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Location | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Reactions | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Reactions | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
| Chromosome Location | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Locus | |||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Sequence | >2430 bp ATGCCTTCATCCATATCCGTCAAGTTAGTGGCTGCAGAGTCATTATATAAGAGGGACGTA TTCCGTTCCCCGGATCCGTTTGCTGTTCTGACTATTGATGGTTACCAAACCAAATCTACA TCCGCAGCGAAGAAAACGTTAAATCCCTACTGGAATGAGACTTTCAAATTCGACGATATC AATGAAAATTCTATTTTAACCATCCAAGTCTTTGATCAAAAGAAATTTAAAAAGAAGGAT CAAGGGTTTCTTGGCGTGGTTAACGTCCGCGTGGGTGATGTTTTGGGCCATTTGGATGAA GATACTGCTACATCGAGTGGTAGACCTCGCGAAGAAACTATTACTCGTGATTTAAAAAAA TCTAATGACGGAATGGCCGTCAGCGGTAGGTTGATTGTTGTTTTATCAAAACTACCTTCG TCAAGTCCGCATTCACAAGCTCCTTCTGGCCATACTGCATCTTCTAGTACGAATACAAGT TCAACTACTCGAACAAATGGTCATTCTACTTCCTCCACCCGTAATCATTCAACGTCTCAT CCTTCCAGAGGCACCGCGCAAGCAGTAGAATCAACTCTTCAAAGCGGTACAACAGCTGCT ACTAATACGGCAACAACCAGTCACCGTTCCACCAATTCCACATCCAGTGCTACCAGACAA TACTCTTCGTTTGAAGACCAGTATGGTCGTTTACCCCCTGGTTGGGAGAGAAGGACCGAT AACTTTGGTCGTACATATTACGTCGATCATAACACAAGGACTACCACTTGGAAACGTCCA ACGCTCGATCAAACAGAAGCCGAACGTGGCAACCAATTAAATGCAAATACTGAGTTAGAG AGAAGGCAGCATAGGGGAAGAACTTTACCTGGTGGATCATCAGATAATTCCTCTGTAACA GTTCAAGTGGGAGGTGGTTCCAATATACCTCCTGTTAATGGTGCAGCAGCAGCAGCGTTT GCAGCTACAGGTGGTACCACATCTGGTTTAGGCGAATTACCTTCAGGCTGGGAGCAGCGA TTTACTCCAGAAGGAAGAGCTTATTTCGTTGACCATAATACTAGAACAACCACTTGGGTG GATCCAAGGAGACAACAGTATATACGTACTTATGGCCCTACAAATACCACCATTCAGCAA CAACCGGTCTCCCAATTAGGTCCTTTGCCTTCTGGATGGGAAATGAGATTGACCAATACG GCACGTGTATATTTCGTTGACCACAATACAAAAACAACGACCTGGGATGACCCAAGACTT CCATCATCGCTAGACCAAAATGTTCCACAATACAAGCGTGACTTCAGACGTAAGGTTATT TATTTCAGGTCCCAGCCCGCTCTTAGAATATTGCCGGGACAATGTCATATTAAAGTACGT AGAAAGAACATTTTTGAGGATGCTTATCAAGAAATTATGAGACAAACCCCAGAAGATTTA AAGAAAAGATTAATGATCAAGTTTGATGGTGAGGAAGGTTTAGATTACGGTGGTGTTTCC AGAGAATTTTTCTTTTTATTATCACATGAGATGTTTAATCCATTTTATTGTTTGTTTGAA TATTCTGCGTATGACAACTATACCATTCAAATAAATCCTAACAGTGGCATCAACCCCGAA CATTTGAACTATTTCAAATTCATTGGTAGAGTTGTGGGTCTTGGTGTTTTCCATAGAAGA TTTTTGGATGCATTCTTTGTAGGTGCACTTTACAAAATGATGCTACGTAAAAAAGTCGTA TTGCAAGATATGGAAGGTGTTGACGCAGAGGTGTATAACTCATTAAACTGGATGCTTGAG AATAGTATAGATGGTGTCTTGGATCTGACGTTCAGTGCCGACGATGAAAGATTCGGTGAA GTTGTAACAGTGGATTTGAAGCCAGATGGGAGAAATATTGAAGTTACTGATGGTAATAAG AAAGAATATGTCGAATTATATACCCAATGGAGAATTGTTGATAGAGTTCAAGAACAATTT AAGGCATTCATGGATGGTTTTAACGAATTAATCCCCGAAGACTTAGTAACTGTGTTTGAT GAGCGTGAACTAGAACTATTGATCGGTGGTATTGCGGAAATTGACATTGAAGATTGGAAG AAACACACTGATTATCGTGGTTACCAAGAGTCAGACGAGGTCATTCAATGGTTTTGGAAG TGTGTCAGTGAATGGGATAATGAACAAAGAGCCCGTTTATTGCAGTTCACCACTGGTACT TCTCGTATACCTGTCAACGGGTTTAAAGATTTGCAAGGCTCTGATGGTCCAAGAAGATTC ACTATTGAAAAAGCTGGTGAAGTACAACAATTGCCAAAATCTCACACATGTTTTAACAGA GTTGATTTGCCACAATACGTTGATTATGACAGCATGAAACAGAAGCTAACATTGGCCGTG GAAGAAACCATAGGGTTTGGTCAAGAATGA | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
| Pfam Domain Function | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Residues | 809 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Molecular Weight | 91815.63 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Theoretical pI | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| PDB File | show | ||||||||||||||||||||||||||||||||||||||||||||||||
| Signalling Regions | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Sequence | >E3 ubiquitin-protein ligase RSP5 MPSSISVKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDI NENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDLKK SNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTTRTNGHSTSSTRNHSTSH PSRGTAQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTD NFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELERRQHRGRTLPGGSSDNSSVT VQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWV DPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRL PSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDL KKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPE HLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLE NSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQF KAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWK CVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNR VDLPQYVDYDSMKQKLTLAVEETIGFGQE | ||||||||||||||||||||||||||||||||||||||||||||||||
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| External Links |
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| General Reference | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||