Phosphatidylserine decarboxylase proenzyme 1, mitochondrial (P39006)

Identification
NamePhosphatidylserine decarboxylase proenzyme 1, mitochondrial
Synonyms
  • Phosphatidylserine decarboxylase 1 beta chain
  • Phosphatidylserine decarboxylase 1 alpha chain
Gene NamePSD1
Enzyme Class
Biological Properties
General FunctionInvolved in phosphatidylserine decarboxylase activity
Specific FunctionMay be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine
Cellular LocationMitochondrion inner membrane
SMPDB Pathways
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycerophospholipid metabolismec00564 Map00564
SMPDB ReactionsNot Available
KEGG Reactions
PC(14:0/16:0) → PE(14:0/16:1(9Z)) + Carbon dioxide
Metabolites
YMDB IDNameView
YMDB00912Carbon dioxideShow
GO Classification
Component
Not Available
Function
catalytic activity
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
phosphatidylserine decarboxylase activity
Process
metabolic process
organophosphate metabolic process
phospholipid metabolic process
phospholipid biosynthetic process
Gene Properties
Chromosome Locationchromosome 14
LocusYNL169C
Gene Sequence>1503 bp ATGTCAATTATGCCAGTTAAGAACGCCTTGGCGCAAGGGAGGACGCTCCTCATGGGGAGG ATGCCTGCTGTAAAGTTTTCTACAAGAATGCAATTAAGAAATAGAACTGCGGTGCTATGG AATAGAAAGTTTTCCACGCGTCTTTTCGTTCAGCAACGACGCAGTTCTGGAGAGATTGTG GATCGTGCCAAAGCTGCTGCCGCAAATAGCGGAAGAAAACAGGTCTCCATGAAATGGGTT GTTTTAACTAGTTTCACCATTGTTCTAGGAACCATTTTACTAGTGTCAAGGAATGATAGT ACAGAGGAGGATGCTACAGAGGGCAAAAAAGGGAGAAGGACAAGAAAAATCAAAATATTT AACAATAATTGGCTCTTTTTCTGCTATTCTACTTTACCGCTGAATGCGATGTCTCGATTA TGGGGCCAAGTAAATTCTCTTACGTTACCCATTTGGGTTAGACCATGGGGTTACAGGTTA TATTCTTTCCTTTTTGGAGTTAACTTGGACGAGATGGAAGATCCTGATTTGACACATTAT GCAAATTTATCCGAATTTTTCTATCGTAACATAAAACCAGGCACACGTCCAGTAGCACAA GGCGAAGACGTTATAGCTTCTCCAAGTGATGGAAAGATTTTACAAGTTGGTATAATCAAC TCTGAAACTGGCGAAATCGAACAAGTCAAGGGAATGACATATTCCATCAAAGAATTCCTT GGCACTCACTCCCACCCCTTGATGTCTAAGAGTGCATCTAGTCTAGATTTGACTTCTGAT GAGGAAAAGCATAGAGAATTCGCCAGGGTAAATAGAATACAATTAGCGGGTTCCGAAGAC ACTGAACAGCCTCTTCTTAACTTTAAAAACGAGGGCGATCAATCTGTTCGAGAGTTCAAA CCAAGTGTGTCCAAAAATATACATCTTTTAAGTCAACTTTCTTTAAACTACTTCTCTAAT GGGTTTTCGTGCTCTGAGCCTCATGATACGGAACTTTTCTTTGCCGTCATTTATTTGGCT CCCGGTGATTACCATCATTTCCACTCTCCAGTTGACTGGGTTTGTAAGGTTCGCCGCCAT TTCCCAGGTGATTTATTCTCCGTGGCACCTTATTTCCAGCGTAACTTCCCTAATCTTTTC GTTCTAAATGAAAGAGTTGCTTTGTTGGGTAGTTGGAAGTACGGATTTTTTAGCATGACT CCTGTTGGTGCAACAAATGTTGGTTCAATCAAGTTGAATTTTGATCAAGAATTTGTGACA AATTCAAAGAGCGACAAACACTTGGAACCACATACCTGCTACCAGGCAGTATATGAGAAT GCAAGTAAAATATTGGGAGGGATGCCTTTGGTTAAGGGTGAAGAAATGGGTGGCTTTGAA TTGGGTAGCACTGTTGTACTTTGTTTTGAAGCTCCCACTGAATTTAAGTTCGATGTTAGG GTTGGTGATAAGGTTAAGATGGGACAGAAATTAGGCATAATTGGAAAGAATGATTTAAAA TGA
Protein Properties
Pfam Domain Function
Protein Residues500
Protein Molecular Weight56594.39844
Protein Theoretical pI9.54
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Phosphatidylserine decarboxylase proenzyme 1, mitochondrial MSIMPVKNALAQGRTLLMGRMPAVKFSTRMQLRNRTAVLWNRKFSTRLFVQQRRSSGEIV DRAKAAAANSGRKQVSMKWVVLTSFTIVLGTILLVSRNDSTEEDATEGKKGRRTRKIKIF NNNWLFFCYSTLPLNAMSRLWGQVNSLTLPIWVRPWGYRLYSFLFGVNLDEMEDPDLTHY ANLSEFFYRNIKPGTRPVAQGEDVIASPSDGKILQVGIINSETGEIEQVKGMTYSIKEFL GTHSHPLMSKSASSLDLTSDEEKHREFARVNRIQLAGSEDTEQPLLNFKNEGDQSVREFK PSVSKNIHLLSQLSLNYFSNGFSCSEPHDTELFFAVIYLAPGDYHHFHSPVDWVCKVRRH FPGDLFSVAPYFQRNFPNLFVLNERVALLGSWKYGFFSMTPVGATNVGSIKLNFDQEFVT NSKSDKHLEPHTCYQAVYENASKILGGMPLVKGEEMGGFELGSTVVLCFEAPTEFKFDVR VGDKVKMGQKLGIIGKNDLK
References
External Links
ResourceLink
Saccharomyces Genome Database PSD1
Uniprot IDP39006
Uniprot NamePSD1_YEAST
GenBank Gene IDL20973
Genebank Protein ID414845
General Reference
  • Clancey, C. J., Chang, S. C., Dowhan, W. (1993). "Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant." J Biol Chem 268:24580-24590.8227017
  • Trotter, P. J., Pedretti, J., Voelker, D. R. (1993). "Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele." J Biol Chem 268:21416-21424.8407984
  • Philippsen, P., Kleine, K., Pohlmann, R., Dusterhoft, A., Hamberg, K., Hegemann, J. H., Obermaier, B., Urrestarazu, L. A., Aert, R., Albermann, K., Altmann, R., Andre, B., Baladron, V., Ballesta, J. P., Becam, A. M., Beinhauer, J., Boskovic, J., Buitrago, M. J., Bussereau, F., Coster, F., Crouzet, M., D'Angelo, M., Dal Pero, F., De Antoni, A., Del Rey, F., Doignon, F., Domdey, H., Dubois, E., Fiedler, T., Fleig, U., Floeth, M., Fritz, C., Gaillardin, C., Garcia-Cantalejo, J. M., Glansdorff, N. N., Goffeau, A., Gueldener, U., Herbert, C., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hinni, K., Iraqui Houssaini, I., Jacquet, M., Jimenez, A., Jonniaux, J. L., Karpfinger, L., Lanfranchi, G., Lepingle, A., Levesque, H., Lyck, R., Maftahi, M., Mallet, L., Maurer, K. C., Messenguy, F., Mewes, H. W., Mosti, D., Nasr, F., Nicaud, J. M., Niedenthal, R. K., Pandolfo, D., Pierard, A., Piravandi, E., Planta, R. J., Pohl, T. M., Purnelle, B., Rebischung, C., Remacha, M., Revuelta, J. L., Rinke, M., Saiz, J. E., Sartorello, F., Scherens, B., Sen-Gupta, M., Soler-Mira, A., Urbanus, J. H., Valle, G., Van Dyck, L., Verhasselt, P., Vierendeels, F., Vissers, S., Voet, M., Volckaert, G., Wach, A., Wambutt, R., Wedler, H., Zollner, A., Hani, J. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature 387:93-98.9169873
  • Nasr, F., Becam, A. M., Herbert, C. J. (1996). "The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase." Yeast 12:169-175.8686380
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278