Identification
Name2-deoxyglucose-6-phosphate phosphatase 1
Synonyms
  • 2-DOG-6-P 1
  • 2-deoxyglucose-6-phosphatase 1
Gene NameDOG1
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionActive on 2-DOG-6P, also very active on fructose-1P
Cellular LocationCytoplasmic
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB002942-deoxy-D-glucoseShow
YMDB008402-deoxy-D-glucose 6-phosphateShow
YMDB00890waterShow
YMDB00907phosphateShow
GO Classification
Component
Not Available
Function
hydrolase activity
catalytic activity
Process
metabolic process
Gene Properties
Chromosome Locationchromosome 8
LocusYHR044C
Gene Sequence>741 bp ATGGCAGAATTTTCAGCTGATCTATGTCTTTTTGACCTAGATGGTACCATAGTGAGTACA ACAGTGGCCGCAGAGAAAGCATGGACCAAGTTGTGTTACGAATACGGTGTTGATCCTTCC GAGTTATTTAAGCATTCTCATGGTGCAAGAACACAAGAGGTTTTGAGAAGGTTTTTCCCT AAATTGGATGATACAGACAATAAAGGTGTTCTTGCTCTAGAAAAAGATATTGCCCATAGT TACTTGGACACAGTAAGCCTTATTCCTGGTGCAGAGAACTTACTGTTATCGTTAGATGTA GATACTGAGACTCAAAAAAAGTTACCTGAAAGGAAATGGGCTATCGTTACCTCTGGTTCT CCATATTTGGCATTTTCATGGTTCGAGACAATATTGAAAAATGTTGGAAAGCCCAAAGTT TTCATTACTGGGTTTGACGTGAAGAACGGTAAGCCTGATCCCGAGGGTTATTCAAGAGCT CGTGATTTATTGCGTCAAGATTTGCAATTAACTGGTAAACAGGATCTGAAGTATGTTGTC TTCGAAGATGCACCCGTGGGCATAAAGGCCGGCAAAGCAATGGGCGCCATTACTGTGGGT ATAACATCCTCGTATGACAAGAGCGTTTTATTTGACGCAGGAGCAGATTATGTAGTCTGT GATTTGACACAGGTTTCCGTGGTTAAGAACAATGAAAACGGTATTGTCATCCAGGTAAAC AACCCTTTGACAAGGGCCTGA
Protein Properties
Pfam Domain Function
Protein Residues246
Protein Molecular Weight27099.59961
Protein Theoretical pI4.99
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>2-deoxyglucose-6-phosphate phosphatase 1 MAEFSADLCLFDLDGTIVSTTVAAEKAWTKLCYEYGVDPSELFKHSHGARTQEVLRRFFP KLDDTDNKGVLALEKDIAHSYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGS PYLAFSWFETILKNVGKPKVFITGFDVKNGKPDPEGYSRARDLLRQDLQLTGKQDLKYVV FEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVSVVKNNENGIVIQVN NPLTRA
References
External Links
ResourceLink
Saccharomyces Genome Database DOG1
Uniprot IDP38774
Uniprot NameDOG1_YEAST
GenBank Gene IDAY558516
Genebank Protein ID45270922
General Reference
  • Sanz, P., Randez-Gil, F., Prieto, J. A. (1994). "Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast." Yeast 10:1195-1202.7754708
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Randez-Gil, F., Blasco, A., Prieto, J. A., Sanz, P. (1995). "DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed." Yeast 11:1233-1240.8553694
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106