Identification |
---|
Name | Inositol monophosphatase 1 |
---|
Synonyms | - IMP 1
- IMPase 1
- Inositol-1(or 4)-monophosphatase 1
|
---|
Gene Name | INM1 |
---|
Enzyme Class | |
---|
Biological Properties |
---|
General Function | Involved in inositol or phosphatidylinositol phosphatase activity |
---|
Specific Function | Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides |
---|
Cellular Location | Cytoplasm. Nucleus |
---|
SMPDB Pathways | |
---|
KEGG Pathways | Inositol phosphate metabolism | ec00562 | |
|
---|
SMPDB Reactions | |
---|
KEGG Reactions | |
---|
Metabolites | YMDB ID | Name | View |
---|
YMDB00173 | Myoinositol | Show | YMDB00714 | 1D-myo-inositol 1-phosphate | Show | YMDB00715 | 1D-myo-inositol 3-phosphate | Show | YMDB00792 | Myo-inositol 1-phosphate | Show | YMDB00890 | water | Show | YMDB00907 | phosphate | Show | YMDB16136 | D-Myo-inositol 4-phosphate | Show | YMDB16145 | Phosphoric acid | Show |
|
---|
GO Classification | Component |
---|
Not Available | Function |
---|
hydrolase activity | hydrolase activity, acting on ester bonds | phosphoric ester hydrolase activity | phosphatase activity | inositol or phosphatidylinositol phosphatase activity | catalytic activity | Process |
---|
Not Available |
|
---|
Gene Properties |
---|
Chromosome Location | chromosome 8 |
---|
Locus | YHR046C |
---|
Gene Sequence | >YHR046C INM1 SGDID:S000001088, Chr VIII from 198285-197398, reverse complement, Verified ORF, "Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of
ATGACCATTGATCTAGCTTCTATCGAGAAATTCCTCTGTGAACTGGCTACTGAAAAAGTA
GGACCAATCATCAAATCCAAGTCCGGCACTCAAAAGGATTATGACTTGAAGACTGGCTCC
AGGAGCGTTGATATTGTAACTGCTATCGATAAACAGGTCGAAAAGTTAATTTGGGAATCG
GTAAAAACCCAATATCCAACTTTCAAGTTTATTGGAGAGGAAAGTTATGTGAAAGGGGAG
ACCGTGATTACTGATGATCCTACCTTTATTATTGATCCAATTGATGGGACTACAAACTTT
GTTCATGATTTCCCATTTAGCTGTACCTCTCTTGGGCTCACAGTAAACAAAGAGCCCGTA
GTAGGCGTTATATATAATCCTCACATTAATCTTCTGGTATCCGCTTCTAAAGGAAATGGG
ATGAGAGTTAACAACAAGGACTATGACTATAAATCAAAATTGGAATCTATGGGTTCTCTA
ATACTAAATAAATCCGTAGTGGCATTACAGCCAGGTTCCGCTAGAGAGGGAAAGAATTTT
CAGACAAAAATGGCCACATATGAAAAATTACTATCATGTGATTACGGTTTTGTTCATGGA
TTCAGAAATTTAGGATCATCTGCAATGACAATGGCATATATTGCTATGGGGTACCTTGAT
AGTTATTGGGATGGTGGTTGCTATTCGTGGGACGTGTGTGCTGGATGGTGTATTTTGAAA
GAAGTGGGCGGTCGTGTAGTAGGTGCCAATCCAGGTGAATGGAGTATTGATGTCGACAAT
AGGACATATTTGGCTGTGAGGGGAACAATTAATAACGAAAGTGACGAACAAACAAAATAT
ATCACAGACTTTTGGAACTGTGTTGATGGCCATTTGAAATATGACTGA |
---|
Protein Properties |
---|
Pfam Domain Function | |
---|
Protein Residues | 295 |
---|
Protein Molecular Weight | 32823.0 |
---|
Protein Theoretical pI | 4.92 |
---|
Signalling Regions | |
---|
Transmembrane Regions | |
---|
Protein Sequence | >Inositol monophosphatase 1
MTIDLASIEKFLCELATEKVGPIIKSKSGTQKDYDLKTGSRSVDIVTAIDKQVEKLIWES
VKTQYPTFKFIGEESYVKGETVITDDPTFIIDPIDGTTNFVHDFPFSCTSLGLTVNKEPV
VGVIYNPHINLLVSASKGNGMRVNNKDYDYKSKLESMGSLILNKSVVALQPGSAREGKNF
QTKMATYEKLLSCDYGFVHGFRNLGSSAMTMAYIAMGYLDSYWDGGCYSWDVCAGWCILK
EVGGRVVGANPGEWSIDVDNRTYLAVRGTINNESDEQTKYITDFWNCVDGHLKYD |
---|
References |
---|
External Links | |
---|
General Reference | - Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
- Lopez, F., Leube, M., Gil-Mascarell, R., Navarro-Avino, J. P., Serrano, R. (1999). "The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair." Mol Microbiol 31:1255-1264.10096091
- Navarro-Avino, J. P., Belles, J. M., Serrano, R. (2003). "Yeast inositol mono- and trisphosphate levels are modulated by inositol monophosphatase activity and nutrients." Biochem Biophys Res Commun 302:41-45.12593845
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
|
---|