3-ketoacyl-CoA reductase (P38286)

Identification
Name3-ketoacyl-CoA reductase
Synonyms
  • 3-ketoreductase
  • KAR
  • Microsomal beta-keto-reductase
Gene NameIFA38
Enzyme Class
Biological Properties
General FunctionInvolved in oxidoreductase activity
Specific FunctionComponent of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids
Cellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein (Potential)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
3-oxooctadecanoyl-CoA + NADPH + hydron ↔ NADP + 3-hydroxyoctadecanoyl-CoA
3-oxotetradecanoyl-CoA + NADPH + hydron ↔ NADP + (S)-3-hydroxytetradecanoyl-CoA
Metabolites
YMDB IDNameView
YMDB00426NADPHShow
YMDB00427NADPShow
YMDB00468(S)-3-hydroxypalmitoyl-CoAShow
YMDB004713-hydroxyoctadecanoyl-CoAShow
YMDB00473(S)-3-hydroxytetradecanoyl-CoAShow
YMDB004763-oxopalmitoyl-CoAShow
YMDB004773-oxooctadecanoyl-CoAShow
YMDB004783-oxotetradecanoyl-CoAShow
YMDB007313-hydroxyicosanoyl-CoAShow
YMDB007323-oxoicosanoyl-CoAShow
YMDB007333-oxodocosanoyl-CoAShow
YMDB007343-hydroxydocosanoyl-CoAShow
YMDB007353-oxotetracosanoyl-CoAShow
YMDB007363-hydroxytetracosanoyl-CoAShow
YMDB00862hydronShow
YMDB00959(S)-3-hydroxyhexacosanoyl-CoAShow
YMDB009603-oxohexacosanoyl-CoAShow
GO Classification
Component
Not Available
Function
catalytic activity
binding
oxidoreductase activity
Process
oxidation reduction
metabolic process
Gene Properties
Chromosome Locationchromosome 2
LocusYBR159W
Gene Sequence>1044 bp ATGACTTTTATGCAACAGCTTCAAGAGGCTGGGGAAAGATTTAGGTGTATCAATGGTCTT TTATGGGTTGTTTTTGGGCTTGGTGTCTTAAAATGTACAACGTTATCACTTAGATTTTTA GCTCTTATTTTTGATCTTTTTTTACTACCAGCAGTCAATTTCGACAAGTATGGTGCTAAA ACTGGTAAATACTGTGCTATCACTGGTGCAAGTGACGGTATTGGTAAAGAATTTGCTAGA CAAATGGCGAAACGTGGCTTCAACTTGGTATTGATCTCGAGAACGCAATCTAAATTGGAG GCTTTACAAAAAGAACTAGAAGATCAACATCATGTCGTTGTAAAGATTCTAGCCATTGAC ATTGCGGAGGATAAAGAATCCAACTATGAATCCATTAAGGAATTGTGTGCGCAGTTACCA ATCACCGTTTTGGTCAATAATGTTGGTCAATCACACTCCATTCCTGTTCCATTTTTGGAA ACAGAAGAGAAGGAGCTTAGAAATATTATCACTATCAATAACACTGCTACATTATTAATT ACACAAATCATTGCACCAAAGATTGTGGAAACTGTGAAAGCTGAAAACAAGAAGTCGGGT ACTCGTGGTTTGATCTTAACCATGGGCTCATTTGGTGGTCTGATTCCCACCCCACTTTTG GCTACATACAGTGGTTCGAAATCATTCTTACAAGGTTGGTCTAACTCTTTGGCTGGGGAA TTATCTAAAGATGCTATCGATGTTGAATTAATCATTTCATATTTGGTCACTAGCTCGATG TCTAAAATCAGAAGATCATCTTTAATGATCCCAAATCCACAACAGTTTGTAAAATCCACT TTAAGAAGCGTTGGCAGACGCTGCGGCTCTCAAGAAAGATACGCTACTATGACCCCTTAC TGGGCGCACGCAGTGTATCAATTTGTAATTACAGAGACCTTTGGCGTTTACTCTAAGATT GTTAACTCCATTAATTATTCCTTCCATAAATCTATCAGAATTAGAGCCTTAAAAAAAGCC GCAAGACAGGTTAAAAAGGAATAG
Protein Properties
Pfam Domain Function
Protein Residues347
Protein Molecular Weight38707.80078
Protein Theoretical pI10.01
Signalling Regions
  • None
Transmembrane Regions
  • 20-40
Protein Sequence>3-ketoacyl-CoA reductase MTFMQQLQEAGERFRCINGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFDKYGAK TGKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAID IAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLI TQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGE LSKDAIDVELIISYLVTSSMSKIRRSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPY WAHAVYQFVITETFGVYSKIVNSINYSFHKSIRIRALKKAARQVKKE
References
External Links
ResourceLink
Saccharomyces Genome Database IFA38
Uniprot IDP38286
Uniprot NameMKAR_YEAST
GenBank Gene IDAY557868
Genebank Protein ID45269627
General Reference
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