Very long-chain fatty acid transport protein (P38225)

Identification

Name

Very long-chain fatty acid transport protein

Synonyms

Not Available

Gene Name

FAT1

Enzyme Class

Not Available

Biological Properties

General Function

Involved in catalytic activity

Specific Function

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised

Cellular Location

Membrane; Multi-pass membrane protein (Potential)

SMPDB Pathways

Biosynthesis of unsaturated fatty acids

PW002403

KEGG Pathways

Biosynthesis of unsaturated fatty acids

ec01040

SMPDB Reactions

Palmitic acid + Adenosine triphosphate + Coenzyme A → Adenosine monophosphate + Pyrophosphate + Palmityl-CoA

KEGG Reactions

Adenosine triphosphate + lignoceric acid + Coenzyme A ↔ Adenosine monophosphate + Pyrophosphate + Tetracosanoyl-CoA

Adenosine triphosphate + cerotic acid + Coenzyme A ↔ Adenosine monophosphate + Pyrophosphate + hexacosanoyl-CoA

Metabolites

YMDB ID	Name	View
YMDB00045	Coenzyme A	Show
YMDB00069	Palmitic acid	Show
YMDB00097	Adenosine monophosphate	Show
YMDB00109	Adenosine triphosphate	Show
YMDB00219	Pyrophosphate	Show
YMDB00301	Palmityl-CoA	Show
YMDB00537	hexacosanoyl-CoA	Show
YMDB00684	lignoceric acid	Show
YMDB00785	cerotic acid	Show
YMDB00909	Tetracosanoyl-CoA	Show

GO Classification

Component
Not Available
Function
catalytic activity
Process
metabolic process

Gene Properties

Chromosome Location

chromosome 2

Locus

YBR041W

Gene Sequence

>2010 bp ATGTCTCCCATACAGGTTGTTGTCTTTGCCTTGTCAAGGATTTTCCTGCTATTATTCAGA CTTATCAAGCTAATTATAACCCCTATCCAGAAATCACTGGGTTATCTATTTGGTAATTAT TTTGATGAATTAGACCGTAAATATAGATACAAGGAGGATTGGTATATTATTCCTTACTTT TTGAAAAGCGTGTTTTGTTATATCATTGATGTGAGAAGACATAGGTTTCAAAACTGGTAC TTATTTATTAAACAGGTCCAACAAAATGGTGACCATTTAGCGATTAGTTACACCCGTCCC ATGGCCGAAAAGGGAGAATTTCAACTCGAAACCTTTACGTATATTGAAACTTATAACATA GTGTTGAGATTGTCTCATATTTTGCATTTTGATTATAACGTTCAGGCCGGTGACTACGTG GCAATCGATTGTACTAATAAACCTCTTTTCGTATTTTTATGGCTTTCTTTGTGGAACATT GGGGCTATTCCAGCTTTTTTAAACTATAATACTAAAGGCACTCCGCTGGTTCACTCCCTA AAGATTTCCAATATTACGCAGGTATTTATTGACCCTGATGCCAGTAATCCGATCAGAGAA TCGGAAGAAGAAATCAAAAACGCACTTCCTGATGTTAAATTAAACTATCTTGAAGAACAA GACTTAATGCATGAACTTTTAAATTCGCAATCACCGGAATTCTTACAACAAGACAACGTT AGGACACCACTAGGCTTGACCGATTTTAAACCCTCTATGTTAATTTATACATCTGGAACC ACTGGTTTGCCTAAATCCGCTATTATGTCTTGGAGAAAATCCTCCGTAGGTTGTCAAGTT TTTGGTCATGTTTTACATATGACTAATGAAAGCACTGTGTTCACAGCCATGCCATTGTTC CATTCAACTGCTGCCTTATTAGGTGCGTGCGCCATTCTATCTCACGGTGGTTGCCTTGCG TTATCGCATAAATTTTCTGCCAGTACATTTTGGAAGCAAGTTTATTTAACAGGAGCCACG CACATCCAATATGTCGGAGAAGTCTGTAGATACCTGTTACATACGCCAATTTCTAAGTAT GAAAAGATGCATAAGGTGAAGGTTGCTTATGGTAACGGGCTGAGACCTGACATCTGGCAG GACTTCAGGAAGAGGTTCAACATAGAAGTTATTGGTGAATTCTATGCCGCAACTGAAGCT CCTTTTGCTACAACTACCTTCCAGAAAGGTGACTTTGGAATTGGCGCATGTAGGAACTAT GGTACTATAATTCAATGGTTTTTGTCATTCCAACAAACATTGGTAAGGATGGACCCAAAT GACGATTCCGTTATATATAGAAATTCCAAGGGTTTCTGCGAAGTGGCCCCTGTTGGCGAA CCAGGAGAAATGTTAATGAGAATCTTTTTCCCTAAAAAACCAGAAACATCTTTTCAAGGT TATCTTGGTAATGCCAAGGAAACAAAGTCCAAAGTTGTGAGGGATGTCTTCAGACGTGGC GATGCTTGGTATAGATGTGGAGATTTATTAAAAGCGGACGAATATGGATTATGGTATTTC CTTGATAGAATGGGTGATACTTTCAGATGGAAATCTGAAAATGTTTCCACTACTGAAGTA GAAGATCAGTTGACGGCCAGTAACAAAGAACAATATGCACAAGTTCTAGTTGTTGGTATT AAAGTACCTAAATATGAAGGTAGAGCTGGTTTTGCAGTTATTAAACTAACTGACAACTCT CTTGACATCACTGCAAAGACCAAATTATTAAATGATTCCTTGAGCCGGTTAAATCTACCG TCTTATGCTATGCCCCTATTTGTTAAATTTGTTGATGAAATTAAAATGACAGATAATCAT AAAATTTTGAAGAAGGTTTATAGAGAGCAAAAATTACCAAAGGGTTTGGATGGAAATGAC ACTATTTTTTGGCTCAAGAATTACAAGCGCTATGAAGTCTTGACCGCTGCTGATTGGGAA GCCATCGATGCACAAACAATTAAATTATGA

Protein Properties

Pfam Domain Function

AMP-binding (PF00501 )

Protein Residues

669

Protein Molecular Weight

77140.29688

Protein Theoretical pI

8.52

Signalling Regions

None

Transmembrane Regions

6-26
54-71
149-169
293-313

Protein Sequence

>Very long-chain fatty acid transport protein MSPIQVVVFALSRIFLLLFRLIKLIITPIQKSLGYLFGNYFDELDRKYRYKEDWYIIPYF LKSVFCYIIDVRRHRFQNWYLFIKQVQQNGDHLAISYTRPMAEKGEFQLETFTYIETYNI VLRLSHILHFDYNVQAGDYVAIDCTNKPLFVFLWLSLWNIGAIPAFLNYNTKGTPLVHSL KISNITQVFIDPDASNPIRESEEEIKNALPDVKLNYLEEQDLMHELLNSQSPEFLQQDNV RTPLGLTDFKPSMLIYTSGTTGLPKSAIMSWRKSSVGCQVFGHVLHMTNESTVFTAMPLF HSTAALLGACAILSHGGCLALSHKFSASTFWKQVYLTGATHIQYVGEVCRYLLHTPISKY EKMHKVKVAYGNGLRPDIWQDFRKRFNIEVIGEFYAATEAPFATTTFQKGDFGIGACRNY GTIIQWFLSFQQTLVRMDPNDDSVIYRNSKGFCEVAPVGEPGEMLMRIFFPKKPETSFQG YLGNAKETKSKVVRDVFRRGDAWYRCGDLLKADEYGLWYFLDRMGDTFRWKSENVSTTEV EDQLTASNKEQYAQVLVVGIKVPKYEGRAGFAVIKLTDNSLDITAKTKLLNDSLSRLNLP SYAMPLFVKFVDEIKMTDNHKILKKVYREQKLPKGLDGNDTIFWLKNYKRYEVLTAADWE AIDAQTIKL

References

External Links

Resource	Link
Saccharomyces Genome Database	FAT1
Uniprot ID	P38225
Uniprot Name	FAT1_YEAST
GenBank Gene ID	AF065148
Genebank Protein ID	3152696

General Reference

Faergeman, N. J., DiRusso, C. C., Elberger, A., Knudsen, J., Black, P. N. (1997). "Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids." J Biol Chem 272:8531-8538.9079682
Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106