Phosphatidylinositol 4-kinase STT4 (P37297)

Identification
NamePhosphatidylinositol 4-kinase STT4
Synonyms
  • PI4-kinase
  • PtdIns-4-kinase
Gene NameSTT4
Enzyme Class
Biological Properties
General FunctionInvolved in binding
Specific FunctionActs on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway
Cellular LocationNot Available
SMPDB Pathways
Inositol phosphate metabolismPW002495 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: cell wall stress test 1PW007861 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Inositol phosphate metabolismec00562 Map00562
SMPDB Reactions
PI(18:0/20:4(5Z,8Z,11Z,14Z)) + phosphate → PIP(18:0/20:4(5Z,8Z,11Z,14Z))
KEGG Reactions
Adenosine triphosphate + 1-Phosphatidyl-D-myo-inositol → 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP
Metabolites
YMDB IDNameView
YMDB00109Adenosine triphosphateShow
YMDB002301-Phosphatidyl-D-myo-inositolShow
YMDB00907phosphateShow
YMDB00914ADPShow
YMDB16196PI(18:0/20:4(5Z,8Z,11Z,14Z))Show
YMDB16197PIP(18:0/20:4(5Z,8Z,11Z,14Z))Show
GO Classification
Component
Not Available
Function
binding
kinase activity
phosphotransferase activity, alcohol group as acceptor
inositol or phosphatidylinositol kinase activity
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
organophosphate metabolic process
phospholipid metabolic process
intracellular signal transduction
second-messenger-mediated signaling
phosphoinositide-mediated signaling
glycerophospholipid metabolic process
metabolic process
phosphoinositide metabolic process
phosphoinositide phosphorylation
Gene Properties
Chromosome Locationchromosome 12
LocusYLR305C
Gene Sequence>5703 bp ATGAGATTTACCAGAGGATTGAAAGCCTCTTCATCTTTAAGAGCGAAAGCTATTGGAAGA CTAACTAAACTTTCGACGGGTGCACCAAATGATCAAAACAGTAATGGTACAACATTAGAT TTGATAACTCATACATTGCCTATTTTTTATTCCACAAATACGTCAAAGATATATACTATA CCACTTACATTGAGTGAATGGGAAGTACTAACTTCGCTTTGTGTTGCAATCCCTACCACG CTCGATCTGGTAGAGACAATGCTTAAAGAAATAATTGCGCCTTATTTTCTGGAAACTCCA AGACAAAGAATTTCAGATGTTCTGTCCTCGAAATTCAAGTTGGAACAGATGAGAAATCCG ATTGAATTGCTAACTTTCCAGCTGACTAAGTTTATGATTCAAGCTTGTGAACAGTATCCC GTTCTTTATGAAAATATAGGCGGCATCATTTCAACTTATTTTGAGCGTGTATTAAAGATT TTTACTATTAAACAATCTGGTCTACTATCATTAGTGGGCTTTATTAATGCATTTATCCAG TTTCCCAACTCTACAGAGCTTACTAAATTCACCTGGAAAAAGTTAGCGAAACTTGTGCTT CGTGGATCATTTCTAAACGAAGTTGATAAGATTTTGAATTCCTCAGCAACGTTTACCAAT GATTCAATCGTCCAGTATTACGATGCTGGAAATGAGCTATCCAGTGCCTACTTATTGGAA TTAATATCTCGCTTGCAAGTTTCGCTAATATCTCATCTGTTAAACACTTCACATGTCGGC GCCAACTTGAGTGAGTTCTTACTAAATCAACAATACCAATTTTACAAATTTGATCAAGAA GTAGCCGATGAAAACGATGATACGAAGTGTATTGATGACTTTTTTTTCAACGTAAGAAGC AATAAACAGTTTTTTACAGACATGTGTAAAATTTCCCTGCAATTTTGTTCTGAGTCACAT ATTCTCGACCTATCTACAGACAACCGTGCAAGATTTTCTTTTGATACTCGAGCCCACTAC CTACAAACGCTATGTTTAATTCCGTTTATAGAAGATACAGAAAGCGAGCTTTTTGAAAGT TTTACAAACGTTGTTTCTGAATCTATTGATAAATTTTTCTTATCTGATGTCGTTACACCA TCTTTGATAAAAGCAATTGTAGCTTCTGCCTCATTACTGAATTTTTTCACGGAAAAATTG TCATTAACTCTGATTCGTATGTTTCCTTTATTGGTAGCGTCTCCACATATCACGACTGAA ACAGTTAATGATGTTGCAAAAATATTCACCACAGGGTTATACCCTCTAAATGAAGATGCA ATTGTGAGTACAATTTATTCCATGAACAACTTATTAGCTGTTTCCGAGGACGGATCGCCC GTCCCGGTGCTCCGTGAGCGCCAATTAACAATAACATCTGGAAAAAATATTGAGAAAGAC TACTTTCCCTTGCGAAATTCATCTGCCAGTTTGGATGGCACTGGTGCTCTGCTCGGAAAT ACAACTGTGGGCCAACTTTCCTCCCATGATGTCAATAGTGGAGCTACTATGACATACCAT GCCTCTTTGATATCTAATTGTGTGGCTGCAACGACTACAATCGCCTCATACTATAACACC CAAAGCATAACAGCTTTGACTATCTCTATTCTTACGCAAAAAGTTAATTCTATGTCAAAG GAATTAGACGGTGTTATTTTGAATTCTTTGGCAAGACTGGCTCCGAATACTTCACTGACA GAATTTTCGCTTTTACTAAAGTTCTTCAAATCGAGAACTGTTATTGCAACAAAAATTGAT GATAGCGCACTATTGAAAAATATTATTAAAGCGAAATGTGTGATATCAAAAGAATTGTTG GCCAGGCATTTTTCAAGTGACTTATATTTCATGTATCTTCATGATCTATTGGACTCAATT ATTGCCAGTGGGGAAGTAGAACGATTGGAACATCACAGACCTCAAACGGAGATTTCCCGT GTTGCTGATCAAATCGCTACCTACTTAGAGCCCCTCGCCGCTCTACTACCTGTTCCAGGC GATACGCCATTGGACATCAATAAGGATGAAGTCACTACAAACAAGTTTAGGAACGCCTGG TTTAATTTTGTCATCCATGGGTACCACTTGGGCGGGCCTATTGTCAAACGAAATTTTTCT TTCTTATTAACTATTGCCTATAATTCACCACCGCTGGCTTCTGAATTTCCTGCTAATAAC AAGGAGCTTTCATTGGAAATGAATACAATTTTGCGCCGCGGTTCATCTAACGAAAATATC AAACAACAAAAACAGCAGATAACCGAATATTTCAATACCAATATTGTTCAGTACAGAACA ACTTCATCGTCTAAAATCATGTTTTTAGCGGCTGCCGTTCTTCTAGAAACGATAAGATGC GAGGCAGGTGATTGTTCGAAGACTCTACTGTACTTCTCAGACCCCTCCATTCTTTCCGGT TCAATTGAGAAGTGTATTGCAGTTTTGTCGGTTTCCATGATTAGAAAATATGCTAGGTTG ATTCAAAAGGGTAACGATGCCATATTCAACTCCAAAATGATTGCTCAACAACTTAATAAC TTGCTACTTTGCCTTTCTCATAGGGAACCAACTTTGCAGGATGCCGCTTTTCATGCCTGT GAAATATTTATCAGATCTATTCCATCATCGTTATGTCATCATTTGTCTCTCTACACCTTA TTAGATATGTTAACAGCCCTATTTGATAGTATCTTGGACTCAGAGGCGCATAAATTTGAA CCACGGTATGAATTTAAATTAAAACATTCTAAGACAACAATATTGGTTCCAAGCTCATCG TCCTGGCGCGCTACGACACTATCAAGATTGCACAAGTCAGCTAAAGAATGGGTAAGAATT CTATTGAATAGAAGCAACCAGGATACTAAGATTTTGTTGCAATCATACATATCAGATCTC GGTGAGTACAGCAGGCTAAATTCTGTTGAATTTGGTGTCTCATTTGCCATGGATATGGCT GGTTTGATTTTACCTGCAGATAAGGAATTATCAAGGCTTACTTATTATGGTCCAGAGAAA CCTAACACGATTTCTGGATTTATATCTTTACATTCTTGGAGGTCAAAATATCTTTTCGAT ACCGCTATTACATCATCACCAGAGGATATCAAAAGGCAAATAGGTATTTCCACTCAAAAC ATAAGAAAAAATTTGACCTTAGGAAATAAGATTATAACTAAAGACGTAACTGATTTTCTT GATATGGCTACCGCGTTGTTAATTCTTGGCAATGGTGCACCAGCGTCATTGATATATGAT ATTGTGCACATCCCGTTCGAAGTCTTCACCTCTGCATCTTTAAAGATTGCTACAAACGTA TGGTTAACAATCATAACTGAGAAGCCCGAAGTTGCACATTTGCTTTTAGTTGAAGTATGC TATTGCTGGATGCGCTCCATTGATGACAATATTGGTCTCTATTCTCGCGATCATGACTTA AAGGGCGAAGAATACCAAAAAATGGAATATTCCCCTTACGACAAAGCAGGTATCAACAGA GATGCAAAAAATGCATCCCAAGCTATGCAACCACATCTTCATGTTATTAAATTTTTTGCT TCCCATTTCGAGGGCACACTATTTCAAAGTGACTTTTTATTGAAAATTTTCACGAAATGT GCGCTTTATGGTATCAAGAATCTGTATAAGGCTTCACTACACCCGTTCGCTAGAATGATT CGCCACGAATTATTGTTATTCGCGACTCTCGTACTAAACGCAAGTTATAAGCAGGGATCC AAGTATATGGGCCGTTTGTCGCAAGAAATCACAAACGGTGCCCTAAGTTGGTTTAAAAGA CCAGTAGCGTGGCCATTCGGCTCAAATGAGCTGAAAATCAAAGCAGATTTATCTGTTACT AGGGACCTTTTCCTTCAGCTCAACAAATTAAGCTCGCTAATGTCACGTCATTGCGGGAAA GATTACAAGATCCTGAACTATTTCTTGGCAAGCGAAATCCAGCAGATTCAAACCTGGCTT ACTCCGACTGAGAAGATTGAAGGAGCCGACAGCAACGAGCTTACAAGCGATATCGTTGAA GCTACCTTTGCTAAAGATCCAACATTAGCAATAAATCTCTTACAACGATGTTATAGCAAG AAAGCTGAGGATGTTTTAGTGGGCTTAGTTGCAAAACATGCTTTAATGTGTGTGGGGTCC CCAAGTGCTCTTGACCTGTTCATAAAAGGAAGCCACCTGAGCAGTAAGAAAGACCTACAC GCAACCTTATACTGGGCGCCAGTGAGCCCGTTAAAATCTATCAACCTTTTCCTTCCCGAA TGGCAAGGTAATTCTTTTATCTTACAATTCAGCATATATTCGTTGGAATCACAAGATGTG AACTTGGCATTCTTCTATGTTCCTCAAATCGTACAATGTTTGAGATACGATAAAACCGGA TATGTCGAAAGATTGATTTTGGATACTGCGAAAATTAGTGTGTTATTTTCTCATCAAATA ATCTGGAATATGCTTGCAAACTGCTACAAGGATGATGAAGGTATACAAGAAGATGAAATC AAACCAACTCTAGATCGTATTAGGGAGCGTATGGTTTCAAGTTTCAGCCAATCTCATCGC GATTTTTACGAACGTGAATTTGAATTCTTCGACGAAGTAACTGGCATATCTGGTAAGTTG AAACCATACATAAAAAAAAGTAAGGCTGAAAAGAAACATAAGATCGATGAAGAAATGAGC AAAATTGAGGTGAAACCTGATGTTTATTTACCTTCTAATCCTGACGGTGTAGTTATTGAT ATTGATCGGAAGAGTGGTAAGCCACTTCAATCTCACGCAAAGGCGCCTTTTATGGCGACC TTTAAAATAAAGAAAGACGTAAAAGATCCTTTGACAGGTAAAAACAAGGAAGTTGAAAAA TGGCAAGCTGCTATCTTCAAAGTCGGTGATGACTGTAGGCAAGATGTTCTAGCGTTACAA TTGATCTCGCTATTTAGAACCATTTGGTCTAGTATTGGCTTGGATGTCTACGTTTTTCCC TACAGAGTTACTGCGACGGCACCGGGTTGTGGTGTCATCGATGTGCTACCCAATTCGGTA TCCCGTGATATGTTAGGACGTGAAGCTGTTAATGGATTATATGAATATTTCACTAGTAAA TTTGGTAATGAATCTACTATCGAATTTCAAAACGCACGAAACAACTTTGTTAAATCCTTA GCGGGATATAGCGTAATTTCGTATTTGTTGCAATTCAAGGATAGACATAATGGTAACATT ATGTACGATGATCAAGGACATTGTCTACATATCGATTTTGGGTTTATTTTTGATATTGTC CCAGGTGGTATCAAGTTTGAAGCAGTACCATTCAAGCTGACGAAAGAAATGGTTAAAGTG ATGGGAGGTTCGCCCCAGACCCCAGCGTATCTGGACTTTGAAGAACTTTGTATCAAGGCA TATCTAGCCGCCCGTCCGCACGTGGAGGCCATAATTGAGTGTGTAAATCCTATGTTAGGA AGCGGTCTCCCCTGCTTTAAGGGTCACAAGACAATTAGGAATCTAAGAGCAAGATTTCAA CCTCAAAAAACCGATCACGAAGCTGCACTATATATGAAGGCGCTAATCCGTAAAAGTTAT GAAAGTATATTCACTAAAGGTTATGATGAATTCCAAAGGCTCACAAATGGCATTCCGTAC TGA
Protein Properties
Pfam Domain Function
Protein Residues1900
Protein Molecular Weight214605.0
Protein Theoretical pI7.51
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Phosphatidylinositol 4-kinase STT4 MRFTRGLKASSSLRAKAIGRLTKLSTGAPNDQNSNGTTLDLITHTLPIFYSTNTSKIYTI PLTLSEWEVLTSLCVAIPTTLDLVETMLKEIIAPYFLETPRQRISDVLSSKFKLEQMRNP IELLTFQLTKFMIQACEQYPVLYENIGGIISTYFERVLKIFTIKQSGLLSLVGFINAFIQ FPNSTELTKFTWKKLAKLVLRGSFLNEVDKILNSSATFTNDSIVQYYDAGNELSSAYLLE LISRLQVSLISHLLNTSHVGANLSEFLLNQQYQFYKFDQEVADENDDTKCIDDFFFNVRS NKQFFTDMCKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTESELFES FTNVVSESIDKFFLSDVVTPSLIKAIVASASLLNFFTEKLSLTLIRMFPLLVASPHITTE TVNDVAKIFTTGLYPLNEDAIVSTIYSMNNLLAVSEDGSPVPVLRERQLTITSGKNIEKD YFPLRNSSASLDGTGALLGNTTVGQLSSHDVNSGATMTYHASLISNCVAATTTIASYYNT QSITALTISILTQKVNSMSKELDGVILNSLARLAPNTSLTEFSLLLKFFKSRTVIATKID DSALLKNIIKAKCVISKELLARHFSSDLYFMYLHDLLDSIIASGEVERLEHHRPQTEISR VADQIATYLEPLAALLPVPGDTPLDINKDEVTTNKFRNAWFNFVIHGYHLGGPIVKRNFS FLLTIAYNSPPLASEFPANNKELSLEMNTILRRGSSNENIKQQKQQITEYFNTNIVQYRT TSSSKIMFLAAAVLLETIRCEAGDCSKTLLYFSDPSILSGSIEKCIAVLSVSMIRKYARL IQKGNDAIFNSKMIAQQLNNLLLCLSHREPTLQDAAFHACEIFIRSIPSSLCHHLSLYTL LDMLTALFDSILDSEAHKFEPRYEFKLKHSKTTILVPSSSSWRATTLSRLHKSAKEWVRI LLNRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEK PNTISGFISLHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFL DMATALLILGNGAPASLIYDIVHIPFEVFTSASLKIATNVWLTIITEKPEVAHLLLVEVC YCWMRSIDDNIGLYSRDHDLKGEEYQKMEYSPYDKAGINRDAKNASQAMQPHLHVIKFFA SHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFATLVLNASYKQGS KYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLMSRHCGK DYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSK KAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPE WQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQI IWNMLANCYKDDEGIQEDEIKPTLDRIRERMVSSFSQSHRDFYEREFEFFDEVTGISGKL KPYIKKSKAEKKHKIDEEMSKIEVKPDVYLPSNPDGVVIDIDRKSGKPLQSHAKAPFMAT FKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFP YRVTATAPGCGVIDVLPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSL AGYSVISYLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKV MGGSPQTPAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQ PQKTDHEAALYMKALIRKSYESIFTKGYDEFQRLTNGIPY
References
External Links
ResourceLink
Saccharomyces Genome Database STT4
Uniprot IDP37297
Uniprot NameSTT4_YEAST
GenBank Gene IDD13717
Genebank Protein ID454207
General Reference
  • Yoshida, S., Ohya, Y., Goebl, M., Nakano, A., Anraku, Y. (1994). "A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae." J Biol Chem 269:1166-1172.8288577
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956