Vacuolar amino acid transporter 3 (P36062)

Identification
NameVacuolar amino acid transporter 3
SynonymsNot Available
Gene NameAVT3
Enzyme ClassNot Available
Biological Properties
General FunctionAmino acid transport and metabolism
Specific FunctionInvolved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine
Cellular LocationVacuole membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00002L-GlutamineShow
YMDB00038L-IsoleucineShow
YMDB00226L-AsparagineShow
YMDB00364L-TyrosineShow
YMDB00387L-LeucineShow
YMDB00862hydronShow
GO ClassificationNot Available
Gene Properties
Chromosome Locationchromosome 11
LocusYKL146W
Gene Sequence>2079 bp ATGAATGGAAAAGAGGTTTCAAGTGGCTCTGGAAGAACGCAGAGCAACAACAACAAAAAA AATAACAACGGAGGCAGTACAGGAATCTCGCATGCGTCTGGCTCACCTTTAACGGACGGC AACGGTGGCAATAGCAACGGTAATAGTAGAAGTAGAAGCAGAAGTAGAAAATCTAGTGGA ACTACAGGTGGTTTGCTAAAAAAGCCGCCGCTGCTTGTGAACAATGAAGCGGTGCATGCT AGCGTACCCGACGCGTCGCACACTTCCTGTAACAATGGCACGCTTGAAGTGAGCATAAAT AACCCTGAGCCACATGTGGTAGATGCCGTGGCACGCCACTTGATAAGAAACCCGAGTAAC AGCCTACAATTGCAAGGCGGAGACATTACAAGAGATCTGTATAAGTGGACAAACGACCAT CCTTCATCACCATCGCAGTATCAGTACCCAAGTCAACCTGCACTTTCCACCTCAATACCT TCACAAGCGCCCTCATTCTCGAATCGTAAAAGGTCTATGAGCTTTTCTGCCGCTTCTATA GCATCTTCCTCTCACCTTAACAACAACTCGGAGGCGAATGGGAATCCTCTAGCGGCAATA GGCCTGGCGCCCGCACCGATGACGCACGAAGAAATCAGGGCTCCTGGTGGATTCAGAAGA TCTTTTATAATACAGAAGCGCAGGAAACATAACGTTGATGCGCCCATACCGAATTTTTTC ACCAGGAACTTTATTGAATTTTTGACCTTGTATGGCCACTTCGCTGGTGAAGATTTATCG GAAGAAGAGGAGGAGGAGGAAGAAACTGAAGAGGAGCCAGAGGAGGAAGCTTTGGAAACG GAAAGCACCCAGCTAGTTTCTCGTGAACACGGGCGCCATCCTCACAAATCATCTACGGTA AAGGCGGTGCTGCTCTTGTTAAAGTCATTTGTTGGGACAGGTGTGCTTTTCCTACCAAAG GCTTTCCATAACGGTGGTTGGGGATTTAGCGCCCTTTGTCTACTCTCGTGTGCCCTCATT TCTTATGGATGTTTCGTATCATTGATTACCACCAAGGACAAAGTAGGCGTAGATGGGTAC GGTGACATGGGTCGTATACTATATGGGCCCAAAATGAAATTTGCCATTCTTTCGTCTATC GCCTTGTCACAAATCGGGTTTTCTGCTGCATACACTGTTTTCACTGCAACTAATTTGCAG GTCTTTTCTGAAAATTTCTTCCATTTGAAACCGGGCAGCATCAGTCTAGCCACCTATATC TTTGCACAAGTACTCATCTTTGTCCCACTATCTTTGACAAGAAACATAGCCAAGTTAAGT GGGACCGCGTTAATAGCAGATCTATTTATTCTACTGGGATTGGTTTATGTTTACGTTTAC TCCATTTATTATATTGCTGTTAATGGTGTCGCATCCGATACAATGCTTATGTTCAATAAA GCGGACTGGTCGTTGTTCATCGGTACCGCCATATTCACCTTTGAAGGTATAGGCCTACTT ATCCCCATTCAGGAGTCAATGAAACACCCGAAGCATTTCCGGCCATCGTTGTCCGCGGTG ATGTGTATCGTGGCAGTGATTTTCATATCATGTGGTCTCTTATGCTATGCCGCTTTTGGA TCTGACGTGAAAACTGTTGTTTTATTGAATTTTCCGCAGGACACTTCCTATACTCTCACT GTTCAATTACTGTATGCATTAGCCATTTTGTTATCCACGCCGTTGCAGCTATTTCCCGCG ATACGTATTTTGGAAAACTGGACTTTTCCCTCAAATGCATCTGGTAAATACAACCCGAAA GTCAAATGGTTGAAAAACTATTTCCGTTGCGCTATTGTCGTCCTGACATCTATCCTCGCT TGGGTAGGCGCCAACGATTTGGACAAATTTGTATCACTGGTAGGCTCCTTCGCGTGTATC CCATTGATCTACATATACCCGCCATTGTTGCACTATAAGGCGTCCATCTTATCTGGAACC TCGAGAGCCAGGCTTCTTTTAGATTTAATCGTCATAGTATTTGGAGTTGCTGTCATGGCC TACACGTCATGGCAGACGATTAAAATGTGGAGCCAGTAA
Protein Properties
Pfam Domain Function
Protein Residues692
Protein Molecular Weight75458.70313
Protein Theoretical pI8.69
Signalling Regions
  • None
Transmembrane Regions
  • 302-322
  • 329-349
  • 374-394
  • 412-432
  • 443-463
  • 483-503
  • 519-539
  • 561-581
  • 607-627
  • 630-650
  • 665-685
Protein Sequence>Vacuolar amino acid transporter 3 MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSG TTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSN SLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASI ASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFF TRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTV KAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGY GDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYI FAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNK ADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFG SDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPK VKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGT SRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ
References
External Links
ResourceLink
Saccharomyces Genome Database AVT3
Uniprot IDP36062
Uniprot NameAVT3_YEAST
GenBank Gene IDZ28146
Genebank Protein ID486252
General Reference
  • Vandenbol, M., Bolle, P. A., Dion, C., Portetelle, D., Hilger, F. (1994). "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae." Yeast 10 Suppl A:S35-S40.8091859
  • Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
  • Russnak, R., Konczal, D., McIntire, S. L. (2001). "A family of yeast proteins mediating bidirectional vacuolar amino acid transport." J Biol Chem 276:23849-23857.11274162
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956