| Identification |
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| Name | Vacuolar amino acid transporter 3 |
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| Synonyms | Not Available |
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| Gene Name | AVT3 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Amino acid transport and metabolism |
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| Specific Function | Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine |
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| Cellular Location | Vacuole membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00002 | L-Glutamine | Show | | YMDB00038 | L-Isoleucine | Show | | YMDB00226 | L-Asparagine | Show | | YMDB00364 | L-Tyrosine | Show | | YMDB00387 | L-Leucine | Show | | YMDB00862 | hydron | Show |
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| GO Classification | Not Available |
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| Gene Properties |
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| Chromosome Location | chromosome 11 |
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| Locus | YKL146W |
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| Gene Sequence | >2079 bp
ATGAATGGAAAAGAGGTTTCAAGTGGCTCTGGAAGAACGCAGAGCAACAACAACAAAAAA
AATAACAACGGAGGCAGTACAGGAATCTCGCATGCGTCTGGCTCACCTTTAACGGACGGC
AACGGTGGCAATAGCAACGGTAATAGTAGAAGTAGAAGCAGAAGTAGAAAATCTAGTGGA
ACTACAGGTGGTTTGCTAAAAAAGCCGCCGCTGCTTGTGAACAATGAAGCGGTGCATGCT
AGCGTACCCGACGCGTCGCACACTTCCTGTAACAATGGCACGCTTGAAGTGAGCATAAAT
AACCCTGAGCCACATGTGGTAGATGCCGTGGCACGCCACTTGATAAGAAACCCGAGTAAC
AGCCTACAATTGCAAGGCGGAGACATTACAAGAGATCTGTATAAGTGGACAAACGACCAT
CCTTCATCACCATCGCAGTATCAGTACCCAAGTCAACCTGCACTTTCCACCTCAATACCT
TCACAAGCGCCCTCATTCTCGAATCGTAAAAGGTCTATGAGCTTTTCTGCCGCTTCTATA
GCATCTTCCTCTCACCTTAACAACAACTCGGAGGCGAATGGGAATCCTCTAGCGGCAATA
GGCCTGGCGCCCGCACCGATGACGCACGAAGAAATCAGGGCTCCTGGTGGATTCAGAAGA
TCTTTTATAATACAGAAGCGCAGGAAACATAACGTTGATGCGCCCATACCGAATTTTTTC
ACCAGGAACTTTATTGAATTTTTGACCTTGTATGGCCACTTCGCTGGTGAAGATTTATCG
GAAGAAGAGGAGGAGGAGGAAGAAACTGAAGAGGAGCCAGAGGAGGAAGCTTTGGAAACG
GAAAGCACCCAGCTAGTTTCTCGTGAACACGGGCGCCATCCTCACAAATCATCTACGGTA
AAGGCGGTGCTGCTCTTGTTAAAGTCATTTGTTGGGACAGGTGTGCTTTTCCTACCAAAG
GCTTTCCATAACGGTGGTTGGGGATTTAGCGCCCTTTGTCTACTCTCGTGTGCCCTCATT
TCTTATGGATGTTTCGTATCATTGATTACCACCAAGGACAAAGTAGGCGTAGATGGGTAC
GGTGACATGGGTCGTATACTATATGGGCCCAAAATGAAATTTGCCATTCTTTCGTCTATC
GCCTTGTCACAAATCGGGTTTTCTGCTGCATACACTGTTTTCACTGCAACTAATTTGCAG
GTCTTTTCTGAAAATTTCTTCCATTTGAAACCGGGCAGCATCAGTCTAGCCACCTATATC
TTTGCACAAGTACTCATCTTTGTCCCACTATCTTTGACAAGAAACATAGCCAAGTTAAGT
GGGACCGCGTTAATAGCAGATCTATTTATTCTACTGGGATTGGTTTATGTTTACGTTTAC
TCCATTTATTATATTGCTGTTAATGGTGTCGCATCCGATACAATGCTTATGTTCAATAAA
GCGGACTGGTCGTTGTTCATCGGTACCGCCATATTCACCTTTGAAGGTATAGGCCTACTT
ATCCCCATTCAGGAGTCAATGAAACACCCGAAGCATTTCCGGCCATCGTTGTCCGCGGTG
ATGTGTATCGTGGCAGTGATTTTCATATCATGTGGTCTCTTATGCTATGCCGCTTTTGGA
TCTGACGTGAAAACTGTTGTTTTATTGAATTTTCCGCAGGACACTTCCTATACTCTCACT
GTTCAATTACTGTATGCATTAGCCATTTTGTTATCCACGCCGTTGCAGCTATTTCCCGCG
ATACGTATTTTGGAAAACTGGACTTTTCCCTCAAATGCATCTGGTAAATACAACCCGAAA
GTCAAATGGTTGAAAAACTATTTCCGTTGCGCTATTGTCGTCCTGACATCTATCCTCGCT
TGGGTAGGCGCCAACGATTTGGACAAATTTGTATCACTGGTAGGCTCCTTCGCGTGTATC
CCATTGATCTACATATACCCGCCATTGTTGCACTATAAGGCGTCCATCTTATCTGGAACC
TCGAGAGCCAGGCTTCTTTTAGATTTAATCGTCATAGTATTTGGAGTTGCTGTCATGGCC
TACACGTCATGGCAGACGATTAAAATGTGGAGCCAGTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 692 |
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| Protein Molecular Weight | 75458.70313 |
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| Protein Theoretical pI | 8.69 |
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| Signalling Regions | |
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| Transmembrane Regions | - 302-322
- 329-349
- 374-394
- 412-432
- 443-463
- 483-503
- 519-539
- 561-581
- 607-627
- 630-650
- 665-685
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| Protein Sequence | >Vacuolar amino acid transporter 3
MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSG
TTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSN
SLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASI
ASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFF
TRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTV
KAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGY
GDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYI
FAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNK
ADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFG
SDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPK
VKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGT
SRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ |
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| References |
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| External Links | |
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| General Reference | - Vandenbol, M., Bolle, P. A., Dion, C., Portetelle, D., Hilger, F. (1994). "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae." Yeast 10 Suppl A:S35-S40.8091859
- Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
- Russnak, R., Konczal, D., McIntire, S. L. (2001). "A family of yeast proteins mediating bidirectional vacuolar amino acid transport." J Biol Chem 276:23849-23857.11274162
- Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
- Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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