| Identification |
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| Name | Carboxylic acid transporter protein homolog |
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| Synonyms | Not Available |
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| Gene Name | JEN1 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in carbohydrate transmembrane transporter activity |
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| Specific Function | Essential to lactate transport |
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| Cellular Location | Membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00175 | Pyruvic acid | Show | | YMDB00247 | L-Lactic acid | Show | | YMDB00287 | D-Lactic acid | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| intrinsic to membrane | | integral to membrane | | cell part | | membrane part | | Function |
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| transporter activity | | transmembrane transporter activity | | substrate-specific transmembrane transporter activity | | carbohydrate transmembrane transporter activity | | Process |
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| transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 11 |
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| Locus | YKL217W |
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| Gene Sequence | >1851 bp
ATGTCGTCGTCAATTACAGATGAGAAAATATCTGGTGAACAGCAACAACCTGCTGGCAGA
AAACTATACTATAACACAAGTACATTTGCAGAGCCTCCTCTAGTGGACGGAGAAGGTAAC
CCTATAAATTATGAGCCGGAAGTTTACAACCCGGATCACGAAAAGCTATACCATAACCCA
TCACTGCCTGCACAATCAATTCAGGATACAAGAGATGATGAATTGCTGGAAAGAGTTTAT
AGCCAGGATCAAGGTGTAGAGTATGAGGAAGATGAAGAGGATAAGCCAAACCTAAGCGCT
GCGTCCATTAAAAGTTATGCTTTAACGAGATTTACGTCCTTACTGCACATCCACGAGTTT
TCTTGGGAGAATGTCAATCCCATACCCGAACTGCGCAAAATGACATGGCAGAATTGGAAC
TATTTTTTTATGGGTTATTTTGCGTGGTTGTCTGCGGCTTGGGCCTTCTTTTGCGTTTCA
GTATCAGTCGCTCCATTGGCTGAACTATATGACAGACCAACCAAGGACATCACCTGGGGG
TTGGGATTGGTGTTATTTGTTCGTTCAGCAGGTGCTGTCATATTTGGTTTATGGACAGAT
AAGTCTTCCAGAAAGTGGCCGTACATTACATGTTTGTTCTTATTTGTCATTGCACAACTC
TGTACTCCATGGTGTGACACATACGAGAAATTTCTGGGCGTAAGGTGGATAACCGGTATT
GCTATGGGAGGAATTTACGGATGTGCTTCTGCAACAGCGATTGAAGATGCACCTGTGAAA
GCACGTTCGTTCCTATCAGGTCTATTTTTTTCTGCTTACGCTATGGGGTTCATATTTGCT
ATCATTTTTTACAGAGCCTTTGGCTACTTTAGGGATGATGGCTGGAAAATATTGTTTTGG
TTTAGTATTTTTCTACCAATTCTACTAATTTTCTGGAGATTGTTATGGCCTGAAACGAAA
TACTTCACCAAGGTTTTGAAAGCCCGTAAATTAATATTGAGTGACGCAGTGAAAGCTAAT
GGTGGCGAGCCTCTACCAAAAGCCAACTTTAAACAAAAGATGGTATCCATGAAGAGAACA
GTTCAAAAGTACTGGTTGTTGTTCGCATATTTGGTTGTTTTATTGGTGGGTCCAAATTAC
TTGACTCATGCTTCTCAAGACTTGTTGCCAACCATGCTGCGTGCCCAATTAGGCCTATCC
AAGGATGCTGTCACTGTCATTGTAGTGGTTACCAACATCGGTGCTATTTGTGGGGGTATG
ATATTTGGACAGTTCATGGAAGTTACTGGAAGAAGATTAGGCCTATTGATTGCATGCACA
ATGGGTGGTTGCTTCACCTACCCTGCATTTATGTTGAGAAGCGAAAAGGCTATATTAGGT
GCCGGTTTCATGTTATATTTTTGTGTCTTTGGTGTCTGGGGTATCCTGCCCATTCACCTT
GCAGAGTTGGCCCCTGCTGATGCAAGGGCTTTGGTTGCCGGTTTATCTTACCAGCTAGGT
AATCTAGCTTCTGCAGCGGCTTCCACGATTGAGACACAGTTAGCTGATAGATACCCATTA
GAAAGAGATGCCTCTGGTGCTGTGATTAAAGAAGATTATGCCAAAGTTATGGCTATCTTG
ACTGGTTCTGTTTTCATCTTCACATTTGCTTGTGTTTTTGTTGGCCATGAGAAATTCCAT
CGTGATTTGTCCTCTCCTGTTATGAAGAAATATATAAACCAAGTGGAAGAATACGAAGCC
GATGGTCTTTCGATTAGTGACATTGTTGAACAAAAGACGGAATGTGCTTCAGTGAAGATG
ATTGATTCGAACGTCTCAAAGACATATGAGGAGCATATTGAGACCGTTTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 616 |
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| Protein Molecular Weight | 69375.60156 |
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| Protein Theoretical pI | 5.72 |
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| Signalling Regions | |
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| Transmembrane Regions | - 141-161
- 177-197
- 206-226
- 231-251
- 264-284
- 297-317
- 364-384
- 403-423
- 433-453
- 458-478
- 490-510
- 536-556
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| Protein Sequence | >Carboxylic acid transporter protein homolog
MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNP
SLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEF
SWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWG
LGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGI
AMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFW
FSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRT
VQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGM
IFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHL
AELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAIL
TGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKM
IDSNVSKTYEEHIETV |
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| References |
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| External Links | |
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| General Reference | - Tzermia, M., Horaitis, O., Alexandraki, D. (1994). "The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein." Yeast 10:663-679.7941750
- Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
- Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
- Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666
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