Serine/threonine-protein kinase TOR1 (P35169)

Identification

Name

Serine/threonine-protein kinase TOR1

Synonyms

Dominant rapamycin resistance protein 1
Phosphatidylinositol kinase homolog TOR1
Target of rapamycin kinase 1

Gene Name

TOR1

Enzyme Class

Not Available

Biological Properties

General Function

translational initiation

Specific Function

Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:10995454, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372).

Cellular Location

Not Available

SMPDB Pathways

TOR signalling pathway: Rapamycin based repression

PW002514

KEGG Pathways

Not Available

SMPDB Reactions

Type 2A phosphatase activator TIP41 + phosphate → Phosphorylated TIP41

KEGG Reactions

Not Available

Metabolites

YMDB ID	Name	View
YMDB00907	phosphate	Show

GO Classification

Function
fungal-type cell wall organization
translational initiation
TOR signaling
protein kinase activity
regulation of cell cycle
extrinsic component of cytoplasmic side of plasma membrane
Golgi membrane
TORC1 complex
ATP binding
macromolecular complex binding
nucleus
cellular response to DNA damage stimulus
cytoplasm
meiotic nuclear division
protein serine/threonine kinase activity
mitochondria-nucleus signaling pathway
peptidyl-serine phosphorylation
negative regulation of autophagy
endosome membrane
regulation of cell growth
plasma membrane
regulation of sphingolipid biosynthetic process
fungal-type vacuole membrane
ribosome biogenesis
DNA repair
transcription of nuclear large rRNA transcript from RNA polymerase I promoter

Gene Properties

Chromosome Location

Not Available

Locus

Gene Sequence

>7413 bp ATGGAACCGCATGAGGAGCAGATTTGGAAGAGTAAACTTTTGAAAGCGGCTAACAACGAT ATGGACATGGATAGAAATGTGCCGTTGGCACCGAATCTGAATGTGAATATGAACATGAAA ATGAATGCGAGCAGGAACGGGGATGAATTCGGTCTGACTTCTAGTAGGTTTGATGGAGTG GTGATTGGCAGTAATGGGGATGTAAATTTTAAGCCCATTTTGGAGAAAATTTTCCGCGAA TTAACCAGTGATTACAAGGAGGAACGAAAATTGGCCAGTATTTCATTATTTGATCTACTA GTATCCTTGGAACATGAATTGTCGATAGAAGAGTTCCAAGCAGTTTCAAATGACATAAAC AATAAGATTTTGGAGCTGGTCCATACAAAAAAAACGAGCACTAGGGTAGGGGCTGTTCTA TCCATAGACACTTTGATTTCATTCTACGCATATACTGAAAGGTTGCCTAACGAAACTTCA CGACTGGCTGGTTACCTTCGAGGGCTAATACCTTCTAATGATGTAGAGGTCATGAGACTC GCTGCAAAGACTCTGGGCAAGTTAGCCGTTCCAGGAGGTACATATACCTCTGATTTCGTG GAATTTGAGATAAAGTCTTGCTTAGAATGGCTTACTGCCTCCACGGAAAAGAATTCATTC TCGAGTTCGAAGCCAGACCATGCTAAACATGCTGCGCTTCTGATTATAACAGCGTTGGCA GAGAATTGTCCTTATTTACTCTACCAATACTTGAATTCCATACTAGATAACATTTGGAGA GCACTAAGAGACCCACATTTGGTGATCAGAATTGATGCGTCCATTACATTGGCCAAATGT CTTTCCACCCTACGAAATAGGGATCCTCAGTTAACTAGCCAGTGGGTGCAGAGATTGGCT ACAAGTTGTGAATACGGATTTCAAGTAAACACATTAGAATGCATCCATGCAAGTTTGTTG GTTTATAAGGAAATCTTGTTTTTGAAGGATCCCTTTTTGAATCAAGTGTTCGACCAAATG TGTCTAAATTGCATAGCTTATGAAAATCATAAAGCGAAAATGATTAGAGAAAAGATTTAC CAGATTGTTCCCCTATTAGCATCGTTCAATCCTCAATTATTTGCTGGCAAATATTTGCAC CAAATTATGGACAACTATTTAGAGATTTTAACCAATGCTCCAGCAAATAAAATACCACAT CTCAAAGATGACAAACCACAGATTTTAATATCGATTGGTGATATTGCATATGAAGTCGGG CCCGATATCGCACCTTATGTGAAACAAATTCTTGATTATATTGAACATGATTTACAGACG AAATTCAAATTCAGAAAGAAATTTGAAAATGAAATTTTCTACTGCATCGGAAGATTGGCA GTTCCCTTGGGCCCCGTTCTAGGTAAATTATTAAACAGAAATATACTGGACCTGATGTTC AAATGCCCTCTTTCCGACTATATGCAGGAAACGTTTCAAATTCTGACTGAGAGAATACCA TCACTAGGCCCCAAAATAAATGACGAGTTGCTTAACCTAGTCTGTTCAACCTTATCTGGA ACACCATTTATCCAGCCAGGGTCACCAATGGAGATACCATCGTTTTCGAGAGAAAGAGCA AGAGAATGGAGAAATAAAAACATCCTACAGAAAACTGGTGAAAGTAACGATGATAATAAT GATATAAAAATCATTATACAAGCTTTTAGAATGTTAAAAAATATCAAAAGCAGATTTTCG TTGGTGGAATTCGTGAGAATTGTTGCACTTTCTTACATTGAGCATACAGATCCCAGAGTA AGGAAACTAGCTGCGTTGACATCTTGTGAAATTTACGTCAAGGATAACATCTGCAAACAA ACATCACTACACTCTCTGAACACTGTATCTGAAGTGTTATCAAAGCTTCTAGCCATTACG ATTGCGGACCCTTTACAAGATATCCGTTTAGAAGTTTTAAAGAATCTTAATCCATGTTTC GATCCCCAGTTGGCACAACCAGATAATTTGAGACTCTTGTTTACTGCACTGCACGATGAG TCGTTCAATATTCAGTCAGTAGCAATGGAGCTTGTCGGTAGGTTGTCTTCCGTAAACCCT GCATACGTCATCCCATCGATAAGAAAAATACTACTGGAACTGCTAACAAAATTAAAATTC TCAACTTCTTCTCGAGAAAAGGAAGAAACTGCCAGTTTGTTATGTACTCTTATCAGGTCG AGTAAAGATGTTGCGAAACCTTATATCGAACCTCTTTTAAATGTTCTTTTACCAAAATTC CAAGATACCTCTTCAACGGTTGCATCAACTGCACTGAGAACTATAGGTGAGCTATCTGTT GTAGGGGGCGAAGATATGAAGATATATCTTAAGGATTTGTTTCCTTTAATTATCAAAACA TTTCAGGATCAATCAAACTCTTTCAAGAGAGAAGCTGCACTTAAGGCCCTTGGTCAACTT GCAGCCTCATCTGGTTACGTGATAGATCCTTTACTCGACTATCCCGAATTATTGGGTATA TTGGTGAATATATTGAAGACAGAAAACTCTCAAAATATTAGGAGACAAACAGTCACTTTG ATAGGTATACTGGGAGCTATCGACCCATATCGCCAAAAAGAACGTGAGGTTACCTCTACT ACCGATATATCTACAGAACAGAACGCCCCGCCTATCGACATTGCTCTTCTCATGCAGGGC ATGTCTCCTTCGAATGATGAGTATTATACCACTGTTGTCATTCACTGCCTGCTAAAAATC CTAAAAGATCCATCCCTATCATCTTACCACACTGCCGTGATCCAAGCGATTATGCATATT TTTCAAACCCTTGGTCTAAAATGTGTTTCATTCTTGGACCAGATCATCCCAACTATTTTG GACGTAATGCGTACATGCTCTCAGTCACTATTAGAATTTTACTTCCAACAGCTTTGCTCT TTGATTATTATCGTAAGGCAACACATAAGACCTCATGTCGATTCTATATTCCAGGCTATC AAAGATTTTTCTTCGGTTGCTAAGCTACAAATAACGCTTGTAAGTGTTATTGAAGCAATA TCAAAGGCTCTGGAGGGTGAATTCAAAAGATTGGTCCCTCTTACTCTGACCTTGTTCCTT GTAATTTTGGAGAATGACAAGTCTAGTGACAAGGTCCTCTCCAGAAGGGTATTGAGACTG TTAGAATCGTTTGGTCCTAACTTAGAAGGTTATTCGCATTTGATTACACCCAAGATAGTT CAAATGGCAGAATTCACCAGCGGGAACCTACAAAGGTCTGCAATAATTACTATTGGCAAA CTGGCCAAGGATGTTGACCTTTTTGAGATGTCCTCAAGAATTGTTCACTCTTTACTTAGG GTACTAAGTTCAACAACGAGTGACGAACTCTCAAAAGTCATTATGAATACTTTAAGTCTA CTGCTAATACAAATGGGCACATCCTTTGCTATCTTCATCCCTGTCATTAATGAAGTTTTA ATGAAGAAACATATTCAACACACAATATATGATGACTTGACAAACAGAATATTAAACAAT GATGTTTTACCCACAAAAATTCTTGAAGCAAATACAACGGATTATAAGCCCGCGGAACAA ATGGAGGCAGCAGATGCTGGGGTCGCAAAATTACCTATAAACCAATCAGTTTTGAAAAGT GCATGGAATTCTAGCCAACAAAGAACTAAAGAAGATTGGCAGGAATGGAGCAAACGTCTA TCCATTCAATTATTAAAAGAGTCACCCTCCCATGCTCTAAGAGCTTGTTCAAATCTTGCA AGCATGTATTATCCACTAGCCAAAGAACTTTTTAATACCGCATTCGCATGTGTTTGGACC GAACTTTATAGCCAATATCAAGAAGATTTAATTGGGTCATTATGTATAGCCTTATCTTCT CCCTTAAATCCACCAGAAATACATCAAACATTGTTAAACCTGGTAGAATTTATGGAACAC GATGACAAGGCATTACCAATACCAACTCAAAGCCTGGGCGAGTATGCTGAAAGATGTCAC GCCTATGCCAAAGCGCTACATTATAAAGAGATTAAATTTATTAAAGAGCCTGAGAACTCA ACTATTGAATCATTGATCAGCATTAACAACCAGCTGAATCAAACGGATGCTGCAATTGGT ATATTAAAGCATGCCCAACAACATCATTCACTTCAATTAAAGGAGACATGGTTTGAAAAA TTAGAGCGTTGGGAAGATGCACTACATGCTTATAATGAACGTGAAAAGGCAGGTGATACT TCCGTGAGCGTTACACTCGGTAAGATGAGATCCCTTCATGCCCTTGGCGAATGGGAACAG TTGTCGCAATTGGCAGCTAGAAAGTGGAAAGTTTCGAAGCTACAAACTAAGAAGCTAATA GCTCCCTTGGCAGCTGGTGCTGCGTGGGGGTTGGGAGAGTGGGATATGCTTGAGCAATAT ATCAGCGTTATGAAACCTAAATCTCCAGATAAGGAATTTTTTGATGCAATTTTATACTTG CACAAGAATGATTACGACAATGCTAGTAAGCATATATTAAACGCCAGAGATTTGCTTGTG ACTGAAATTTCCGCGTTGATCAATGAAAGTTATAATAGAGCATATAGCGTTATTGTTAGA ACTCAAATAATAACAGAGTTTGAGGAAATCATCAAGTATAAACAATTGCCACCTAATTCC GAGAAAAAACTTCACTATCAAAATCTTTGGACAAAAAGACTGCTGGGCTGCCAAAAAAAT GTCGATTTATGGCAAAGAGTGCTTAGAGTAAGATCATTGGTAATAAAGCCCAAGCAAGAC CTGCAAATATGGATAAAATTTGCAAATTTGTGCAGAAAATCTGGTAGAATGAGGCTAGCA AATAAGGCATTGAATATGCTACTAGAAGGAGGCAACGATCCTAGTTTACCAAATACGTTC AAAGCTCCTCCCCCAGTTGTTTACGCGCAACTAAAATATATTTGGGCTACAGGAGCTTAT AAAGAAGCATTAAACCACTTGATAGGATTTACATCCAGGTTAGCGCATGATCTTGGTTTG GATCCGAATAATATGATCGCGCAAAGTGTCAAACTCTCAAGTGCAAGTACTGCTCCGTAT GTTGAGGAATACACAAAATTATTAGCTCGATGTTTTTTAAAGCAAGGTGAGTGGAGAATA GCAACACAACCGAACTGGAGAAACACAAATCCGGATGCAATTCTTGGTTCTTATCTATTG GCTACACATTTCGATAAAAATTGGTACAAGGCATGGCATAATTGGGCCTTAGCTAATTTT GAAGTAATATCCATGGTTCAGGAAGAGACTAAGCTCAACGGAGGTAAGAATGATGATGAT GATGACACGGCAGTTAATAATGATAATGTGCGGATTGACGGTAGTATCCTAGGAAGTGGT TCTTTGACTATTAATGGCAACAGATACCCGCTAGAGCTTATTCAAAGACATGTTGTTCCA GCGATCAAGGGCTTTTTTCATTCAATATCTCTATTAGAAACAAGTTGTTTGCAAGACACG TTGAGGTTATTGACTCTTTTATTTAACTTTGGTGGTATTAAAGAAGTCTCACAAGCCATG TATGAAGGCTTCAATTTGATGAAAATAGAGAACTGGCTTGAAGTCTTACCACAGTTGATC TCTCGTATACATCAGCCAGATCCTACGGTGAGTAATTCCCTTTTGTCGTTGCTTTCTGAT TTAGGGAAAGCTCATCCACAAGCTCTCGTGTATCCTTTAACTGTCGCGATCAAGTCTGAA TCTGTTTCAAGACAAAAAGCGGCTCTTTCAATAATAGAGAAAATTAGGATTCATAGTCCA GTCCTGGTAAACCAGGCAGAATTAGTTAGTCACGAGTTGATCAGAGTAGCCGTTCTATGG CACGAATTATGGTATGAAGGACTGGAAGATGCGAGCCGCCAATTTTTCGTTGAACATAAC ATAGAAAAAATGTTTTCTACTTTAGAACCTTTACATAAACACTTAGGCAATGAGCCTCAA ACGTTAAGTGAGGTATCGTTTCAGAAATCATTTGGTAGAGATTTGAACGATGCCTACGAA TGGTTGAATAACTACAAAAAGTCAAAAGACATCAATAATTTGAACCAAGCTTGGGATATT TATTATAACGTCTTCAGAAAAATAACACGTCAAATACCACAGTTACAAACCTTAGACTTA CAGCATGTTTCTCCCCAGCTTCTGGCTACTCATGATCTCGAATTGGCTGTTCCTGGGACA TATTTCCCAGGAAAACCTACCATTAGAATAGCGAAGTTTGAGCCATTATTTTCTGTGATC TCTTCGAAGCAAAGGCCAAGAAAATTCTCCATCAAGGGTAGCGACGGTAAAGATTATAAA TACGTTTTAAAGGGACATGAAGATATAAGACAAGATAGCCTTGTTATGCAATTATTTGGT CTAGTTAACACTTTGTTGAAGAATGATTCAGAGTGTTTCAAGAGACATTTGGATATCCAA CAATACCCGGCTATTCCATTGTCGCCTAAATCTGGTTTACTAGGATGGGTACCAAATAGT GACACATTCCACGTTTTGATCAGAGAACACCGTGATGCCAAAAAAATTCCGTTGAACATT GAACATTGGGTTATGTTACAAATGGCCCCCGATTATGAGAATTTGACTCTTTTACAAAAA ATTGAAGTATTCACGTACGCTTTAGATAATACAAAAGGCCAAGACCTTTATAAAATATTA TGGTTAAAGAGTAGGTCGTCAGAGACATGGCTAGAACGTAGAACAACTTATACGAGATCT TTAGCAGTTATGTCCATGACTGGTTATATTCTGGGACTAGGTGATCGCCATCCAAGCAAC CTGATGCTAGATAGAATCACCGGTAAAGTTATCCACATTGATTTCGGCGATTGTTTTGAA GCTGCCATCTTAAGAGAAAAGTATCCAGAAAAAGTGCCATTTAGACTAACTAGGATGTTA ACATACGCAATGGAAGTTAGTGGAATTGAAGGCAGTTTCCGAATTACTTGTGAAAATGTC ATGAGAGTCTTAAGAGATAATAAAGAATCATTAATGGCGATCTTGGAAGCTTTTGCGCTT GATCCTTTGATCCATTGGGGATTTGATTTACCGCCACAAAAACTTACTGAGCAAACTGGA ATTCCTTTGCCGTTGATTAATCCTAGTGAATTATTAAGGAAGGGGGCAATTACTGTCGAA GAAGCGGCAAATATGGAAGCAGAACAACAAAATGAGACCAAAAACGCCAGAGCAATGCTT GTTTTGAGACGTATTACAGATAAATTAACGGGCAATGATATCAAGAGGTTCAATGAATTA GACGTCCCTGAGCAGGTTGATAAACTGATCCAACAAGCCACTTCTATTGAAAGGTTATGT CAACATTATATTGGATGGTGCCCATTCTGGTGA

Protein Properties

Pfam Domain Function

Not Available

Protein Residues

2470

Protein Molecular Weight

281136.755

Protein Theoretical pI

Not Available

PDB File

show

Signalling Regions

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein kinase TOR1 MEPHEEQIWKSKLLKAANNDMDMDRNVPLAPNLNVNMNMKMNASRNGDEFGLTSSRFDGV VIGSNGDVNFKPILEKIFRELTSDYKEERKLASISLFDLLVSLEHELSIEEFQAVSNDIN NKILELVHTKKTSTRVGAVLSIDTLISFYAYTERLPNETSRLAGYLRGLIPSNDVEVMRL AAKTLGKLAVPGGTYTSDFVEFEIKSCLEWLTASTEKNSFSSSKPDHAKHAALLIITALA ENCPYLLYQYLNSILDNIWRALRDPHLVIRIDASITLAKCLSTLRNRDPQLTSQWVQRLA TSCEYGFQVNTLECIHASLLVYKEILFLKDPFLNQVFDQMCLNCIAYENHKAKMIREKIY QIVPLLASFNPQLFAGKYLHQIMDNYLEILTNAPANKIPHLKDDKPQILISIGDIAYEVG PDIAPYVKQILDYIEHDLQTKFKFRKKFENEIFYCIGRLAVPLGPVLGKLLNRNILDLMF KCPLSDYMQETFQILTERIPSLGPKINDELLNLVCSTLSGTPFIQPGSPMEIPSFSRERA REWRNKNILQKTGESNDDNNDIKIIIQAFRMLKNIKSRFSLVEFVRIVALSYIEHTDPRV RKLAALTSCEIYVKDNICKQTSLHSLNTVSEVLSKLLAITIADPLQDIRLEVLKNLNPCF DPQLAQPDNLRLLFTALHDESFNIQSVAMELVGRLSSVNPAYVIPSIRKILLELLTKLKF STSSREKEETASLLCTLIRSSKDVAKPYIEPLLNVLLPKFQDTSSTVASTALRTIGELSV VGGEDMKIYLKDLFPLIIKTFQDQSNSFKREAALKALGQLAASSGYVIDPLLDYPELLGI LVNILKTENSQNIRRQTVTLIGILGAIDPYRQKEREVTSTTDISTEQNAPPIDIALLMQG MSPSNDEYYTTVVIHCLLKILKDPSLSSYHTAVIQAIMHIFQTLGLKCVSFLDQIIPTIL DVMRTCSQSLLEFYFQQLCSLIIIVRQHIRPHVDSIFQAIKDFSSVAKLQITLVSVIEAI SKALEGEFKRLVPLTLTLFLVILENDKSSDKVLSRRVLRLLESFGPNLEGYSHLITPKIV QMAEFTSGNLQRSAIITIGKLAKDVDLFEMSSRIVHSLLRVLSSTTSDELSKVIMNTLSL LLIQMGTSFAIFIPVINEVLMKKHIQHTIYDDLTNRILNNDVLPTKILEANTTDYKPAEQ MEAADAGVAKLPINQSVLKSAWNSSQQRTKEDWQEWSKRLSIQLLKESPSHALRACSNLA SMYYPLAKELFNTAFACVWTELYSQYQEDLIGSLCIALSSPLNPPEIHQTLLNLVEFMEH DDKALPIPTQSLGEYAERCHAYAKALHYKEIKFIKEPENSTIESLISINNQLNQTDAAIG ILKHAQQHHSLQLKETWFEKLERWEDALHAYNEREKAGDTSVSVTLGKMRSLHALGEWEQ LSQLAARKWKVSKLQTKKLIAPLAAGAAWGLGEWDMLEQYISVMKPKSPDKEFFDAILYL HKNDYDNASKHILNARDLLVTEISALINESYNRAYSVIVRTQIITEFEEIIKYKQLPPNS EKKLHYQNLWTKRLLGCQKNVDLWQRVLRVRSLVIKPKQDLQIWIKFANLCRKSGRMRLA NKALNMLLEGGNDPSLPNTFKAPPPVVYAQLKYIWATGAYKEALNHLIGFTSRLAHDLGL DPNNMIAQSVKLSSASTAPYVEEYTKLLARCFLKQGEWRIATQPNWRNTNPDAILGSYLL ATHFDKNWYKAWHNWALANFEVISMVQEETKLNGGKNDDDDDTAVNNDNVRIDGSILGSG SLTINGNRYPLELIQRHVVPAIKGFFHSISLLETSCLQDTLRLLTLLFNFGGIKEVSQAM YEGFNLMKIENWLEVLPQLISRIHQPDPTVSNSLLSLLSDLGKAHPQALVYPLTVAIKSE SVSRQKAALSIIEKIRIHSPVLVNQAELVSHELIRVAVLWHELWYEGLEDASRQFFVEHN IEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDLNDAYEWLNNYKKSKDINNLNQAWDI YYNVFRKITRQIPQLQTLDLQHVSPQLLATHDLELAVPGTYFPGKPTIRIAKFEPLFSVI SSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQ QYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQMAPDYENLTLLQK IEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSN LMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENV MRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLTEQTGIPLPLINPSELLRKGAITVE EAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELDVPEQVDKLIQQATSIERLC QHYIGWCPFW

References

External Links

Resource	Link
Saccharomyces Genome Database	TOR1
Uniprot ID	P35169
Uniprot Name	TOR1
PDB ID
1W1N

General Reference

Not Available