Mitosis inhibitor protein kinase SWE1 (P32944)
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| Name | Mitosis inhibitor protein kinase SWE1 | ||||||||||||||||||
| Synonyms |
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| Gene Name | SWE1 | ||||||||||||||||||
| Enzyme Class | Not Available | ||||||||||||||||||
| Biological Properties | |||||||||||||||||||
| General Function | regulation of meiotic nuclear division | ||||||||||||||||||
| Specific Function | Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-19'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Inhibits the activity of B-type cyclins in replication initiation strongly for CLB2, moderately for CLB3 and CLB4, and there is no apparent inhibition for CLB5 and CLB6, correlating with the normal expression timing of those cyclins. Hyperphosphorylation and degradation of SWE1 when all checkpoint requirement are met releases CLB2-CDC28 from inhibition and allows for progression through the cell cycle. SWE1-dependent CDC28 phosphorylation is also required for pachytene arrest upon activation of the recombination checkpoint during meiosis. Also involved in the regulation of nitrogen starvation- and short chain alcohol-induced filamentous growth, or filamentous differentiation in response to slowed DNA synthesis. Can act both on serines and on tyrosines. | ||||||||||||||||||
| Cellular Location | Not Available | ||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | ||||||||||||||||||
| SMPDB Reactions | Not Available | ||||||||||||||||||
| KEGG Reactions | Not Available | ||||||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | |||||||||||||||||||
| Chromosome Location | Not Available | ||||||||||||||||||
| Locus | |||||||||||||||||||
| Gene Sequence | >2460 bp ATGAGTTCTTTGGACGAGGATGAAGAGGACTTCGAAATGCTGGACACGGAGAACCTCCAG TTTATGGGGAAGAAGATGTTTGGCAAACAGGCCGGCGAAGACGAGAGTGATGATTTTGCT ATAGGGGGTAGCACCCCGACCAATAAACTGAAATTTTATCCATATTCGAACAACAAATTG ACAAGAAGTACGGGGACCTTGAACCTGTCATTAAGTAATACAGCTTTGTCAGAGGCTAAC TCCAAATTTCTTGGGAAAATTGAAGAAGAGGAAGAAGAGGAGGAAGAAGGCAAGGATGAG GAAAGCGTGGATTCTCGTATTAAAAGGTGGTCTCCGTTCCATGAAAATGAAAGTGTTACT ACTCCTATTACAAAAAGATCTGCGGAAAAAACGAACAGTCCTATTTCTCTCAAACAATGG AACCAGCGATGGTTTCCGAAAAATGATGCTCGCACTGAAAATACATCCTCATCCTCTTCA TATAGCGTCGCTAAACCTAACCAATCAGCCTTTACGTCTTCGGGCCTCGTATCTAAAATG TCTATGGACACTTCGTTATACCCTGCGAAATTGAGGATACCAGAAACACCAGTGAAAAAA TCACCCTTAGTGGAGGGAAGAGACCATAAGCATGTCCACCTTTCGAGTTCGAAAAATGCA TCGTCTTCTCTAAGTGTTTCCCCTTTAAATTTTGTTGAAGACAATAATTTACAAGAAGAC CTTTTATTTTCAGATTCTCCGTCTTCGAAAGCTTTACCTTCCATCCATGTACCAACCATA GACTCATCCCCACTGAGCGAGGCAAAATATCATGCACATGATCGTCACAATAACCAGACA AACATCCTGTCTCCCACTAATAGCTTGGTTACCAACAGCTCTCCACAAACATTGCATTCT AACAAGTTCAAAAAAATCAAAAGAGCAAGGAATTCGGTTATTTTGAAAAATAGAGAGCTA ACAAACAGTTTACAACAATTCAAAGATGATTTATACGGCACGGACGAGAATTTCCCACCT CCAATCATAATATCAAGTCATCATTCAACTAGAAAGAACCCTCAACCTTATCAATTTCGT GGACGCTATGACAATGACACTGACGAAGAGATCTCCACTCCAACAAGACGAAAATCTATT ATTGGGGCAACATCTCAAACACATAGAGAAAGCAGACCATTGTCACTCTCCTCTGCCATC GTGACAAACACAACAAGTGCAGAGACGCATTCCATATCTTCCACCGATTCTTCGCCGTTA AATTCCAAAAGGCGTCTAATCTCTTCAAATAAGTTATCAGCAAATCCAGATTCCCATCTT TTCGAAAAATTTACGAATGTGCATTCCATTGGTAAAGGCCAGTTTTCCACGGTCTACCAG GTTACGTTTGCCCAAACAAACAAAAAGTATGCAATCAAAGCCATTAAACCAAACAAATAT AATTCCTTGAAACGCATATTACTGGAAATTAAAATACTAAACGAGGTAACAAACCAAATT ACAATGGATCAAGAAGGGAAGGAATACATCATCGATTACATCAGTTCCTGGAAGTTTCAA AATTCATACTATATTATGACAGAATTGTGCGAAAATGGTAATTTGGATGGATTTTTACAA GAGCAAGTTATCGCAAAGAAAAAAAGGTTGGAAGATTGGAGAATTTGGAAAATCATCGTG GAATTAAGCCTGGCTTTACGATTCATCCATGATTCTTGTCACATTGTGCATCTGGACTTG AAACCCGCAAACGTCATGATCACATTTGAAGGTAACCTAAAACTAGGTGACTTTGGAATG GCTACTCATTTACCGTTGGAGGATAAAAGTTTTGAAAATGAAGGTGACAGAGAATATATT GCACCAGAAATCATTTCTGATTGTACGTACGATTACAAGGCAGATATTTTTTCCCTGGGT CTGATGATTGTTGAAATTGCAGCGAACGTTGTGTTACCTGACAATGGCAACGCATGGCAT AAGTTGAGATCGGGTGATTTATCGGATGCAGGAAGATTAAGTTCCACAGATATTCATTCT GAATCATTATTTTCAGACATTACGAAAGTAGATACAAATGATTTATTTGATTTTGAAAGA GACAATATCAGTGGTAATAGTAACAACGCTGGCACCTCCACTGTTCATAACAATAGTAAT ATCAACAACCCTAATATGAATAATGGCAACGATAATAATAATGTCAATACTGCCGCTACC AAGAATCGTCTTATTTTGCATAAAAGTTCTAAAATTCCCGCATGGGTACCGAAATTTCTT ATTGATGGTGAATCACTTGAGAGAATAGTACGATGGATGATAGAGCCCAATTATGAGAGA AGGCCCACGGCAAATCAAATCTTACAAACTGAGGAATGCCTGTATGTAGAAATGACACGC AATGCAGGTGCTATTATCCAGGAAGACGACTTTGGACCTAAGCCAAAATTTTTTATATGA | ||||||||||||||||||
| Protein Properties | |||||||||||||||||||
| Pfam Domain Function | Not Available | ||||||||||||||||||
| Protein Residues | 819 | ||||||||||||||||||
| Protein Molecular Weight | 92467.12 | ||||||||||||||||||
| Protein Theoretical pI | Not Available | ||||||||||||||||||
| Signalling Regions | Not Available | ||||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||||
| Protein Sequence | >Mitosis inhibitor protein kinase SWE1 MSSLDEDEEDFEMLDTENLQFMGKKMFGKQAGEDESDDFAIGGSTPTNKLKFYPYSNNKL TRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKDEESVDSRIKRWSPFHENESVT TPITKRSAEKTNSPISLKQWNQRWFPKNDARTENTSSSSSYSVAKPNQSAFTSSGLVSKM SMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHLSSSKNASSSLSVSPLNFVEDNNLQED LLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTNSLVTNSSPQTLHS NKFKKIKRARNSVILKNRELTNSLQQFKDDLYGTDENFPPPIIISSHHSTRKNPQPYQFR GRYDNDTDEEISTPTRRKSIIGATSQTHRESRPLSLSSAIVTNTTSAETHSISSTDSSPL NSKRRLISSNKLSANPDSHLFEKFTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKY NSLKRILLEIKILNEVTNQITMDQEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQ EQVIAKKKRLEDWRIWKIIVELSLALRFIHDSCHIVHLDLKPANVMITFEGNLKLGDFGM ATHLPLEDKSFENEGDREYIAPEIISDCTYDYKADIFSLGLMIVEIAANVVLPDNGNAWH KLRSGDLSDAGRLSSTDIHSESLFSDITKVDTNDLFDFERDNISGNSNNAGTSTVHNNSN INNPNMNNGNDNNNVNTAATKNRLILHKSSKIPAWVPKFLIDGESLERIVRWMIEPNYER RPTANQILQTEECLYVEMTRNAGAIIQEDDFGPKPKFFI | ||||||||||||||||||
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| General Reference | Not Available | ||||||||||||||||||