| Identification |
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| Name | GABA-specific permease |
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| Synonyms | - GABA-specific transport protein
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| Gene Name | UGA4 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transport |
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| Specific Function | Required for high-affinity, high-specificity GABA transport. Also transports putrescine |
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| Cellular Location | Vacuole membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00083 | 5-Aminolevulinic acid | Show | | YMDB00335 | gamma-Aminobutyric acid | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| cell part | | membrane | | membrane part | | intrinsic to membrane | | integral to membrane | | Function |
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| amine transmembrane transporter activity | | amino acid transmembrane transporter activity | | transporter activity | | transmembrane transporter activity | | active transmembrane transporter activity | | Process |
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| amine transport | | amino acid transport | | transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 4 |
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| Locus | YDL210W |
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| Gene Sequence | >1716 bp
ATGAGTATGTCAAGCAAAAACGAGAATAAGATATCAGTAGAACAAAGAATATCCACTGAT
ATCGGTCAGGCTTACCAGTTACAAGGCCTTGGGTCTAACCTAAGGTCGATTCGCTCCAAG
ACTGGTGCCGGTGAAGTGAACTATATCGATGCTGCTAAATCTGTAAATGATAACCAACTG
CTTGCAGAGATCGGTTATAAACAAGAATTAAAAAGACAATTTTCAACATTACAAGTTTTC
GGTATTGCGTTCTCCATTATGGGTCTATTGCCCTCCATTGCATCTGTGATGGGTGGTGGG
CTCGGTGGTGGTCCAGCAACATTAGTGTGGGGTTGGTTCGTTGCTGCGTTTTTCATTTTA
CTGGTGGGTATTACCATGGCTGAACATGCAAGTTCCATTCCTACCGCTGGTGGTTTGTAC
TACTGGACGTATTACTATGCTCCAGAAGGTTATAAAGAGATTATTTCTTTTATTATTGGT
TGCTCAAACTCCCTAGCGTTGGCAGCCGGTGTGTGTTCCATTGATTACGGTTTGGCTGAG
GAAATTGCTGCTGCTGTCACATTAACCAAAGATGGAAATTTTGAAGTAACGAGTGGGAAA
CTTTACGGTATATTTGCTGGAGCAGTGGTGGTTATGTGTATTTGTACATGTGTTGCTTCT
GGGGCCATTGCTCGTCTGCAGACGCTAAGTATATTTGCCAATCTTTTCATTATTGTTTTA
TTGTTCATTGCGCTACCGATTGGTACCAAGCATAGAATGGGAGGTTTCAATGATGGTGAC
TTTATATTTGGGAAATATGAAAACTTAAGTGACTGGAATAATGGTTGGCAATTTTGTCTT
GCTGGTTTCATGCCTGCTGTCTGGACTATTGGTTCCTTTGATTCATGTGTCCATCAATCT
GAAGAAGCCAAAGATGCCAAGAAATCAGTCCCCATTGGTATAATCTCATCTATTGCTGTT
TGTTGGATTTTAGGTTGGTTGATTATTATTTGTTTAATGGCCTGTATCAACCCTGATATT
GACAGCGTTTTGGACTCCAAGTACGGCTTTGCTTTGGCTCAAATAATTTATGATTCGTTA
GGAAAAAAATGGGCCATTGCATTTATGTCATTGATCGCATTCTGTCAATTTCTAATGGGT
GCTTCCATTACCACAGCTGTTTCTAGACAAGTTTGGGCATTTTCCCGTGATAACGGTTTG
CCCCTATCAAAGTATATTAAAAGAGTGGATTCTAAATACTCGGTCCCTTTTTTCGCTATT
TTGGCTGCCTGTGTAGGTTCCTTGATTTTAGGATTGTTATGTTTGATTGATGATGCCGCC
ACTGATGCATTATTTAGTCTGGCTGTTGCAGGAAACAATTTGGCATGGAGTACCCCTACA
GTTTTCCGTTTAACATCAGGTAGAGATTTATTTAGACCTGGTCCATTTTATTTGGGTAAA
ATCTGGTCTCCAATTGTTGCTTGGACAGGTGTTGCTTTCCAATTGTTCATTATTATTTTG
GTTATGTTCCCCTCTCAACAACATGGTATTACTAAATCCACAATGAATTATGCATGCGTT
ATTGGTCCCGGTATCTGGATCCTTGCAGGTATCTACTACAAAGTTTACAAGAAGAAATAC
TACCACGGTCCAGCAACCAATTTGTCGGATGATGATTATACTGAAGCCGTTGGTGCTGAT
GTTATCGACACAATTATGTCCAAACAGGAACCATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 571 |
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| Protein Molecular Weight | 61872.30078 |
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| Protein Theoretical pI | 6.64 |
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| Signalling Regions | |
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| Transmembrane Regions | - 74-94
- 106-126
- 154-174
- 199-219
- 229-249
- 272-292
- 313-333
- 365-385
- 417-437
- 442-462
- 483-503
- 515-535
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| Protein Sequence | >GABA-specific permease
MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQL
LAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFIL
LVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAE
EIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVL
LFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQS
EEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSL
GKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAI
LAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGK
IWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKY
YHGPATNLSDDDYTEAVGADVIDTIMSKQEP |
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| References |
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| External Links | |
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| General Reference | - Andre, B., Hein, C., Grenson, M., Jauniaux, J. C. (1993). "Cloning and expression of the UGA4 gene coding for the inducible GABA-specific transport protein of Saccharomyces cerevisiae." Mol Gen Genet 237:17-25.8455553
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- Uemura, T., Tomonari, Y., Kashiwagi, K., Igarashi, K. (2004). "Uptake of GABA and putrescine by UGA4 on the vacuolar membrane in Saccharomyces cerevisiae." Biochem Biophys Res Commun 315:1082-1087.14985124
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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