Phosphatidic acid phosphohydrolase 1 (P32567)

Identification

Name

Phosphatidic acid phosphohydrolase 1

Synonyms

PAP1
Protein SMP2

Gene Name

PAH1

Enzyme Class

Not Available

Biological Properties

General Function

vacuole fusion, non-autophagic

Specific Function

Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controles transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.

Cellular Location

Not Available

SMPDB Pathways

Glycerophospholipid metabolism	PW002493
Triacylglycerol metabolism	PW002695
Triacylglycerol metabolism TG(10:0/10:0/10:0)	PW007514
Triacylglycerol metabolism TG(10:0/10:0/12:0)	PW007575
Triacylglycerol metabolism TG(10:0/10:0/14:0)	PW007576

KEGG Pathways

Glycerophospholipid metabolism

ec00564

SMPDB Reactions

PA(16:0/16:0) + water → DG(16:0/16:0/0:0) + phosphate

PA(10:0/10:0) + water → DG(10:0/10:0/0:0) + phosphate

PA(10:0/12:0) + water → DG(10:0/12:0/0:0) + phosphate

PA(10:0/14:0) + water → DG(10:0/14:0/0:0) + phosphate

PA(10:0/14:1(9Z)) + water → DG(10:0/14:1(9Z)/0:0) + phosphate

KEGG Reactions

Not Available

Metabolites

YMDB ID	Name	View
YMDB00890	water	Show
YMDB00907	phosphate	Show
YMDB01127	DG(16:0/16:0/0:0)	Show
YMDB01161	PA(16:0/16:0)	Show
YMDB12737	DG(14:0/14:0/0:0)	Show

GO Classification

Function
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
nuclear membrane
lipid particle
extrinsic component of membrane
vacuole
phosphatidate phosphatase activity
transcription coactivator activity
transcription regulatory region DNA binding
aerobic respiration
fatty acid catabolic process
lipid particle organization
phospholipid biosynthetic process
plasmid maintenance
endoplasmic reticulum membrane
triglyceride biosynthetic process
cytosol
vacuole fusion, non-autophagic

Gene Properties

Chromosome Location

Not Available

Locus

Gene Sequence

>2589 bp ATGCAGTACGTAGGCAGAGCTCTTGGGTCTGTGTCTAAAACATGGTCTTCTATCAATCCG GCTACGCTATCAGGTGCTATAGATGTCATTGTAGTGGAGCATCCAGACGGAAGGCTATCA TGTTCTCCCTTTCATGTGAGGTTCGGCAAATTTCAAATTCTAAAGCCATCTCAAAAGAAA GTCCAAGTGTTTATAAATGAGAAACTGAGTAATATGCCAATGAAACTGAGTGATTCTGGA GAAGCCTATTTCGTTTTCGAGATGGGTGACCAGGTCACTGATGTCCCTGACGAATTGCTT GTGTCGCCCGTGATGAGCGCCACATCAAGCCCCCCTCAATCACCTGAAACATCCATCTTA GAAGGAGGAACCGAGGGTGAAGGTGAAGGTGAAAATGAAAATAAGAAGAAGGAAAAGAAA GTGCTAGAGGAACCAGATTTTTTAGATATCAATGACACTGGAGATTCAGGCAGTAAAAAT AGTGAAACTACAGGGTCGCTTTCTCCTACTGAATCCTCTACAACGACACCACCAGATTCA GTTGAAGAGAGGAAGCTTGTTGAGCAGCGTACAAAGAACTTTCAGCAAAAACTAAACAAA AAACTCACTGAAATCCATATACCCAGTAAACTTGATAACAATGGCGACTTACTACTAGAC ACTGAAGGTTACAAGCCAAACAAGAATATGATGCATGACACAGACATACAACTGAAGCAG TTGTTAAAGGACGAATTCGGTAATGATTCAGATATTTCCAGTTTTATCAAGGAGGACAAA AATGGCAACATCAAGATCGTAAATCCTTACGAGCACCTTACTGATTTATCTCCTCCAGGT ACGCCTCCAACAATGGCCACAAGCGGATCAGTTTTAGGCTTAGATGCAATGGAATCAGGA AGTACTTTGAATTCGTTATCTTCTTCACCTTCTGGTTCCGATACTGAGGACGAAACATCA TTTAGCAAAGAACAAAGCAGTAAAAGTGAAAAAACTAGCAAGAAAGGAACAGCAGGGAGC GGTGAGACCGAGAAAAGATACATACGAACGATAAGATTGACTAATGACCAGTTAAAGTGC CTAAATTTAACTTATGGTGAAAATGATCTGAAATTTTCCGTAGATCACGGAAAAGCTATT GTTACGTCAAAATTATTCGTTTGGAGGTGGGATGTTCCAATTGTTATCAGTGATATTGAT GGCACCATCACAAAATCGGACGCTTTAGGCCATGTTCTGGCAATGATAGGAAAAGACTGG ACGCACTTGGGTGTAGCCAAGTTATTTAGCGAGATCTCCAGGAATGGCTATAATATACTC TATCTAACTGCAAGAAGTGCTGGACAAGCTGATTCCACGAGGAGTTATTTGCGATCAATT GAACAGAATGGCAGCAAACTACCAAATGGGCCTGTGATTTTATCACCCGATAGAACGATG GCTGCGTTAAGGCGGGAAGTAATACTAAAAAAACCTGAAGTCTTTAAAATCGCGTGTCTA AACGACATAAGATCCTTGTATTTTGAAGACAGTGATAACGAAGTGGATACAGAGGAAAAA TCAACACCATTTTTTGCCGGCTTTGGTAATAGGATTACTGATGCTTTATCTTACAGAACT GTGGGGATACCTAGTTCAAGAATTTTCACAATAAATACAGAGGGTGAGGTTCATATGGAA TTATTGGAGTTAGCAGGTTACAGAAGCTCCTATATTCATATCAATGAGCTTGTCGATCAT TTCTTTCCACCAGTCAGCCTTGATAGTGTCGATCTAAGAACTAATACTTCCATGGTTCCT GGCTCCCCCCCTAATAGAACGTTGGATAACTTTGACTCAGAAATTACTTCAGGTCGCAAA ACGCTATTTAGAGGCAATCAGGAAGAGAAATTCACAGACGTAAATTTTTGGAGAGACCCG TTAGTCGACATCGACAACTTATCGGATATTAGCAATGATGATTCTGATAACATCGATGAA GATACTGACGTATCACAACAAAGCAACATTAGTAGAAATAGGGCAAATTCAGTCAAAACC GCCAAGGTCACTAAAGCCCCGCAAAGAAATGTGAGCGGCAGCACAAATAACAACGAAGTT TTAGCCGCTTCGTCTGATGTAGAAAATGCGTCTGACCTGGTGAGTTCCCATAGTAGCTCA GGATCCACGCCCAATAAATCTACAATGTCCAAAGGGGACATTGGAAAACAAATATATTTG GAGCTAGGTTCTCCACTTGCATCGCCAAAACTAAGATATTTAGACGATATGGATGATGAA GACTCCAATTACAATAGAACTAAATCAAGGAGAGCATCTTCTGCAGCCGCGACTAGTATC GATAAAGAGTTCAAAAAGCTCTCTGTGTCAAAGGCCGGCGCTCCAACAAGAATTGTTTCA AAGATCAACGTTTCAAATGACGTACATTCACTTGGGAATTCAGATACCGAATCACGAAGG GAGCAAAGTGTTAATGAAACAGGGCGCAATCAGCTACCCCACAACTCAATGGACGATAAA GATTTGGATTCAAGAGTAAGCGATGAATTCGATGACGATGAATTCGACGAAGATGAATTC GAAGATTAA

Protein Properties

Pfam Domain Function

Not Available

Protein Residues

862

Protein Molecular Weight

95029.985

Protein Theoretical pI

Not Available

Signalling Regions

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Phosphatidic acid phosphohydrolase 1 MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKFQILKPSQKK VQVFINEKLSNMPMKLSDSGEAYFVFEMGDQVTDVPDELLVSPVMSATSSPPQSPETSIL EGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKNSETTGSLSPTESSTTTPPDS VEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLLLDTEGYKPNKNMMHDTDIQLKQ LLKDEFGNDSDISSFIKEDKNGNIKIVNPYEHLTDLSPPGTPPTMATSGSVLGLDAMESG STLNSLSSSPSGSDTEDETSFSKEQSSKSEKTSKKGTAGSGETEKRYIRTIRLTNDQLKC LNLTYGENDLKFSVDHGKAIVTSKLFVWRWDVPIVISDIDGTITKSDALGHVLAMIGKDW THLGVAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGPVILSPDRTM AALRREVILKKPEVFKIACLNDIRSLYFEDSDNEVDTEEKSTPFFAGFGNRITDALSYRT VGIPSSRIFTINTEGEVHMELLELAGYRSSYIHINELVDHFFPPVSLDSVDLRTNTSMVP GSPPNRTLDNFDSEITSGRKTLFRGNQEEKFTDVNFWRDPLVDIDNLSDISNDDSDNIDE DTDVSQQSNISRNRANSVKTAKVTKAPQRNVSGSTNNNEVLAASSDVENASDLVSSHSSS GSTPNKSTMSKGDIGKQIYLELGSPLASPKLRYLDDMDDEDSNYNRTKSRRASSAAATSI DKEFKKLSVSKAGAPTRIVSKINVSNDVHSLGNSDTESRREQSVNETGRNQLPHNSMDDK DLDSRVSDEFDDDEFDEDEFED

References

External Links

Resource	Link
Saccharomyces Genome Database	PAH1
Uniprot ID	P32567
Uniprot Name	PAH1

General Reference

Not Available