Mitogen-activated protein kinase HOG1 (P32485)

Identification
NameMitogen-activated protein kinase HOG1
Synonyms
  • MAP kinase HOG1
  • High osmolarity glycerol response protein 1
Gene NameHOG1
Enzyme ClassNot Available
Biological Properties
General Functiontranscription, DNA-templated
Specific FunctionMitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes. Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, phosphorylates SKO1, and converts it into an activator that subsequently recruits Swi/Snf and SAGA complexes. Activates the SMP1 transcription factor and the RCK2 kinase, both also involved in the regulation of the expression of a subset of osmotic stress-related genes. Phosphorylation of HSL1 by HOG1 leads to a G2 arrest essential for cell survival at high osmolarity. Mediates also cell-cycle arrest in G1 phase by the dual targeting of SIC1. Regulates MFA2 ARE-mediated translation in response to carbon source. Targets RDP3 histone deacetylase to osmoresponsive promoters to induce gene expression on stress. Plays an essential role in maintaining water homeostasis, arsenite detoxification, copper-resistance, hydrogen peroxide response, adaptation to citric acid stress, and repression of the mating pathway activity. Required for the Golgi apparatus localization of MNN1.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: low osmolarityPW002515 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
positive regulation of transcription from RNA polymerase II promoter
protein phosphorylation
cellular response to heat
hyperosmotic response
osmosensory signaling pathway
transcription, DNA-templated
MAP kinase activity
chromatin binding
cellular response to osmotic stress
positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
regulation of macroautophagy
regulation of nuclear cell cycle DNA replication
regulation of transcription from RNA polymerase II promoter in response to osmotic stress
ATP binding
response to arsenic-containing substance
nucleus
cytoplasm
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1308 bp ATGACCACTAACGAGGAATTCATTAGGACACAGATATTCGGTACAGTTTTCGAGATCACA AATAGATACAATGATTTAAACCCCGTTGGGATGGGGGCATTTGGGTTGGTTTGCTCAGCC ACGGACACTTTGACATCTCAGCCAGTTGCCATTAAGAAAATCATGAAACCTTTTTCCACT GCAGTGCTGGCCAAAAGGACATATCGTGAACTAAAACTACTAAAACATCTAAGACACGAG AACTTGATTTGCCTTCAGGACATATTTCTTTCTCCATTGGAAGATATATATTTTGTCACG GAATTACAAGGAACAGATTTACATAGACTCTTGCAAACAAGACCCTTGGAAAAGCAATTT GTTCAGTATTTCCTATACCAAATTCTAAGGGGTTTAAAATACGTTCACTCCGCGGGCGTC ATTCATAGAGATTTGAAACCGAGCAACATTCTGATTAATGAAAACTGTGATTTGAAGATT TGCGATTTCGGTCTAGCAAGAATTCAAGACCCTCAAATGACAGGCTATGTTTCCACTAGA TACTACAGGGCACCTGAAATCATGCTAACGTGGCAAAAATATGACGTCGAGGTCGACATT TGGTCCGCTGGTTGTATTTTTGCCGAAATGATTGAAGGTAAGCCTTTGTTCCCTGGGAAA GATCATGTTCACCAATTTTCGATCATCACTGACTTGTTGGGATCTCCGCCAAAGGATGTG ATAAATACTATTTGTTCCGAAAATACTCTAAAATTTGTTACTTCGTTACCACACAGAGAT CCAATTCCATTTTCTGAAAGATTTAAAACAGTCGAACCTGATGCCGTAGACCTTTTGGAA AAAATGCTGGTTTTTGATCCTAAGAAGAGAATCACTGCGGCGGATGCCTTGGCTCATCCT TATTCGGCTCCTTACCACGATCCAACGGATGAACCAGTAGCCGATGCCAAGTTCGATTGG CACTTTAATGACGCTGATCTGCCTGTCGATACCTGGCGTGTTATGATGTACTCAGAAATC CTAGACTTCCATAAGATTGGTGGCAGTGATGGACAGATTGATATATCTGCCACGTTTGAT GACCAAGTTGCTGCAGCCACCGCTGCCGCGGCGCAGGCACAGGCTCAGGCTCAGGCTCAA GTTCAGTTAAACATGGCTGCGCATTCGCATAATGGCGCTGGCACTACTGGAAATGATCAC TCAGATATAGCTGGTGGAAACAAAGTCAGCGATCATGTAGCTGCAAATGACACCATTACG GACTACGGTAACCAGGCCATACAGTACGCTAATGAGTTCCAACAGTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues435
Protein Molecular Weight48857.96
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Mitogen-activated protein kinase HOG1 MTTNEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFST AVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQF VQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTR YYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDV INTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHP YSAPYHDPTDEPVADAKFDWHFNDADLPVDTWRVMMYSEILDFHKIGGSDGQIDISATFD DQVAAATAAAAQAQAQAQAQVQLNMAAHSHNGAGTTGNDHSDIAGGNKVSDHVAANDTIT DYGNQAIQYANEFQQ
References
External Links
ResourceLink
Saccharomyces Genome Database HOG1
Uniprot IDP32485
Uniprot NameHOG1
General ReferenceNot Available