Mitogen-activated protein kinase HOG1 (P32485)
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| Name | Mitogen-activated protein kinase HOG1 | ||||||||||||||||||
| Synonyms |
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| Gene Name | HOG1 | ||||||||||||||||||
| Enzyme Class | Not Available | ||||||||||||||||||
| Biological Properties | |||||||||||||||||||
| General Function | transcription, DNA-templated | ||||||||||||||||||
| Specific Function | Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes. Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, phosphorylates SKO1, and converts it into an activator that subsequently recruits Swi/Snf and SAGA complexes. Activates the SMP1 transcription factor and the RCK2 kinase, both also involved in the regulation of the expression of a subset of osmotic stress-related genes. Phosphorylation of HSL1 by HOG1 leads to a G2 arrest essential for cell survival at high osmolarity. Mediates also cell-cycle arrest in G1 phase by the dual targeting of SIC1. Regulates MFA2 ARE-mediated translation in response to carbon source. Targets RDP3 histone deacetylase to osmoresponsive promoters to induce gene expression on stress. Plays an essential role in maintaining water homeostasis, arsenite detoxification, copper-resistance, hydrogen peroxide response, adaptation to citric acid stress, and repression of the mating pathway activity. Required for the Golgi apparatus localization of MNN1. | ||||||||||||||||||
| Cellular Location | Not Available | ||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | ||||||||||||||||||
| SMPDB Reactions | Not Available | ||||||||||||||||||
| KEGG Reactions | Not Available | ||||||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | |||||||||||||||||||
| Chromosome Location | Not Available | ||||||||||||||||||
| Locus | |||||||||||||||||||
| Gene Sequence | >1308 bp ATGACCACTAACGAGGAATTCATTAGGACACAGATATTCGGTACAGTTTTCGAGATCACA AATAGATACAATGATTTAAACCCCGTTGGGATGGGGGCATTTGGGTTGGTTTGCTCAGCC ACGGACACTTTGACATCTCAGCCAGTTGCCATTAAGAAAATCATGAAACCTTTTTCCACT GCAGTGCTGGCCAAAAGGACATATCGTGAACTAAAACTACTAAAACATCTAAGACACGAG AACTTGATTTGCCTTCAGGACATATTTCTTTCTCCATTGGAAGATATATATTTTGTCACG GAATTACAAGGAACAGATTTACATAGACTCTTGCAAACAAGACCCTTGGAAAAGCAATTT GTTCAGTATTTCCTATACCAAATTCTAAGGGGTTTAAAATACGTTCACTCCGCGGGCGTC ATTCATAGAGATTTGAAACCGAGCAACATTCTGATTAATGAAAACTGTGATTTGAAGATT TGCGATTTCGGTCTAGCAAGAATTCAAGACCCTCAAATGACAGGCTATGTTTCCACTAGA TACTACAGGGCACCTGAAATCATGCTAACGTGGCAAAAATATGACGTCGAGGTCGACATT TGGTCCGCTGGTTGTATTTTTGCCGAAATGATTGAAGGTAAGCCTTTGTTCCCTGGGAAA GATCATGTTCACCAATTTTCGATCATCACTGACTTGTTGGGATCTCCGCCAAAGGATGTG ATAAATACTATTTGTTCCGAAAATACTCTAAAATTTGTTACTTCGTTACCACACAGAGAT CCAATTCCATTTTCTGAAAGATTTAAAACAGTCGAACCTGATGCCGTAGACCTTTTGGAA AAAATGCTGGTTTTTGATCCTAAGAAGAGAATCACTGCGGCGGATGCCTTGGCTCATCCT TATTCGGCTCCTTACCACGATCCAACGGATGAACCAGTAGCCGATGCCAAGTTCGATTGG CACTTTAATGACGCTGATCTGCCTGTCGATACCTGGCGTGTTATGATGTACTCAGAAATC CTAGACTTCCATAAGATTGGTGGCAGTGATGGACAGATTGATATATCTGCCACGTTTGAT GACCAAGTTGCTGCAGCCACCGCTGCCGCGGCGCAGGCACAGGCTCAGGCTCAGGCTCAA GTTCAGTTAAACATGGCTGCGCATTCGCATAATGGCGCTGGCACTACTGGAAATGATCAC TCAGATATAGCTGGTGGAAACAAAGTCAGCGATCATGTAGCTGCAAATGACACCATTACG GACTACGGTAACCAGGCCATACAGTACGCTAATGAGTTCCAACAGTAA | ||||||||||||||||||
| Protein Properties | |||||||||||||||||||
| Pfam Domain Function | Not Available | ||||||||||||||||||
| Protein Residues | 435 | ||||||||||||||||||
| Protein Molecular Weight | 48857.96 | ||||||||||||||||||
| Protein Theoretical pI | Not Available | ||||||||||||||||||
| Signalling Regions | Not Available | ||||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||||
| Protein Sequence | >Mitogen-activated protein kinase HOG1 MTTNEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFST AVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQF VQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTR YYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDV INTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHP YSAPYHDPTDEPVADAKFDWHFNDADLPVDTWRVMMYSEILDFHKIGGSDGQIDISATFD DQVAAATAAAAQAQAQAQAQVQLNMAAHSHNGAGTTGNDHSDIAGGNKVSDHVAANDTIT DYGNQAIQYANEFQQ | ||||||||||||||||||
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| General Reference | Not Available | ||||||||||||||||||