V-type proton ATPase subunit d _ (P32366)

Identification
NameV-type proton ATPase subunit d _
Synonyms
  • V-ATPase subunit d
  • V-ATPase 39 kDa subunit
  • V-ATPase subunit M39
  • Vacuolar proton pump subunit d
Gene NameVMA6
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionVacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores
Cellular LocationVacuole membrane; Peripheral membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
protein complex
proton-transporting two-sector ATPase complex, proton-transporting domain
proton-transporting V-type ATPase, V0 domain
macromolecular complex
Function
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
Process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1038 bp ATGGAAGGCGTGTATTTCAATATTGACAATGGGTTTATTGAAGGTGTAGTGAGAGGCTAC AGAAATGGGTTGTTATCTAATAACCAATACATCACCTTAACACAATGTGACACGTTGGAA GATCTAAAATTACAATTATCATCAACTGATTATGGTAATTTTCTTTCCTCTGTTTCCTCA GAGTCTTTGACCACGTCATTGATTCAAGAATATGCTTCTAGCAAGTTGTACCACGAATTC AACTACATAAGAGACCAATCCAGTGGATCCACGAGAAAGTTCATGGACTATATCACTTAT GGTTACATGATCGACAATGTAGCATTGATGATTACAGGTACTATTCATGATCGTGATAAG GGTGAAATTTTACAACGTTGTCATCCGCTAGGTTGGTTTGATACTTTGCCTACGTTGAGT GTTGCTACTGATCTTGAATCCCTATACGAAACCGTATTGGTGGATACCCCACTGGCACCT TACTTCAAAAACTGTTTTGACACGGCAGAGGAGCTAGACGATATGAACATTGAAATTATT AGAAATAAGCTGTACAAGGCTTATTTAGAAGACTTTTACAATTTTGTCACTGAAGAAATT CCGGAACCTGCTAAAGAATGTATGCAAACATTACTAGGGTTTGAAGCTGACAGAAGAAGT ATCAATATTGCACTCAACTCTTTGCAAAGTTCAGATATTGACCCAGATTTGAAAAGTGAC TTGTTACCTAACATAGGTAAGTTGTACCCTCTTGCAACGTTTCACTTGGCGCAAGCCCAA GATTTCGAAGGAGTTAGAGCTGCTTTAGCTAACGTCTATGAGTATAGGGGATTTTTGGAG ACTGGTAACTTAGAAGATCACTTTTACCAATTGGAAATGGAACTATGTAGAGATGCTTTC ACGCAACAATTTGCCATCAGCACTGTTTGGGCCTGGATGAAATCCAAGGAACAAGAAGTT AGGAATATTACCTGGATTGCAGAATGTATCGCACAAAACCAAAGAGAAAGAATCAACAAT TATATTTCCGTTTATTAG
Protein Properties
Pfam Domain Function
Protein Residues345
Protein Molecular Weight39790.30078
Protein Theoretical pI4.22
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>V-type proton ATPase subunit d MEGVYFNIDNGFIEGVVRGYRNGLLSNNQYINLTQCDTLEDLKLQLSSTDYGNFLSSVSS ESLTTSLIQEYASSKLYHEFNYIRDQSSGSTRKFMDYITYGYMIDNVALMITGTIHDRDK GEILQRCHPLGWFDTLPTLSVATDLESLYETVLVDTPLAPYFKNCFDTAEELDDMNIEII RNKLYKAYLEDFYNFVTEEIPEPAKECMQTLLGFEADRRSINIALNSLQSSDIDPDLKSD LLPNIGKLYPLATFHLAQAQDFEGVRAALANVYEYRGFLETGNLEDHFYQLEMELCRDAF TQQFAISTVWAWMKSKEQEVRNITWIAECIAQNQRERINNYISVY
References
External Links
ResourceLink
Saccharomyces Genome Database VMA6
Uniprot IDP32366
Uniprot NameVA0D_YEAST
GenBank Gene IDL11584
Genebank Protein ID173171
General Reference
  • Bauerle, C., Ho, M. N., Lindorfer, M. A., Stevens, T. H. (1993). "The Saccharomyces cerevisiae VMA6 gene encodes the 36-kDa subunit of the vacuolar H(+)-ATPase membrane sector." J Biol Chem 268:12749-12757.8509410
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106