Aspartic proteinase 3 (P32329)

Identification
NameAspartic proteinase 3
Synonyms
  • Proprotein convertase
  • Yapsin-1
Gene NameYPS1
Enzyme ClassNot Available
Biological Properties
General Functionsignal transduction involved in filamentous growth
Specific FunctionCleaves proteins C-terminally to mono- and paired-basic residues. Involved in the shedding of a subset of GPI-anchored plasma membrane proteins from the cell surface, including itself, GAS1 and MSB2. May also play a role in the maturation of GPI-mannoproteins associated with the cell wall. Can process the alpha-mating factor precursor. Required for cell wall integrity.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: starvation test 1PW003483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
aspartic-type endopeptidase activity
protein catabolic process
fungal-type cell wall organization
anchored component of plasma membrane
peptide mating pheromone maturation involved in conjugation with cellular fusion
protein processing
signal transduction involved in filamentous growth
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1710 bp ATGAAACTGAAAACTGTAAGATCTGCGGTCCTTTCGTCACTCTTTGCATCGCAGGTTCTC GGTAAGATAATACCAGCAGCAAACAAGCGCGACGACGACTCGAATTCCAAGTTCGTCAAG TTGCCCTTTCATAAGCTTTACGGGGACTCGCTAGAAAATGTGGGAAGCGACAAAAAACCG GAAGTACGCCTATTGAAGAGGGCTGACGGTTATGAAGAAATTATAATTACCAACCAGCAA AGTTTCTATTCGGTGGACTTGGAAGTGGGCACGCCACCACAGAACGTAACGGTCCTGGTG GACACAGGCTCCTCTGATCTATGGATTATGGGCTCGGATAATCCATACTGTTCTTCGAAC AGTATGGGTAGTAGCCGGAGACGTGTTATTGACAAACGTGATGATTCGTCAAGCGGCGGA TCTTTGATTAATGATATAAACCCATTTGGCTGGTTGACGGGAACGGGCAGTGCCATTGGC CCCACTGCTACGGGCTTAGGAGGCGGTTCAGGTACGGCAACTCAATCCGTGCCTGCTTCG GAAGCCACCATGGACTGTCAACAATACGGGACATTTTCCACTTCGGGCTCTTCTACATTT AGATCAAACAACACCTATTTCAGTATTAGCTACGGTGATGGGACTTTTGCCTCCGGTACT TTTGGTACGGATGTTTTGGATTTAAGCGACTTGAACGTTACCGGGTTGTCTTTTGCCGTT GCCAATGAAACGAATTCTACTATGGGTGTGTTAGGTATTGGTTTGCCCGAATTAGAAGTC ACTTATTCTGGCTCTACTGCGTCTCATAGTGGAAAAGCTTATAAATACGACAACTTCCCC ATTGTATTGAAAAATTCTGGTGCTATCAAAAGCAACACATATTCTTTGTATTTGAACGAC TCGGACGCTATGCATGGCACCATTTTGTTCGGAGCCGTGGACCACAGTAAATATACCGGC ACCTTATACACAATCCCCATCGTAAACACTCTGAGTGCTAGTGGATTTAGCTCTCCCATT CAATTTGATGTCACTATTAATGGTATCGGTATTAGTGATTCTGGGAGTAGTAACAAGACC TTGACTACCACTAAAATACCTGCTTTGTTGGATTCCGGTACTACTTTGACTTATTTACCT CAAACAGTGGTAAGTATGATCGCTACTGAACTAGGTGCGCAATACTCTTCCAGGATAGGG TATTACGTATTGGACTGTCCATCTGATGATAGTATGGAAATAGTGTTCGATTTTGGTGGT TTTCACATCAATGCACCACTTTCGAGTTTTATCTTGAGTACTGGCACTACATGTCTTTTA GGTATTATCCCAACGAGTGATGACACAGGTACCATTTTGGGTGATTCATTTTTGACTAAC GCGTACGTGGTTTATGATTTGGAGAATCTTGAAATATCCATGGCACAAGCTCGCTATAAT ACCACAAGCGAAAATATCGAAATTATTACATCCTCTGTTCCAAGCGCCGTAAAGGCACCA GGCTATACAAACACTTGGTCCACAAGTGCATCTATTGTTACCGGTGGTAACATATTTACT GTAAATTCCTCACAAACTGCTTCCTTTAGCGGTAACCTGACGACCAGTACTGCATCCGCC ACTTCTACATCAAGTAAAAGAAATGTTGGTGATCATATAGTTCCATCTTTACCCCTCACA TTAATTTCTCTTCTTTTTGCATTCATCTGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues569
Protein Molecular Weight60009.13
Protein Theoretical pINot Available
PDB Fileshow
Signalling Regions
  • 1-21
Transmembrane RegionsNot Available
Protein Sequence>Aspartic proteinase 3 MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKP EVRLLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSN SMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPAS EATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAV ANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLND SDAMHGTILFGAVDHSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKT LTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGG FHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYN TTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASA TSTSSKRNVGDHIVPSLPLTLISLLFAFI
References
External Links
ResourceLink
Saccharomyces Genome Database YPS1
Uniprot IDP32329
Uniprot NameYPS1
PDB ID
1YPS
General ReferenceNot Available