| Identification |
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| Name | Nucleoside transporter FUN26 |
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| Synonyms | Not Available |
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| Gene Name | FUN26 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in nucleoside transmembrane transporter activity |
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| Specific Function | Has broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes |
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| Cellular Location | Membrane; Multi-pass membrane protein (Potential) |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00051 | Cytidine | Show | | YMDB00058 | Adenosine | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| cell part | | membrane | | Function |
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| substrate-specific transmembrane transporter activity | | nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity | | nucleoside transmembrane transporter activity | | transporter activity | | transmembrane transporter activity | | Process |
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| establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 1 |
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| Locus | YAL022C |
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| Gene Sequence | >1554 bp
ATGAGTACTAGTGCGGACACTGATACCATCAAGAAGCCAATCCTTGCGGTGCCAGAGCCT
GCACTGGCCGATACGCATTCAGAGGAGATATCACGCTCTGGAGAAGAACATGAATCAGAG
AACAACGAGCACTCAGATGAAGAAGGCGATAATTATTCTGAAAGAGAGCAATCTGTGTCA
ACCGAACCACTGGATACATTGCCGTTAAGAAAAAAGTTGAAAAATCTTTCATATATTACA
TTTTTCGCCATAGGAATAGGTCTTTTATGGCCGTGGAACTGTATCCTCAGTGCCTCGCAA
TATTTTAAGCACGATATTTTCAAAGACACCTCCATTTGGGCAAAGATCTTCACAAGCTCT
ATGATGTCCTTTTCTACCATATCGTCAATGCTGTTCAACATCTACTTGGCCAAAAGACAG
TACAAATACTCGAGAAGGGTCATAAACGGGCTTGTGTGGGAGATTATTGTCTTTACTGTC
ATGTGCTTCTTTACAATTTTGCATTTCCTTTTACCTAAATGGTTCAATTTCATGTTTATA
ATGATGCTTGTAGTGATCAGTTCCATGGGGACAGCCATGACACAGAATGGTATCATGGCC
ATAGCCAACGTCTTCGGTTCCGAGTACAGTCAAGGTGTCATGGTGGGGCAAGCCGTTGCT
GGTGTCCTGCCCTCCCTAGTGCTTTTTGCCCTAGCTTTCATCGAGAACTCTTCTGTGTCT
ACTACGGGCGGGATTCTTCTATACTTTTTTACCACAACACTCGTGGTCACCATTTGTGTG
GTCATGTTCAGCGTGAGCAAAATCAGTCGGAAAGTGAACGAGAATTGGAATGTGGAAGAC
GGACATATCACTGATGTGTTGTTAGGGTCTCTGCGCTCCAATGAGGAGGAAATCCGTATT
GTTGGCCGCATTGACCAAATGGAGGATGAAGACCACCGCCGCACCAACGGCACTCGCGAC
GACAACGACGAAGGTGAGGAACTCCAACTAAAAGTGCCTTTCGAGGTCTTATTTGCCAAA
CTAAAGTACCTGGTTCTTTCCATATTCACCACGTTTGTCGTAACTCTTGTTTTTCCTGTA
TTTGCGTCTGCCACCTACGTGACAGGGCTTCCTTTAAGCAACGCACAGTACATACCTCTC
ATATTCACGCTGTGGAACCTAGGCGACCTTTACGGAAGAGTCATTGCCGACTGGCCCATG
TTCCGTGACCAGAAATTTACGCCACGCAAAACCTTCATCTACTCATTGTTGCGGGTGGCC
GCAATACCACTGTTCTTGATGTTCACAGCCATCACCTCCTCTTCAAGCGGCGATGAAGAG
CACAATGGCTCCGTAATCGTTGACTTGTGTTACATGCTACTGCAGTTCCTTTTCGGCGTA
ACCAACGGGCACGTCATCTCTATGAGTTTCATGAAGGTGCCAGAGCAACTGGACAACGAC
GACGAGAAGGAAGCGGCCGGTGGATTCACTAATATTTTCGTTTCTACAGGACTAGCTCTG
GGCAGCATCATAAGCTACGTATTCGTCTTCATAATTGACTTTATTATCAGGTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 517 |
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| Protein Molecular Weight | 58316.69922 |
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| Protein Theoretical pI | 4.69 |
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| Signalling Regions | |
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| Transmembrane Regions | - 76-96
- 116-136
- 151-171
- 174-194
- 214-234
- 243-263
- 344-364
- 367-387
- 411-431
- 446-466
- 492-512
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| Protein Sequence | >Nucleoside transporter FUN26
MSTSADTDTIKKPILAVPEPALADTHSEEISRSGEEHESENNEHSDEEGDNYSEREQSVS
TEPLDTLPLRKKLKNLSYITFFAIGIGLLWPWNCILSASQYFKHDIFKDTSIWAKIFTSS
MMSFSTISSMLFNIYLAKRQYKYSRRVINGLVWEIIVFTVMCFFTILHFLLPKWFNFMFI
MMLVVISSMGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFALAFIENSSVS
TTGGILLYFFTTTLVVTICVVMFSVSKISRKVNENWNVEDGHITDVLLGSLRSNEEEIRI
VGRIDQMEDEDHRRTNGTRDDNDEGEELQLKVPFEVLFAKLKYLVLSIFTTFVVTLVFPV
FASATYVTGLPLSNAQYIPLIFTLWNLGDLYGRVIADWPMFRDQKFTPRKTFIYSLLRVA
AIPLFLMFTAITSSSSGDEEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVPEQLDND
DEKEAAGGFTNIFVSTGLALGSIISYVFVFIIDFIIR |
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| References |
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| External Links | |
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| General Reference | - Ouellette, B. F., Clark, M. W., Keng, T., Storms, R. K., Zhong, W., Zeng, B., Fortin, N., Delaney, S., Barton, A., Kaback, D. B., et, a. l. .. (1993). "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes." Genome 36:32-42.8458570
- Bussey, H., Kaback, D. B., Zhong, W., Vo, D. T., Clark, M. W., Fortin, N., Hall, J., Ouellette, B. F., Keng, T., Barton, A. B., et, a. l. .. (1995). "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A 92:3809-3813.7731988
- Vickers, M. F., Yao, S. Y., Baldwin, S. A., Young, J. D., Cass, C. E. (2000). "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes." J Biol Chem 275:25931-25938.10827169
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
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