Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (P29703)

Identification
NameProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms
  • CAAX farnesyltransferase subunit alpha
  • FTase-alpha
  • Ras proteins prenyltransferase subunit alpha
  • Type I protein geranyl-geranyltransferase subunit alpha
  • GGTase-I-alpha
Gene NameRAM2
Enzyme Class
Biological Properties
General FunctionInvolved in protein prenyltransferase activity
Specific FunctionCatalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00219PyrophosphateShow
YMDB00229Farnesyl pyrophosphateShow
YMDB003592-trans,6-trans,10-trans-geranylgeranyl diphosphateShow
YMDB00631geranylgeranyl diphosphateShow
GO Classification
Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
prenyltransferase activity
protein prenyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid lipidation
protein prenylation
protein amino acid prenylation
Gene Properties
Chromosome Locationchromosome 11
LocusYKL019W
Gene Sequence>951 bp ATGGAGGAGTACGATTATTCAGACGTTAAACCTTTGCCCATTGAGACAGACTTGCAGGAT GAACTGTGCAGGATTATGTATACCGAGGATTATAAGCGGTTGATGGGACTCGCAAGGGCT CTGATCAGCCTTAACGAACTGTCACCCAGGGCACTACAGCTAACAGCCGAAATTATCGAC GTGGCGCCAGCCTTCTACACCATATGGAACTACCGATTCAATATCGTCAGGCACATGATG AGTGAATCCGAAGACACTGTCTTGTACCTGAACAAGGAATTAGACTGGCTAGATGAAGTT ACGCTGAATAATCCAAAGAACTATCAGATCTGGTCCTATAGACAGTCTCTTTTGAAGCTA CATCCGTCTCCTTCCTTCAAAAGAGAGCTGCCTATCTTAAAACTGATGATTGATGATGAT TCCAAGAATTATCACGTTTGGTCGTACAGAAAGTGGTGCTGTTTGTTCTTCAGTGACTTT CAACATGAGCTCGCCTACGCCAGCGACCTCATCGAGACAGACATTTATAACAACAGCGCA TGGACTCATAGGATGTTTTACTGGGTGAACGCTAAAGATGTCATTTCAAAAGTGGAATTG GCCGACGAGCTCCAGTTCATTATGGACAAGATTCAATTGGTTCCGCAGAACATCAGTCCG TGGACCTACCTCCGTGGTTTCCAAGAGCTATTCCATGATAGGCTACAGTGGGATAGCAAA GTAGTCGACTTCGCCACAACCTTCATCGGTGACGTATTGTCACTTCCAATTGGCTCACCA GAGGATTTGCCCGAGATCGAGTCCTCATATGCCCTGGAATTCCTGGCATATCACTGGGGG GCAGACCCTTGTACCCGAGACAACGCTGTTAAGGCCTATAGCTTGCTAGCAATCAAATAC GATCCTATTAGAAAAAACTTGTGGCACCACAAAATAAATAATCTGAACTGA
Protein Properties
Pfam Domain Function
Protein Residues316
Protein Molecular Weight37507.30078
Protein Theoretical pI4.75
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIID VAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKL HPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSA WTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSK VVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKY DPIRKNLWHHKINNLN
References
External Links
ResourceLink
Saccharomyces Genome Database RAM2
Uniprot IDP29703
Uniprot NameFNTA_YEAST
GenBank Gene IDM88584
Genebank Protein ID172359
General Reference
  • He, B., Chen, P., Chen, S. Y., Vancura, K. L., Michaelis, S., Powers, S. (1991). "RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins." Proc Natl Acad Sci U S A 88:11373-11377.1763050
  • Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
  • Burkett, T. J., Garfinkel, D. J. (1994). "Molecular characterization of the SPT23 gene: a dosage-dependent suppressor of Ty-induced promoter mutations from Saccharomyces cerevisiae." Yeast 10:81-92.8203154
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106