| Identification |
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| Name | Pantothenate transporter FEN2 |
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| Synonyms | - Fenpropimorph resistance protein 2
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| Gene Name | FEN2 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transmembrane transport |
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| Specific Function | Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance |
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| Cellular Location | Cell membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00203 | (R)-Pantothenic acid | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| Not Available | | Process |
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| establishment of localization | | transport | | transmembrane transport |
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| Gene Properties |
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| Chromosome Location | chromosome 3 |
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| Locus | YCR028C |
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| Gene Sequence | >1539 bp
ATGGTAGCAACAATAATGCAGACGACAACAACTGTGCTGACGACAGTCGCCGCAATGTCT
ACTACCTTAGCATCAAATTACATATCTTCGCAAGCTAGTTCCTCGACGAGTGTAACAACA
GTAACGACAATAGCGACATCAATACGCTCTACACCGTCTAATCTACTCTTTTCTAATGTG
GCGGCTCAGCCAAAATCATCTTCAGCAAGCACAATTGGGCTTTCAATCGGACTTCCCATC
GGAATATTCTGTTTCGGATTACTTATCCTTTTGTGTTATTTCTACCTTAAAAGGAATTCG
GTGTCCATTTCAAATCCACCCATGTCAGCTACGATTCCAAGGGAAGAGGAATATTGTCGC
CGCACTAATTGGTTCTCACGGTTATTTTGGCAGAGTAAGTGTGAGGATCAGAATTCATAT
TCTAATCGTGATATTGAGAAGTATAACGACACCCAGTGGACCTCGGGTGATAACATGTCT
TCAAAAATACAGTACAAAATTTCCAAACCCATAATACCGCAGCATATACTGACACCTAAG
AAAACGGTGAAGAACCCATATGCTTGGTCTGGTAAAAACATTTCGTTAGACCCCAAAGTG
AACGAAATGGAGGAAGAGAAAGTTGTGGATGCATTCCTGTATACTAAACCACCGAATATT
GTCCATATTGAATCCAGCATGCCCTCGTATAATGATTTACCTTCTCAAAAAACGGTGTCC
TCAAAGAAAACTGCGTTAAAAACGAGTGAGAAATGGAGTTACGAATCTCCACTATCTCGA
TGGTTCTTGAGGGGTTCTACATACTTTAAGGATTATGGCTTATCAAAGACCTCTTTAAAG
ACCCCAACTGGGGCTCCACAACTGAAGCAAATGAAAATGCTCTCCCGGATAAGTAAGGGT
TACTTCAATGAGTCAGATATAATGCCTGACGAACGATCGCCCATCTTGGAGTATAATAAC
ACGCCTCTGGATGCAAATGACAGTGTGAATAACTTGGGTAATACCACGCCAGATTCACAA
ATCACATCTTATCGCAACAATAACATCGATCTAATCACGGCAAGACCCCATTCAGTGATA
TACGGTACTACTGCACAACAAACTTTGGAAACCAACTTCAATGATCATCATGACTGCAAT
AAAAGCACTGAGAAACACGAGTTGATAATACCCACCCCATCAAAACCACTAAAGAAAAGG
AAAAAAAGAAGACAAAGTAAAATGTATCAGCATTTACAACATTTGTCACGTTCTAAACCA
TTGCCGCTTACTCCAAACTCCAAATATAATGGGGAGGCTAGCGTCCAATTAGGGAAGACA
TATACAGTTATTCAGGATTACGAGCCTAGATTGACAGACGAAATAAGAATCTCGCTGGGT
GAAAAAGTTAAAATTCTGGCCACTCATACCGATGGATGGTGTCTGGTAGAAAAGTGTAAT
ACACAAAAGGGTTCTATTCACGTCAGTGTTGACGATAAAAGATACCTCAATGAAGATAGA
GGCATTGTGCCTGGTGACTGTCTCCAAGAATACGACTGA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 512 |
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| Protein Molecular Weight | 58256.0 |
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| Protein Theoretical pI | 7.25 |
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| Signalling Regions | |
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| Transmembrane Regions | - 28-48
- 80-100
- 103-123
- 133-153
- 165-185
- 199-219
- 272-292
- 313-333
- 343-363
- 373-393
- 402-422
- 435-455
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| Protein Sequence | >Pantothenate transporter FEN2
MMKESKSITQHEVERESVSSKRAIKKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYI
SGMKEDLKMVGNDLTVSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMY
KVTSFKHICAIRFFQALFESCTFSGTHFVLGSWYKEDELPIRSAIFTGSGLVGSMFSGFM
QTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIFN
EQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSLVWVLGGENLGFASNSTFALWL
QNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRA
DPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWWSI
LFFASDMVPKFERGCYALLATAISSGIVSVVIRSLQIKENLSKKQVPYIDANDMPGEDDD
DDNQDNENDGDDESMEVELHNEEMAEISNPFR |
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| References |
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| External Links | |
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| General Reference | - Agostoni Carbone, M. L., Panzeri, L., Muzi Falconi, M., Carcano, C., Plevani, P., Lucchini, G. (1992). "Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28." Yeast 8:805-812.1332309
- Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
- Koonin, E. V., Bork, P., Sander, C. (1994). "Yeast chromosome III: new gene functions." EMBO J 13:493-503.8313894
- Marcireau, C., Joets, J., Pousset, D., Guilloton, M., Karst, F. (1996). "FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast." Yeast 12:531-539.8771708
- Stolz, J., Sauer, N. (1999). "The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter." J Biol Chem 274:18747-18752.10373490
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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