Identification |
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Name | Phosphomevalonate kinase |
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Synonyms | Not Available |
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Gene Name | ERG8 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in ATP binding |
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Specific Function | ATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate |
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Cellular Location | Cytoplasm |
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SMPDB Pathways | Cholesterol biosynthesis and metabolism CE(10:0) | PW002545 | | Cholesterol biosynthesis and metabolism CE(12:0) | PW002548 | | Cholesterol biosynthesis and metabolism CE(14:0) | PW002544 | | Cholesterol biosynthesis and metabolism CE(18:0) | PW002551 | | Terpenoid backbone biosynthesis | PW002485 | |
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KEGG Pathways | Terpenoid backbone biosynthesis | ec00900 | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00109 | Adenosine triphosphate | Show | YMDB00181 | Mevalonic acid-5P | Show | YMDB00403 | 5-Diphosphomevalonic acid | Show | YMDB00914 | ADP | Show |
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GO Classification | Component |
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Not Available | Function |
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binding | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | adenyl ribonucleotide binding | ATP binding | kinase activity | catalytic activity | transferase activity | transferase activity, transferring phosphorus-containing groups | Process |
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cellular metabolic process | phosphorus metabolic process | phosphate metabolic process | phosphorylation | metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 13 |
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Locus | YMR220W |
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Gene Sequence | >1356 bp
ATGTCAGAGTTGAGAGCCTTCAGTGCCCCAGGGAAAGCGTTACTAGCTGGTGGATATTTA
GTTTTAGATACAAAATATGAAGCATTTGTAGTCGGATTATCGGCAAGAATGCATGCTGTA
GCCCATCCTTACGGTTCATTGCAAGGGTCTGATAAGTTTGAAGTGCGTGTGAAAAGTAAA
CAATTTAAAGATGGGGAGTGGCTGTACCATATAAGTCCTAAAAGTGGCTTCATTCCTGTT
TCGATAGGCGGATCTAAGAACCCTTTCATTGAAAAAGTTATCGCTAACGTATTTAGCTAC
TTTAAACCTAACATGGACGACTACTGCAATAGAAACTTGTTCGTTATTGATATTTTCTCT
GATGATGCCTACCATTCTCAGGAGGATAGCGTTACCGAACATCGTGGCAACAGAAGATTG
AGTTTTCATTCGCACAGAATTGAAGAAGTTCCCAAAACAGGGCTGGGCTCCTCGGCAGGT
TTAGTCACAGTTTTAACTACAGCTTTGGCCTCCTTTTTTGTATCGGACCTGGAAAATAAT
GTAGACAAATATAGAGAAGTTATTCATAATTTAGCACAAGTTGCTCATTGTCAAGCTCAG
GGTAAAATTGGAAGCGGGTTTGATGTAGCGGCGGCAGCATATGGATCTATCAGATATAGA
AGATTCCCACCCGCATTAATCTCTAATTTGCCAGATATTGGAAGTGCTACTTACGGCAGT
AAACTGGCGCATTTGGTTGATGAAGAAGACTGGAATATTACGATTAAAAGTAACCATTTA
CCTTCGGGATTAACTTTATGGATGGGCGATATTAAGAATGGTTCAGAAACAGTAAAACTG
GTCCAGAAGGTAAAAAATTGGTATGATTCGCATATGCCAGAAAGCTTGAAAATATATACA
GAACTCGATCATGCAAATTCTAGATTTATGGATGGACTATCTAAACTAGATCGCTTACAC
GAGACTCATGACGATTACAGCGATCAGATATTTGAGTCTCTTGAGAGGAATGACTGTACC
TGTCAAAAGTATCCTGAAATCACAGAAGTTAGAGATGCAGTTGCCACAATTAGACGTTCC
TTTAGAAAAATAACTAAAGAATCTGGTGCCGATATCGAACCTCCCGTACAAACTAGCTTA
TTGGATGATTGCCAGACCTTAAAAGGAGTTCTTACTTGCTTAATACCTGGTGCTGGTGGT
TATGACGCCATTGCAGTGATTACTAAGCAAGATGTTGATCTTAGGGCTCAAACCGCTAAT
GACAAAAGATTTTCTAAGGTTCAATGGCTGGATGTAACTCAGGCTGACTGGGGTGTTAGG
AAAGAAAAAGATCCGGAAACTTATCTTGATAAATAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 451 |
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Protein Molecular Weight | 50454.39844 |
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Protein Theoretical pI | 6.46 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Phosphomevalonate kinase
MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSK
QFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFS
DDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENN
VDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGS
KLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYT
ELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRS
FRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTAN
DKRFSKVQWLDVTQADWGVRKEKDPETYLDK |
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References |
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External Links | |
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General Reference | - Tsay, Y. H., Robinson, G. W. (1991). "Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase." Mol Cell Biol 11:620-631.1846667
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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