Transcriptional regulator URE2 (P23202)

Identification
NameTranscriptional regulator URE2
Synonyms
  • Disulfide reductase
  • Glutathione peroxidase
Gene NameURE2
Enzyme ClassNot Available
Biological Properties
General Functionresponse to aluminum ion
Specific FunctionPlays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites.
Cellular LocationNot Available
SMPDB Pathways
TOR signalling pathway: Rapamycin based repressionPW002514 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
glutathione metabolic process
protein urmylation
regulation of nitrogen utilization
cytosol
nitrate assimilation
response to aluminum ion
glutathione peroxidase activity
glutathione transferase activity
phosphoprotein binding
transcription corepressor activity
cytoplasmic sequestering of protein
cytoplasmic sequestering of transcription factor
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1065 bp ATGATGAATAACAACGGCAACCAAGTGTCGAATCTCTCCAATGCGCTCCGTCAAGTAAAC ATAGGAAACAGGAACAGTAATACAACCACCGATCAAAGTAATATAAATTTTGAATTTTCA ACAGGTGTAAATAATAATAATAATAACAATAGCAGTAGTAATAACAATAATGTTCAAAAC AATAACAGCGGCCGCAATGGTAGCCAAAATAATGATAACGAGAATAATATCAAGAATACC TTAGAACAACATCGACAACAACAACAGGCATTTTCGGATATGAGTCACGTGGAGTATTCC AGAATTACAAAATTTTTTCAAGAACAACCACTGGAGGGATATACCCTTTTCTCTCACAGG TCTGCGCCTAATGGATTCAAAGTTGCTATAGTACTAAGTGAACTTGGATTTCATTATAAC ACAATCTTCCTAGATTTCAATCTTGGCGAACATAGGGCCCCCGAATTTGTGTCTGTGAAC CCTAATGCAAGAGTTCCAGCTTTAATCGATCATGGTATGGACAACTTGTCTATTTGGGAA TCAGGGGCGATTTTATTACATTTGGTAAATAAATATTACAAAGAGACTGGTAATCCATTA CTCTGGTCCGATGATTTAGCTGACCAATCACAAATCAACGCATGGTTGTTCTTCCAAACG TCAGGGCATGCGCCAATGATTGGACAAGCTTTACATTTCAGATACTTCCATTCACAAAAG ATAGCAAGTGCTGTAGAAAGATATACGGATGAGGTTAGAAGAGTTTACGGTGTAGTGGAG ATGGCCTTGGCTGAACGTAGAGAAGCGCTGGTGATGGAATTAGACACGGAAAATGCGGCT GCATACTCAGCTGGTACAACACCAATGTCACAAAGTCGTTTCTTTGATTATCCCGTATGG CTTGTAGGAGATAAATTAACTATAGCAGATTTGGCCTTTGTCCCATGGAATAATGTCGTG GATAGAATTGGCATTAATATCAAAATTGAATTTCCAGAAGTTTACAAATGGACGAAGCAT ATGATGAGAAGACCCGCGGTCATCAAGGCATTGCGTGGTGAATGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues354
Protein Molecular Weight40270.555
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Transcriptional regulator URE2 MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQN NNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHR SAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWE SGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQK IASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVW LVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
References
External Links
ResourceLink
Saccharomyces Genome Database URE2
Uniprot IDP23202
Uniprot NameURE2
PDB ID
1G6W
General ReferenceNot Available