Identification |
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Name | Methionyl-tRNA synthetase, mitochondrial |
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Synonyms | - Methionine--tRNA ligase
- MetRS
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Gene Name | MSM1 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in nucleotide binding |
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Specific Function | ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met) |
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Cellular Location | Mitochondrion matrix |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00097 | Adenosine monophosphate | Show | YMDB00109 | Adenosine triphosphate | Show | YMDB00219 | Pyrophosphate | Show | YMDB00318 | L-Methionine | Show | YMDB16175 | Selenomethionine | Show |
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GO Classification | Component |
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cell part | intracellular part | cytoplasm | Function |
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ATP binding | ligase activity, forming carbon-oxygen bonds | ligase activity, forming aminoacyl-tRNA and related compounds | catalytic activity | aminoacyl-tRNA ligase activity | nucleotide binding | ligase activity | binding | nucleoside binding | purine nucleoside binding | adenyl nucleotide binding | methionine-tRNA ligase activity | adenyl ribonucleotide binding | Process |
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metabolic process | macromolecule metabolic process | cellular macromolecule metabolic process | RNA metabolic process | ncRNA metabolic process | biosynthetic process | tRNA metabolic process | tRNA aminoacylation | tRNA aminoacylation for protein translation | macromolecule biosynthetic process | cellular macromolecule biosynthetic process | translation | methionyl-tRNA aminoacylation |
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Gene Properties |
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Chromosome Location | chromosome 7 |
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Locus | YGR171C |
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Gene Sequence | >1728 bp
ATGCAATGTCGATCAATTGTGCATCGTCTGTACTCTAAGATCTCCCACGTAACGACGCCA
ATTTTCTATCCCAATGCCAAACCGCACCTCGGCCATCTTTACTCCAGCTTATTAAGTGAC
GTTTACCATCGATGGCAATTATTTAAAGGTAATCTATCCTTCTTTACCACAGGTACTGAT
GAACATGGATTGAAAATCCAGTGTGCTAGTGAAAGCAATGGCTTCGATCAGCCAAAAAAG
TTCGTCGATAAGCTATACCCAGAGTTTGTTCAATTAGACAAAATATATGGCATTAATTAT
ACAAGATTTATAAGGACTACGGATCCTGACCACATTGAAAACGTGATGAAATTATGGGAA
CTTTGTTTGAAAAATGGCTATATTTACATGGGCGAACATAAGGGTTGGTATTCCATTTCT
GATGAAACATTCTATCCTGAATCCAAGGTTATTAAAGACCCCAAAAATGATGGTAAGTAT
CTGAATACAGAATCGAAAAACGAAGTAGTTTATCAGTCAGAGACAAATTACTTCTTTAGG
CTATCCTTATTTAACAAGAAAATAGTTGACCATATAAGAAAGAATCCAGATTTCATTTTT
CCTGCTTCTAAAAGAGACCAAATTCTAAAAGAACTAGAAACCGGTGGGACATTGCCAGAT
TTATCGATATCGAGACCCTCTGCGAGACTTAAATGGGGTATACCGACTCCTAATGATCCG
TCCCAAAAAGTTTATGTGTGGTTTGATGCCTTGTGTAACTACCTCTCCTCCATCGGTGGC
ATACCGTCCATCTTGAGTAATGCTACTGAAGTAGTTTCAAGACATTATAGCGACAAATCA
AACGTAAAAGGCCAATTGTTAATACCATACCCAAAAGAAGTGCAGCGAAACACCATTCAC
GTGATAGGAAAGGATATCGCGAAATTCCATACCGTATATTGGCCTTCTTTTTTACTGGCT
GCTGGACTGCCTTTACCAAGACAAATTGTTGTTCATGGACACTGGCTCTGCAATGGAATG
AAAATGTCCAAAAGTTTGGGTAATGTTGTAGATCCGATTGATATGGCACGTTATTATGGA
GCCGATATTGTGCGTTGGTTCTTGTTAGAAAATTCTAAACTGGAAGAGGACGGCGATTTT
CAAGAAGCCAAATTATACGAGACAAGAGAGCTTTTAGTATCCAAATGGGGCAATCTGATT
AACAGATGTTGTGGCTCGAAATTCAATATTGAAAGAGCTGTTATGAAATTTAGCGACAAG
GCAAATTTTCAATTTCAGGAGATTTTCCAAAATGAACCAATAGTCTCCGAACGAATTGAG
AATCTGGCTAAACTACTCAACAAATCACAAGAGGTTTTTGACGAAAAAATAGCCATATTC
CAGTATCCTCAACTGCTAAGGCATGTTTGGAGTATTATCAACGATGCAAATACTTTGGTT
CAAAATAGTAAACCTTGGGAGAGGGAATTAGATCAACAAGACAATATAATATTTTTGGCT
ATGGAAACGTCTAGAATCCTCTCCATTTTATGCCAATCCATTATACCATCTCTCTCACAA
AGTTTCCTAGATCGTATTGATGTTTCAAAGGAGAAAAGGACTATAAATTATGCTAGATTG
GGTTCCGATAAAACATATGGAAAGCAATCTAACAAGAAAGGCCGAGAAGTACCTTTGAAA
AAAATTCCATTCAGGTTGCAAGAGGAACAAACGAATATGAGGTCATGA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 575 |
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Protein Molecular Weight | 66733.89844 |
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Protein Theoretical pI | 9.07 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Methionyl-tRNA synthetase, mitochondrial
MQCRSIVHRLYSKVSHVTTPIFYPNAKPHLGHLYSSLLSDVYHRWQLFKGNLSFFTTGTD
EHGLKIQCASESNGFDQPKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWE
LCLKNGYIYMGEHKGWYSISDETFYPESKVIKDPKNDGKYLNTESKNEVVYQSETNYFFR
LSLFNKKIVDHIRKNPDFIFPASKRDQILKELETGGTLPDLSISRPSARLKWGIPTPNDP
SQKVYVWFDALCNYLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQRNTIH
VIGKDIAKFHTVYWPSFLLAAGLPLPRQIVVHGHWLCNGMKMSKSLGNVVDPIDMARYYG
ADIVRWFLLENSKLEEDGDFQEAKLYETRELLVSKWGNLINRCCGSKFNIERAVMKFSDK
ANFQFQEIFQNEPIVSERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSIINDANTLV
QNSKPWERELDQQDNIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSKEKRTINYARL
GSDKTYGKQSNKKGREVPLKKIPFRLQEEQTNMRS |
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References |
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External Links | |
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General Reference | - Tzagoloff, A., Vambutas, A., Akai, A. (1989). "Characterization of MSM1, the structural gene for yeast mitochondrial methionyl-tRNA synthetase." Eur J Biochem 179:365-371.2645139
- Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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