Serine/threonine-protein kinase VPS15 (P22219)
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| Name | Serine/threonine-protein kinase VPS15 | |||||||||||||||||||
| Synonyms |
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| Gene Name | VPS15 | |||||||||||||||||||
| Enzyme Class | Not Available | |||||||||||||||||||
| Biological Properties | ||||||||||||||||||||
| General Function | vacuole inheritance | |||||||||||||||||||
| Specific Function | Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole. | |||||||||||||||||||
| Cellular Location | Not Available | |||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | |||||||||||||||||||
| SMPDB Reactions |
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| KEGG Reactions | Not Available | |||||||||||||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | ||||||||||||||||||||
| Chromosome Location | Not Available | |||||||||||||||||||
| Locus | ||||||||||||||||||||
| Gene Sequence | >4365 bp ATGGGGGCACAATTATCACTAGTGGTCCAAGCATCACCTTCCATAGCCATTTTTTCATAT ATCGATGTCTTAGAGGAAGTACACTACGTTTCACAGTTAAACTCATCAAGATTCTTAAAA ACATGCAAGGCACTGGACCCTAACGGCGAAATTGTTATCAAAGTGTTTATTAAACCAAAA GACCAATATAGCTTACGACCTTTTCTCCAACGTATAAGGGCTCAATCGTTTAAGTTGGGA CAACTACCGCACGTTTTAAACTACAGTAAATTGATCGAGACAAATAGAGCCGGCTACATG ATACGGCAGCACTTAAAAAATAATTTATATGACAGATTGAGTTTGAGACCTTACTTACAA GACATTGAACTGAAATTCATTGCTTTCCAGTTGTTAAATGCATTAAAGGACATTCATAAT CTGAATATTGTCCATGGTGATATAAAGACAGAAAATATCCTAGTAACAAGTTGGAATTGG TGTATATTGACAGATTTTGCTGCATTTATCAAACCCGTATATTTGCCTGAAGATAATCCA GGTGAATTTTTATTCTACTTCGACACCTCGAAGAGAAGAACCTGTTATCTAGCCCCGGAG AGGTTTAACTCTAAACTTTACCAAGATGGAAAATCTAACAATGGTAGGCTAACTAAAGAA ATGGACATATTTAGTCTTGGATGTGTTATTGCAGAAATATTTGCTGAAGGAAGACCCATC TTCAACTTATCACAGCTATTCAAATATAAAAGTAATTCATATGACGTAAACAGGGAATTT CTCATGGAGGAAATGAATTCTACCGATTTAAGGAACTTGGTTCTAGACATGATTCAACTA GATCCATCCAAAAGACTTTCATGTGATGAACTACTGAATAAATATCGTGGCATTTTCTTC CCCGATTATTTCTACACTTTCATTTATGATTATTTCAGAAATTTGGTTACTATGACAACA AGCACACCGATATCAGATAACACTTGCACCAATAGTACCTTGGAAGACAATGTAAAACTT TTAGATGAAACTACGGAAAAAATATACAGAGATTTTTCCCAAATATGTCATTGTTTGGAC TTTCCTTTAATAAAAGACGGGGGTGAGATTGGTTCAGACCCCCCAATTTTGGAATCTTAC AAAATAGAGATAGAAATTAGTCGGTTTTTAAACACAAACTTATATTTCCCCCAAAATTAC CATTTAGTCTTACAGCAGTTTACCAAAGTATCCGAAAAGATAAAATCAGTTAAAGAGGAA TGTGCCTTACTCTTTATCTCTTATTTGTCTCATAGTATAAGAAGTATTGTTTCGACTGCT ACGAAACTTAAAAATTTAGAACTATTAGCAGTATTTGCACAATTCGTTTCTGATGAAAAT AAAATTGATCGAGTCGTACCTTATTTCGTATGTTGTTTTGAAGATAGTGACCAGGACGTC CAGGCCCTATCTTTGTTAACATTAATCCAGGTACTCACCTCTGTAAGAAAATTGAATCAA TTGAACGAGAATATATTTGTGGACTACTTACTTCCGAGACTGAAAAGATTACTTATTTCC AATAGGCAGAATACCAATTATTTAAGGATTGTGTTTGCTAATTGTTTGAGCGACTTGGCC ATTATCATTAATAGATTTCAAGAATTTACATTTGCTCAGCACTGCAATGATAACTCAATG GATAACAACACGGAAATCATGGAAAGCAGTACCAAGTATTCAGCAAAATTGATCCAAAGT GTCGAAGATTTAACTGTCTCTTTTTTAACAGATAATGATACTTATGTAAAGATGGCACTT TTGCAAAACATTCTTCCACTTTGTAAATTTTTTGGTAGGGAAAGAACAAACGATATTATA CTGAGTCATTTAATAACCTACCTTAATGATAAGGACCCAGCATTGCGAGTTTCCTTAATT CAAACAATATCCGGAATATCAATTCTTTTGGGTACCGTTACATTAGAACAGTATATTTTA CCATTGTTAATCCAGACCATCACTGATTCGGAAGAATTAGTAGTGATCAGTGTTTTACAA AGCTTAAAATCTTTGTTCAAGACTGGGTTGATTAGGAAAAAATATTATATTGATATATCA AAAACAACATCTCCCTTGTTGTTGCATCCTAATAATTGGATAAGACAGTTTACTTTGATG ATAATTATAGAAATTATTAATAAGTTATCAAAAGCCGAAGTGTACTGCATTCTCTATCCA ATAATAAGGCCTTTCTTCGAATTTGACGTTGAGTTCAACTTCAAATCAATGATAAGCTGT TGCAAGCAACCAGTGTCAAGATCGGTTTACAATCTATTGTGTAGTTGGTCTGTTAGAGCG TCAAAATCTTTATTTTGGAAAAAAATCATCACAAATCATGTAGATTCATTCGGAAATAAT AGAATCGAATTTATAACAAAAAATTACTCAAGTAAAAATTATGGATTTAATAAAAGAGAT ACGAAATCAAGTTCCTCGCTGAAGGGTATTAAAACATCATCCACCGTCTATTCACATGAC AACAAGGAAATTCCCTTAACTGCTGAAGACAGAAATTGGATTGATAAGTTCCACATTATT GGGCTAACAGAAAAAGATATTTGGAAAATTGTGGCTTTGAGGGGTTATGTAATAAGGACA GCGAGAGTTATGGCAGCGAACCCTGATTTTCCATATAATAATAGTAATTACCGTCCATTA GTACAGAACTCACCACCTAACCTAAACCTTACGAATATTATGCCAAGAAACATTTTCTTT GATGTAGAGTTTGCTGAAGAGTCGACAAGTGAGGGACAAGATTCTAACTTAGAGAACCAA CAGATATATAAATATGATGAAAGTGAGAAAGATAGCAATAAGCTAAATATTAACGGTAGC AAACAGCTATCTACCGTCATGGACATAAATGGATCACTAATATTCAAAAATAAGTCCATT GCCACTACTACTTCTAATTTGAAGAACGTTTTTGTTCAGTTAGAACCAACGTCCTATCAC ATGCATTCTCCAAATCATGGCTTGAAAGATAATGCAAATGTTAAACCAGAAAGGAAGGTA GTCGTCAGCAACAGCTATGAAGGCGACGTTGAAAGCATAGAAAAATTCCTATCGACTTTC AAAATTTTACCTCCTCTGAGAGATTATAAGGAGTTTGGGCCTATTCAAGAGATTGTACGG AGTCCAAACATGGGTAATTTGAGGGGCAAGTTGATAGCTACTTTGATGGAAAACGAACCC AATTCTATTACGTCTTCTGCTGTTTCTCCAGGAGAAACACCCTATTTAATAACAGGTTCA GATCAAGGTGTAATCAAGATTTGGAACCTGAAAGAGATTATCGTGGGCGAGGTTTACTCT TCTTCTTTAACTTATGACTGCTCCTCTACCGTAACTCAGATAACCATGATTCCTAACTTT GACGCGTTTGCCGTTTCCAGTAAAGATGGACAAATAATTGTATTAAAGGTTAATCATTAC CAACAAGAAAGTGAAGTCAAATTTTTGAATTGCGAATGCATCAGGAAAATTAACTTGAAG AATTTTGGTAAAAATGAATACGCAGTGAGAATGAGAGCATTTGTGAATGAGGAAAAATCT CTACTAGTAGCATTGACGAATTTGTCAAGGGTTATTATATTTGATATTAGAACCCTGGAG AGGTTACAAATTATAGAGAATTCTCCAAGGCATGGTGCCGTTTCAAGCATCTGTATCGAT GAAGAGTGTTGTGTCCTAATTTTGGGGACGACTAGAGGTATTATTGATATATGGGATATC CGTTTCAACGTGCTGATAAGGAGTTGGTCCTTTGGGGACCACGCACCAATCACGCATGTG GAGGTTTGTCAGTTTTATGGAAAGAATTCTGTAATTGTTGTAGGAGGTAGTTCAAAAACA TTTCTAACAATATGGAATTTTGTTAAGGGGCATTGTCAGTATGCTTTCATAAATTCTGAT GAACAGCCATCTATGGAGCACTTTTTACCAATTGAGAAAGGCTTAGAAGAATTAAATTTT TGTGGAATCAGGTCTTTAAACGCACTAAGCACTATCTCAGTATCTAATGATAAAATTCTT CTTACCGATGAAGCAACAAGTTCCATTGTTATGTTTAGCCTAAATGAGCTTTCTTCTTCT AAAGCAGTAATAAGTCCTTCAAGATTCAGTGACGTTTTTATTCCTACACAAGTTACGGCA AATCTCACAATGTTATTGAGAAAAATGAAACGTACTAGCACTCATTCAGTAGATGATTCT CTATATCATCATGATATTATAAATTCTATATCTACATGTGAAGTTGATGAGACACCTTTG CTGGTTGCTTGTGATAACTCAGGGCTTATTGGAATCTTCCAATAA | |||||||||||||||||||
| Protein Properties | ||||||||||||||||||||
| Pfam Domain Function | Not Available | |||||||||||||||||||
| Protein Residues | 1454 | |||||||||||||||||||
| Protein Molecular Weight | 166370.295 | |||||||||||||||||||
| Protein Theoretical pI | Not Available | |||||||||||||||||||
| PDB File | show | |||||||||||||||||||
| Signalling Regions | Not Available | |||||||||||||||||||
| Transmembrane Regions | Not Available | |||||||||||||||||||
| Protein Sequence | >Serine/threonine-protein kinase VPS15 MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPK DQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQ DIELKFIAFQLLNALKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNP GEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPI FNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFF PDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLD FPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEE CALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDV QALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLA IIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMAL LQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYIL PLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLM IIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRA SKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHD NKEIPLTAEDRNWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPL VQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGS KQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKV VVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEP NSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNF DAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNFGKNEYAVRMRAFVNEEKS LLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRGIIDIWDI RFNVLIRSWSFGDHAPITHVEVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSD EQPSMEHFLPIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSSIVMFSLNELSSS KAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDDSLYHHDIINSISTCEVDETPL LVACDNSGLIGIFQ | |||||||||||||||||||
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| General Reference | Not Available | |||||||||||||||||||