Cyclin-dependent kinase inhibitor FAR1 (P21268)

Identification
NameCyclin-dependent kinase inhibitor FAR1
Synonyms
  • CKI FAR1
  • Factor arrest protein
Gene NameFAR1
Enzyme ClassNot Available
Biological Properties
General Functionpheromone-dependent signal transduction involved in conjugation with cellular fusion
Specific FunctionInhibitor of the cyclin-dependent kinase CDC28. Necessary for cell cycle arrest. Involved in pheromone response. Contributes to mating efficiency. Required for oriented polarization of yeast cells in response to mating pheromones.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: pheromone stress test 1PW012843 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
nucleus
cytoplasm
cell division
mating projection tip
membrane
cyclin-dependent protein serine/threonine kinase inhibitor activity
maintenance of protein location in nucleus
mitotic cell cycle arrest in response to pheromone
zinc ion binding
pheromone-dependent signal transduction involved in conjugation with cellular fusion
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2493 bp ATGAAGACACCAACAAGAGTTTCGTTTGAAAAAAAAATACACACTCCACCAAGTGGAGAT CGTGACGCTGAAAGATCACCACCGAAGAAATTTCTAAGAGGTTTATCGGGTAAAGTTTTT AGAAAGACACCAGAATTTAAGAAGCAACAGATGCCCACATTTGGGTATATTGAAGAGAGT CAATTTACTCCAAATCTTGGCCTAATGATGTCCAAAAGAGGCAATATTCCTAAACCACTG AATCTTTCCAAGCCTATATCTCCCCCACCAAGTTTGAAGAAAACAGCGGGATCAGTAGCA TCTGGTTTTTCGAAAACAGGACAACTTAGCGCTTTACAATCGCCAGTAAATATCACAAGT AGCAACAAATACAACATCAAAGCTACAAATTTAACTACTAGTTTACTCCGAGAGTCGATT TCTGATTCTACAACTATGTGTGATACTTTGTCAGACATCAATTTAACGGTTATGGATGAA GATTATCGCATTGACGGCGATTCATATTACGAAGAAGATTCACCAACTTTCATGATCAGC CTGGAAAGAAACATAAAAAAATGCAATTCACAATTCAGTCCAAAAAGGTACATAGGTGAG AAATGTTTAATCTGTGAGGAAAGTATTAGTTCCACATTTACCGGTGAAAAGGTTGTGGAG TCTACGTGTTCACACACTAGCCACTATAACTGTTATTTGATGCTATTTGAAACTCTTTAT TTCCAAGGCAAGTTTCCTGAGTGTAAGATATGTGGCGAAGTGAGCAAGCCAAAGGATAAA GACATTGTTCCTGAAATGGTATCCAAACTTCTAACGGGCGCAGGCGCTCATGATGATGGT CCGTCATCCAATATGCAACAGCAATGGATTGATTTGAAAACGGCGAGAAGCTTCACAGGT GAATTTCCTCAGTTTACACCACAGGAGCAGCTCATTCGTACTGCTGATATTTCATGTGAT GGGTTCAGGACACCACGCTTATCGAATAGCAATCAATTTGAGGCCGTTAGCTATCTTGAT AGCCCATTTTTAAATTCACCATTCGTTAATAAAATGGCAACTACAGACCCTTTTGATTTA AGTGATGATGAAAAACTGGACTGTGATGATGAAATAGACGAAAGTGCTGCTGAAGTGTGG TTTAGTAAAACGGGTGGTGAACATGTTATGGTCAGTGTGAAGTTTCAAGAAATGCGGACC AGTGATGATTTAGGGGTCTTGCAAGATGTGAATCATGTGGACCACGAAGAACTAGAGGAA AGGGAAAAGGAATGGAAAAAGAAAATTGATCAATATATCGAAACAAATGTGGATAAGGAT AGCGAATTTGGCAGTTTGATCTTGTTTGACAAACTAATGTATTCTGATGATGGCGAACAA TGGGTAGACAATAACCTTGTAATATTATTCTCCAAATTTCTAGTTTTGTTTGATTTTGAA GAAATGAAGATCCTGGGTAAGATTCCTAGAGACCAGTTTTACCAGGTAATCAAGTTCAAT GAGGACGTACTACTTTGTAGTTTGAAGAGCACTAATATACCTGAAATATACTTGAGGTTC AACGAAAACTGCGAAAAGTGGTTGCTTCCCAAATGGAAGTATTGTCTAGAAAATTCTTCA CTGGAGACACTACCATTAAGTGAGATTGTTTCTACAGTGAAGGAACTCTCTCATGTGAAT ATAATAGGCGCTTTAGGAGCGCCGCCTGATGTTATATCAGCACAATCCCATGATTCTCGT CTACCGTGGAAAAGATTGCACAGTGATACGCCGCTAAAACTTATTGTATGTTTGAATTTG TCGCATGCTGATGGGGAACTGTATCGCAAGAGAGTTCTAAAGAGTGTTCATCAAATATTG GATGGATTAAACACAGACGATTTACTGGGAATAGTTGTTGTTGGAAGAGATGGATCCGGT GTAGTAGGCCCATTTGGCACCTTCATCGGAATGATAAATAAAAATTGGGACGGATGGACA ACTTTCTTGGATAATTTAGAAGTGGTTAATCCAAACGTCTTCCGCGATGAAAAGCAACAG TATAAGGTAACATTACAAACTTGTGAAAGATTAGCGTCAACAAGTGCATACGTGGATACA GATGACCATATTGCAACTGGATACGCCAAGCAAATCTTGGTCCTCAACGGGAGTGACGTT GTTGACATTGAGCATGATCAGAAATTAAAAAAGGCCTTTGACCAGTTATCTTACCATTGG AGATACGAAATTTCGCAACGCCGCATGACTCCATTGAACGCTAGCATTAAGCAGTTTTTA GAGGAGCTGCACACTAAGCGTTATCTAGATGTAACTCTTCGTCTACCACAAGCTACATTC GAGCAAGTATATTTGGGGGATATGGCTGCGGGTGAACAAAAAACGCGTCTAATTATGGAT GAACACCCGCATTCTAGTTTGATAGAAATAGAATATTTTGACCTGGTAAAGCAGCAAAGA ATTCATCAGACCCTGGAAGTTCCCAACCTCTAG
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues830
Protein Molecular Weight94571.415
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Cyclin-dependent kinase inhibitor FAR1 MKTPTRVSFEKKIHTPPSGDRDAERSPPKKFLRGLSGKVFRKTPEFKKQQMPTFGYIEES QFTPNLGLMMSKRGNIPKPLNLSKPISPPPSLKKTAGSVASGFSKTGQLSALQSPVNITS SNKYNIKATNLTTSLLRESISDSTTMCDTLSDINLTVMDEDYRIDGDSYYEEDSPTFMIS LERNIKKCNSQFSPKRYIGEKCLICEESISSTFTGEKVVESTCSHTSHYNCYLMLFETLY FQGKFPECKICGEVSKPKDKDIVPEMVSKLLTGAGAHDDGPSSNMQQQWIDLKTARSFTG EFPQFTPQEQLIRTADISCDGFRTPRLSNSNQFEAVSYLDSPFLNSPFVNKMATTDPFDL SDDEKLDCDDEIDESAAEVWFSKTGGEHVMVSVKFQEMRTSDDLGVLQDVNHVDHEELEE REKEWKKKIDQYIETNVDKDSEFGSLILFDKLMYSDDGEQWVDNNLVILFSKFLVLFDFE EMKILGKIPRDQFYQVIKFNEDVLLCSLKSTNIPEIYLRFNENCEKWLLPKWKYCLENSS LETLPLSEIVSTVKELSHVNIIGALGAPPDVISAQSHDSRLPWKRLHSDTPLKLIVCLNL SHADGELYRKRVLKSVHQILDGLNTDDLLGIVVVGRDGSGVVGPFGTFIGMINKNWDGWT TFLDNLEVVNPNVFRDEKQQYKVTLQTCERLASTSAYVDTDDHIATGYAKQILVLNGSDV VDIEHDQKLKKAFDQLSYHWRYEISQRRMTPLNASIKQFLEELHTKRYLDVTLRLPQATF EQVYLGDMAAGEQKTRLIMDEHPHSSLIEIEYFDLVKQQRIHQTLEVPNL
References
External Links
ResourceLink
Saccharomyces Genome Database FAR1
Uniprot IDP21268
Uniprot NameFAR1
General ReferenceNot Available