| Identification |
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| Name | Serine/threonine-protein phosphatase PP1-1 |
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| Synonyms | Not Available |
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| Gene Name | SIT4 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | tRNA wobble uridine modification |
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| Specific Function | Involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1. Associates with the SAP proteins in a cell cycle-dependent manner. |
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| Cellular Location | Not Available |
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| SMPDB Pathways | | TOR signalling pathway: Rapamycin based repression | PW002514 |    |
|
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | | URE2–GLN3
→
Nitrogen regulatory protein GLN3
+
Transcriptional regulator URE2
+
phosphate
| | Phosphorylated TIP41
→
Type 2A phosphatase activator TIP41
+
phosphate
|
|
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
|---|
| YMDB00907 | phosphate | Show |
|
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| GO Classification | | Function |
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| G1/S transition of mitotic cell cycle | | replicative cell aging | | TOR signaling | | tRNA wobble uridine modification | | metal ion binding | | cytoplasm | | cell division | | actin cytoskeleton organization | | intracellular signal transduction | | mitotic nuclear division | | protein serine/threonine phosphatase activity | | cellular response to oxidative stress | | dephosphorylation | | DNA repair | | fungal-type cell wall organization |
|
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >936 bp
ATGGTATCTAGAGGCCCCGACGAATGGCTTGAAACAATAAAGAAATGCCAGGCGCTAACT
GAAAACGAGATGAAACAACTGTGTGAAATGGTGAAAGAACTTTTGATGGAGGAAAGTAAC
ATCCAGCCGGTACAGACCCCCGTTACTGTATGTGGAGACATACACGGCCAATTTCATGAC
TTGTTAGAGCTATTCCGTACGGCGGGTGGCTTTCCTGACGATATAAACTACATTTTTCTC
GGTGATTACGTGGATCGTGGCTACTATAGTCTGGAAACTTTTACGCTTTTAATGTGTCTG
AAAGTCAAGTACCCGGCAAAGATAACTTTGGTCAGAGGAAACCATGAGTCCAGACAAATT
ACTCAAGTTTACGGGTTCTACGAGGAATGCCTGAATAAGTACGGATCTACCACCGTATGG
AAGTATTGCTGTCAAGTTTTTGATTTCCTGACGCTGGCCGCTATAATTGACGGTAAGATC
TTATGTGTCCATGGAGGGTTATCTCCCGAGATTAGAATGCTCGATCAAATCAGAGTCTTG
TCAAGAGCTCAAGAAGTGCCACACGAGGGTGGGTTCTCGGACCTGCTTTGGTCAGACCCT
GACAATGTAGAGGCTTGGCAAGTTTCCCCTCGTGGTGCAGGATGGCTCTTTGGCAGTAAA
GTTGCTAGAGAGTTTAACCACGTTAATGGACTGAACCTTATTGCCCGGGCTCACCAACTG
GTTATGGAGGGGTTCAAGTACCATTTTCCTGAAAAGGACGTTGTAACCGTGTGGTCCGCG
CCAAATTACTGTTATAGATGTGGTAATGTCGCGAGTGTAATGAAGGTCGATGAGGATCTG
GAACCTACTTTCAAAATTTTCTCGGCTGTTCCCGATGACTACATAAGAGAATCCACGGCA
AACCATAATAATCAAAGAGCCGGCTATTTCTTATAA |
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| Protein Properties |
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| Pfam Domain Function | Not Available |
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| Protein Residues | 311 |
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| Protein Molecular Weight | 35537.32 |
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| Protein Theoretical pI | Not Available |
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| Signalling Regions | Not Available |
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| Transmembrane Regions | Not Available |
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| Protein Sequence | >Serine/threonine-protein phosphatase PP1-1
MVSRGPDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHD
LLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQI
TQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVL
SRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQL
VMEGFKYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDYIRESTA
NHNNQRAGYFL |
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| References |
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| External Links | | Resource | Link |
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| Saccharomyces Genome Database | SIT4 | | Uniprot ID | P20604 | | Uniprot Name | SIT4 |
|
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| General Reference | Not Available |
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