Geranylgeranyl transferase type-2 subunit beta (P20133)

Identification
NameGeranylgeranyl transferase type-2 subunit beta
Synonyms
  • Geranylgeranyl transferase type II subunit beta
  • GGTase-II-beta
  • Type II protein geranyl-geranyltransferase subunit beta
  • PGGT
  • YPT1/SEC4 proteins geranylgeranyltransferase subunit beta
Gene NameBET2
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00219PyrophosphateShow
YMDB003592-trans,6-trans,10-trans-geranylgeranyl diphosphateShow
YMDB00631geranylgeranyl diphosphateShow
GO Classification
Component
Not Available
Function
catalytic activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 16
LocusYPR176C
Gene Sequence>978 bp ATGTCAGGATCTCTTACGCTACTTAAGGAAAAGCATATACGTTATATTGAATCATTGGAT ACAAAGAAGCATAATTTTGAATACTGGCTTACCGAGCATCTTCGTTTGAATGGGATATAT TGGGGACTTACTGCCTTGTGTGTGCTTGATTCTCCAGAGACATTTGTGAAAGAAGAGGTT ATATCATTTGTTCTGAGCTGTTGGGACGACAAATACGGCGCTTTCGCACCATTTCCAAGA CATGATGCACATTTATTAACTACATTGTCCGCCGTACAGATCTTGGCCACTTATGATGCT TTGGATGTTCTTGGAAAAGATCGTAAGGTTCGCTTGATTTCCTTCATCCGTGGGAATCAA TTGGAAGATGGTTCGTTCCAGGGTGACAGGTTTGGGGAGGTAGATACAAGGTTTGTTTAT ACAGCCTTGAGTGCACTATCAATTTTGGGTGAATTAACGTCTGAAGTTGTTGACCCTGCT GTAGACTTTGTACTCAAGTGTTATAATTTTGATGGTGGCTTTGGATTATGTCCTAATGCT GAATCCCATGCAGCTCAAGCTTTTACCTGTCTTGGCGCTTTGGCAATTGCTAACAAATTG GATATGCTTAGTGACGACCAACTAGAAGAAATTGGGTGGTGGCTTTGCGAACGACAATTA CCAGAAGGTGGACTAAACGGTAGGCCAAGTAAACTGCCCGATGTTTGCTATAGTTGGTGG GTTTTATCTTCATTAGCTATTATTGGTAGACTAGATTGGATAAATTATGAGAAGCTAACT GAGTTTATACTCAAATGTCAAGATGAGAAGAAGGGTGGAATAAGCGACAGGCCTGAAAAT GAAGTGGATGTCTTCCATACAGTTTTTGGTGTTGCTGGTTTAAGTTTAATGGGATACGAC AATTTAGTCCCCATAGATCCCATATATTGTATGCCGAAATCCGTTACATCAAAATTCAAA AAGTATCCATACAAATAG
Protein Properties
Pfam Domain Function
Protein Residues325
Protein Molecular Weight36665.60156
Protein Theoretical pI4.81
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Geranylgeranyl transferase type-2 subunit beta MSGSLTLLKEKHIRYIESLDTKKHNFEYWLTEHLRLNGIYWGLTALCVLDSPETFVKEEV ISFVLSCWDDKYGAFAPFPRHDAHLLTTLSAVQILATYDALDVLGKDRKVRLISFIRGNQ LEDGSFQGDRFGEVDTRFVYTALSALSILGELTSEVVDPAVDFVLKCYNFDGGFGLCPNA ESHAAQAFTCLGALAIANKLDMLSDDQLEEIGWWLCERQLPEGGLNGRPSKLPDVCYSWW VLSSLAIIGRLDWINYEKLTEFILKCQDEKKGGISDRPENEVDVFHTVFGVAGLSLMGYD NLVPIDPIYCMPKSVTSKFKKYPYK
References
External Links
ResourceLink
Saccharomyces Genome Database BET2
Uniprot IDP20133
Uniprot NamePGTB2_YEAST
GenBank Gene IDAY558067
Genebank Protein ID45270024
General Reference
  • Petersen-Bjorn, S., Harrington, T. R., Friesen, J. D. (1990). "An essential gene in Saccharomyces cerevisiae shares an upstream regulatory element with PRP4." Yeast 6:345-352.2204247
  • Rossi, G., Yu, J. A., Newman, A. P., Ferro-Novick, S. (1991). "Dependence of Ypt1 and Sec4 membrane attachment on Bet2." Nature 351:158-161.1903184
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Bjorn, S. P., Soltyk, A., Beggs, J. D., Friesen, J. D. (1989). "PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle." Mol Cell Biol 9:3698-3709.2528686
  • Jiang, Y., Rossi, G., Ferro-Novick, S. (1993). "Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p." Nature 366:84-86.8232542
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106