Hexaprenyl pyrophosphate synthase, mitochondrial (P18900)

Identification
NameHexaprenyl pyrophosphate synthase, mitochondrial
Synonyms
  • HPS
Gene NameCOQ1
Enzyme Class
Biological Properties
General FunctionInvolved in isoprenoid biosynthetic process
Specific FunctionAssembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species
Cellular LocationMitochondrion inner membrane; Peripheral membrane protein; Matrix side
SMPDB Pathways
Terpenoid backbone biosynthesisPW002485 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Terpenoid backbone biosynthesisec00900 Map00900
SMPDB Reactions
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → hexaprenyl diphosphate + Pyrophosphate
KEGG Reactions
pentaprenyl diphosphate + Isopentenyl pyrophosphate → Pyrophosphate + hexaprenyl diphosphate
Metabolites
YMDB IDNameView
YMDB00200Isopentenyl pyrophosphateShow
YMDB00219PyrophosphateShow
YMDB00229Farnesyl pyrophosphateShow
YMDB00632pentaprenyl diphosphateShow
YMDB00633hexaprenyl diphosphateShow
GO Classification
Component
Not Available
Function
Not Available
Process
primary metabolic process
lipid metabolic process
cellular lipid metabolic process
isoprenoid metabolic process
isoprenoid biosynthetic process
metabolic process
Gene Properties
Chromosome Locationchromosome 2
LocusYBR003W
Gene Sequence>1422 bp ATGTTTCAAAGGTCTGGCGCTGCTCATCACATCAAATTGATTTCATCTCGAAGATGCCGC TTTAAATCCTCCTTTGCAGTTGCTTTAAACGCTGCCAGTAAGTTGGTAACTCCCAAGATT CTTTGGAATAATCCCATATCATTAGTCTCGAAGGAGATGAACACATTGGCCAAAAATATA GTTGCCCTCATCGGGTCTGGCCATCCGGTGCTAAACAAGGTTACTAGTTACTATTTTGAA ACAGAAGGCAAAAAAGTACGTCCCTTGTTAGTGTTGTTGTTGTCAAGAGCACTTTCTGAA ATTCCCATGACAGAAAGAAATCACTTGAAAATTGACAAGTCGGATGTTCCTGAGGACCCA ATTTACTCTAAACCTAGTCAAAATCAACTATTTCAACGTCCTGCAAGTAGCATATCCCCA CTACATATTCTTCACGGTATTAAACCACTAAATCCCTTGACAAAAGGTCCTGAGCCTTTG CCAGAAGAAACTTTTGACAAACAAAGAGGGATTTTACCCAAACAGAGAAGATTAGCAGAG ATTGTAGAGATGATACACACTGCGTCTTTACTTCATGATGACGTTATTGATCATTCTGAT ACAAGAAGAGGAAGGCCAAGCGGAAATGCTGCCTTTACCAACAAGATGGCCGTTTTGGCG GGTGATTTTCTCTTAGGGAGAGCAACAGTGTCAATTTCAAGATTACACAACCCCGAAGTC GTAGAACTAATGTCTAATAGTATTGCGAATCTTGTCGAAGGTGAGTTCATGCAACTGAAA AATACTTCCATTGACGCGGATATCGATACCATCGAAAATGGCCATAAGCTACTTCCGGTT CCTTCTAAAAAGCTTGAAGTTAAAGAGCACGACTTTCGTGTTCCAAGCCGCCAACAGGGG CTGCAATTATCTCATGATCAGATTATAGAAACTGCATTTGAATACTACATACACAAGACC TATCTGAAGACTGCTGCTTTGATATCAAAATCTTGCAGATGTGCTGCTATATTATCTGGG GCATCACCTGCCGTTATCGACGAATGCTATGATTTCGGTAGAAATCTAGGTATATGTTTC CAACTCGTAGATGATATGCTTGATTTTACTGTGTCTGGAAAAGATTTAGGGAAGCCATCC GGCGCGGATCTAAAATTAGGTATTGCTACTGCTCCAGTCTTGTTTGCATGGAAAGAAGAC CCATCTTTAGGTCCACTAATTTCACGCAATTTTTCAGAGAGGGGTGATGTTGAAAAAACT ATTGATTCTGTGAGACTCCATAATGGTATAGCGAAGACGAAAATACTAGCGGAGGAATAT AGGGACAAGGCATTACAAAATCTACGGGATTCTCTTCCTGAATCTGATGCTCGTTCTGCC CTAGAGTTTTTAACTAATAGTATACTAACAAGAAGAAAGTAA
Protein Properties
Pfam Domain Function
Protein Residues473
Protein Molecular Weight52558.89844
Protein Theoretical pI9.26
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Hexaprenyl pyrophosphate synthase, mitochondrial MFQRSGAAHHIKLISSRRCRFKSSFAVALNAASKLVTPKILWNNPISLVSKEMNTLAKNI VALIGSGHPVLNKVTSYYFETEGKKVRPLLVLLLSRALSEIPMTERNHLKIDKSDVPEDP IYSKPSQNQLFQRPASSISPLHILHGIKPLNPLTKGPEPLPEETFDKQRGILPKQRRLAE IVEMIHTASLLHDDVIDHSDTRRGRPSGNAAFTNKMAVLAGDFLLGRATVSISRLHNPEV VELMSNSIANLVEGEFMQLKNTSIDADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQG LQLSHDQIIETAFEYYIHKTYLKTAALISKSCRCAAILSGASPAVIDECYDFGRNLGICF QLVDDMLDFTVSGKDLGKPSGADLKLGIATAPVLFAWKEDPSLGPLISRNFSERGDVEKT IDSVRLHNGIAKTKILAEEYRDKALQNLRDSLPESDARSALEFLTNSILTRRK
References
External Links
ResourceLink
Saccharomyces Genome Database COQ1
Uniprot IDP18900
Uniprot NameCOQ1_YEAST
GenBank Gene IDAY558099
Genebank Protein ID45270088
General Reference
  • Ashby, M. N., Edwards, P. A. (1990). "Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase." J Biol Chem 265:13157-13164.2198286
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  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Wolfe, K. H., Lohan, A. J. (1994). "Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4." Yeast 10 Suppl A:S41-S46.8091860
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106