Geranylgeranyl transferase type-1 subunit beta (P18898)

Identification
NameGeranylgeranyl transferase type-1 subunit beta
Synonyms
  • Cell division cycle protein 43
  • Geranylgeranyl transferase type I subunit beta
  • GGTase-I-beta
  • RAS proteins geranylgeranyltransferase subunit beta
  • Type I protein geranyl-geranyltransferase subunit beta
  • PGGT
Gene NameCDC43
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00219PyrophosphateShow
YMDB00229Farnesyl pyrophosphateShow
YMDB003592-trans,6-trans,10-trans-geranylgeranyl diphosphateShow
YMDB00631geranylgeranyl diphosphateShow
GO Classification
Component
Not Available
Function
catalytic activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 7
LocusYGL155W
Gene Sequence>1131 bp ATGTGTCAAGCTACCAATGGCCCGAGTAGAGTTGTGACTAAAAAGCATAGGAAATTTTTC GAAAGACATCTACAGTTGCTTCCCTCTTCACATCAGGGACATGACGTGAACAGAATGGCG ATAATATTCTACTCAATCTCAGGACTCTCTATATTTGATGTTAACGTTTCTGCGAAGTAC GGCGATCATCTTGGCTGGATGCGCAAACATTATATCAAAACAGTGCTGGATGATACAGAA AATACTGTGATATCTGGATTTGTTGGAAGCTTAGTCATGAATATCCCTCACGCAACAACG ATTAATCTACCAAATACTCTCTTTGCATTGTTGTCCATGATTATGCTGAGAGATTACGAG TATTTTGAGACTATACTAGACAAAAGAAGCCTGGCGAGATTTGTTTCTAAGTGCCAACGA CCTGACCGTGGCTCGTTTGTATCTTGTTTAGACTATAAGACAAATTGTGGATCTTCGGTT GATTCAGACGATTTAAGGTTTTGCTACATCGCAGTTGCCATTCTGTACATATGCGGATGC CGATCCAAAGAAGACTTTGATGAATACATTGATACTGAGAAGTTGCTTGGCTATATAATG TCGCAACAATGCTACAACGGAGCTTTCGGTGCCCACAATGAACCACACTCAGGGTACACA TCTTGTGCGCTGTCTACCTTAGCTTTACTCTCTAGTTTGGAAAAGCTATCAGACAAGTTT AAAGAAGACACCATAACCTGGCTATTACATAGGCAAGTATCAAGCCATGGATGTATGAAA TTTGAAAGCGAATTGAATGCCAGCTATGATCAATCTGATGATGGCGGTTTCCAGGGAAGG GAGAACAAGTTCGCTGATACGTGTTACGCATTTTGGTGCTTAAATTCACTACACTTACTA ACAAAGGATTGGAAAATGCTATGCCAAACTGAACTAGTCACAAATTATTTGCTTGATCGA ACGCAAAAAACATTAACTGGAGGCTTTAGTAAAAATGACGAAGAAGATGCTGATTTATAT CACAGCTGTCTAGGGAGCGCTGCGTTAGCATTAATTGAGGGGAAATTTAATGGAGAATTA TGCATACCTCAAGAAATATTTAATGATTTTAGTAAAAGGTGCTGTTTTTGA
Protein Properties
Pfam Domain Function
Protein Residues376
Protein Molecular Weight42689.10156
Protein Theoretical pI6.31
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Geranylgeranyl transferase type-1 subunit beta MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKY GDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYE YFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGC RSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKF KEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLL TKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGEL CIPQEIFNDFSKRCCF
References
External Links
ResourceLink
Saccharomyces Genome Database CDC43
Uniprot IDP18898
Uniprot NamePGTB1_YEAST
GenBank Gene IDM74109
Genebank Protein ID171147
General Reference
  • Johnson, D. I., O'Brien, J. M., Jacobs, C. W. (1990). "Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae." Gene 90:93-98.2199333
  • Johnson, D. I., O'Brien, J. M., Jacobs, C. W. (1991). "Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae." Gene 98:149-150.2013407
  • Ohya, Y., Goebl, M., Goodman, L. E., Petersen-Bjorn, S., Friesen, J. D., Tamanoi, F., Anraku, Y. (1991). "Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM) gene involved in ras processing." J Biol Chem 266:12356-12360.2061313
  • James, C. M., Indge, K. J., Oliver, S. G. (1995). "DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43." Yeast 11:1413-1419.8585324
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Finegold, A. A., Johnson, D. I., Farnsworth, C. C., Gelb, M. H., Judd, S. R., Glomset, J. A., Tamanoi, F. (1991). "Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product." Proc Natl Acad Sci U S A 88:4448-4452.2034682
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106