Mitochondrial distribution and morphology protein 10 (P18409)

Identification
NameMitochondrial distribution and morphology protein 10
Synonyms
  • Mitochondrial inheritance component MDM10
Gene NameMDM10
Enzyme ClassNot Available
Biological Properties
General Functionprotein import into mitochondrial outer membrane
Specific FunctionComponent of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
Cellular LocationNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(15:1(11Z)/20:1(11Z)/15:1(11Z)/20:1(13Z))PW012095 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(15:1(11Z)/20:1(11Z)/15:1(9Z)/20:1(11Z))PW012096 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(15:1(11Z)/20:1(11Z)/15:1(9Z)/20:1(13Z))PW012097 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(15:1(11Z)/20:1(13Z)/15:1(11Z)/20:1(11Z))PW012098 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(15:1(11Z)/20:1(13Z)/15:1(11Z)/20:1(13Z))PW012099 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
ERMES complex
integral component of mitochondrial outer membrane
mitochondrial sorting and assembly machinery complex
establishment of mitochondrion localization
mitochondrial genome maintenance
mitochondrial outer membrane translocase complex assembly
mitochondrion-ER tethering
phospholipid transport
protein import into mitochondrial outer membrane
mitochondrion organization
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1482 bp ATGCTACCCTATATGGACCAAGTACTAAGGGCATTTTATCAGAGCACCCATTGGAGTACG CAAAATAGCTACGAGGATATAACGGCCACATCGAGAACATTATTAGATTTCCGAATTCCC TCAGCAATACACCTGCAAATTTCCAACAAATCTACTCCCAATACATTCAATTCTTTAGAT TTTTCTACGAGGTCCAGGATAAATGGTTCTCTGAGTTATTTATACTCCGATGCACAGCAA TTGGAGAAATTCATGCGCAACTCTACTGATATCCCATTACAAGATGCCACCGAAACATAC AGACAATTGCAACCAAACCTCAATTTCAGTGTTAGTAGTGCGAATACGTTGAGTAGTGAC AACACCACAGTCGACAATGACAAGAAATTACTACATGACTCGAAATTTGTTAAAAAATCC CTTTATTATGGTAGAATGTACTACCCCAGCTCTGATTTAGAAGCAATGATAATAAAACGA CTAAGTCCACAAACCCAATTTATGCTTAAGGGTGTCAGTAGTTTCAAAGAAAGCTTAAAC GTTTTAACGTGCTATTTTCAAAGAGATTCTCACCGCAATTTACAGGAGTGGATATTTTCC ACCAGTGATCTATTATGTGGTTATAGAGTATTACACAATTTCCTTACCACGCCTTCCAAG TTTAACACCTCACTGTACAATAATTCTTCGTTGTCGCTTGGTGCTGAATTTTGGTTAGGG TTAGTAAGTTTAAGCCCCGGTTGTTCGACAACTTTAAGATATTACACACATTCTACAAAC ACAGGACGACCACTAACTTTGACATTATCTTGGAATCCATTATTCGGCCATATATCCTCC ACATATTCGGCCAAGACAGGGACAAATTCTACTTTTTGCGCGAAGTATGATTTTAATCTT TATTCGATTGAATCAAATCTTTCATTTGGGTGCGAATTTTGGCAAAAAAAGCATCATTTG CTTGAAACCAATAAAAACAATAATGATAAATTAGAACCAATCTCCGACGAATTGGTTGAT ATAAATCCAAACAGCAGAGCGACTAAACTACTGCACGAAAATGTACCGGATCTGAATTCA GCTGTTAACGATATTCCTTCTACACTAGATATACCTGTTCACAAACAAAAGCTATTAAAT GATTTAACTTATGCATTCTCGTCGTCATTAAGAAAAATCGATGAAGAAAGATCTACCATC GAAAAATTTGATAACAAAATAAATAGTTCCATTTTTACCAGTGTTTGGAAATTAAGCACG TCATTACGTGACAAGACTTTAAAACTATTATGGGAAGGCAAATGGAGGGGATTTTTAATA TCTGCCGGGACAGAGCTGGTATTCACTAGAGGCTTTCAAGAAAGTTTATCCGATGATGAA AAGAATGATAATGCAATATCTATATCAGCAACTGATACAGAAAACGGCAATATACCAGTT TTCCCGGCAAAGTTTGGCATACAATTCCAGTACTCCACATGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues493
Protein Molecular Weight56236.39
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Mitochondrial distribution and morphology protein 10 MLPYMDQVLRAFYQSTHWSTQNSYEDITATSRTLLDFRIPSAIHLQISNKSTPNTFNSLD FSTRSRINGSLSYLYSDAQQLEKFMRNSTDIPLQDATETYRQLQPNLNFSVSSANTLSSD NTTVDNDKKLLHDSKFVKKSLYYGRMYYPSSDLEAMIIKRLSPQTQFMLKGVSSFKESLN VLTCYFQRDSHRNLQEWIFSTSDLLCGYRVLHNFLTTPSKFNTSLYNNSSLSLGAEFWLG LVSLSPGCSTTLRYYTHSTNTGRPLTLTLSWNPLFGHISSTYSAKTGTNSTFCAKYDFNL YSIESNLSFGCEFWQKKHHLLETNKNNNDKLEPISDELVDINPNSRATKLLHENVPDLNS AVNDIPSTLDIPVHKQKLLNDLTYAFSSSLRKIDEERSTIEKFDNKINSSIFTSVWKLST SLRDKTLKLLWEGKWRGFLISAGTELVFTRGFQESLSDDEKNDNAISISATDTENGNIPV FPAKFGIQFQYST
References
External Links
ResourceLink
Saccharomyces Genome Database MDM10
Uniprot IDP18409
Uniprot NameMDM10
General ReferenceNot Available