Purine-cytosine permease FCY2 (P17064)

Identification
NamePurine-cytosine permease FCY2
Synonyms
  • PCP FCY2
  • Cytosine/purine transport protein FCY2
  • Fluorocytosine resistance protein 2
Gene NameFCY2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in nucleobase transmembrane transporter activity
Specific FunctionThis permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00651CytosineShow
YMDB00698GuanineShow
YMDB00862hydronShow
YMDB00887AdenineShow
GO Classification
Component
cell part
membrane
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
nucleobase transmembrane transporter activity
Process
transmembrane transport
establishment of localization
transport
nucleobase, nucleoside, nucleotide and nucleic acid transport
Gene Properties
Chromosome Locationchromosome 5
LocusYER056C
Gene Sequence>1602 bp ATGTTGGAAGAGGGAAATAATGTTTACGAAATCCAAGACTTGGAGAAGAGATCTCCTGTA ATAGGCTCAAGCTTGGAAAACGAAAAGAAGGTAGCCGCTTCTGAAACTTTCACAGCAACT TCCGAAGATGACCAACAGTATATCGTTGAATCATCAGAGGCCACAAAATTATCGTGGTTC CATAAGTTCTTTGCCAGTTTGAATGCAGAAACAAAGGGTGTTGAACCAGTTACAGAGGAT GAAAAAACGGACGATTCCATACTGAATGCTGCGTCCATGTGGTTTTCAGCTAATATGGTC ATTGCATCATATGCTTTGGGTGCCTTAGGACCCATGGTGTTCGGTCTAAATTTTGGTCAA AGTGTTTTAGTTATCATATTTTTCAATATAATGGGGTTGATATTTGTTGCGTTCTTTTCT GTCTTTGGTGCAGAACTGGGCTTAAGACAGATGATTTTATCAAGATATCTGGTTGGTAAT GTAACGGCAAGAATTTTCTCTCTTATTAACGTTATTGCTTGTGTCGGTTGGGGTATTGTG AATACCTCAGTATCCGCACAACTGCTGAATATGGTGAATGAAGGCTCCGGCCACGTCTGT CCTATTTGGGCCGGTTGTCTGATCATTATTGGTGGTACCGTGCTTGTGACTTTTTTTGGT TACAGTGTCATTCATGCATACGAGAAATGGTCATGGGTACCCAATTTTGCCGTCTTTTTG GTTATTATTGCCCAACTATCGAGATCAGGAAAGTTTAAAGGTGGTGAATGGGTAGGAGGT GCAACTACTGCAGGTAGTGTTCTTTCTTTTGGTTCATCTATTTTCGGTTTTGCCGCAGGA TGGACGACCTATGCAGCTGACTACACTGTTTATATGCCAAAGAGTACAAACAAGTACAAG ATTTTTTTCTCCCTAGTTGCTGGTCTAGCGTTCCCTCTATTTTTCACCATGATTCTTGGT GCTGCTTCTGCTATGGCTGCTCTTAATGACCCAACCTGGAAGGCATATTATGACAAAAAT GCTATGGGTGGTGTCATATATGCTATCCTGGTTCCTAACTCTCTGAACGGATTTGGTCAA TTCTGCTGCGTTTTGTTAGCTCTGTCCACTATTGCAAATAATATTCCAAATATGTATACT GTTGCTTTATCCGCTCAAGCTTTGTGGGCACCTTTGGCTAAAATACCAAGAGTAGTCTGG ACAATGGCAGGTAATGCTGCCACTTTAGGTATTTCCATCCCTGCTACCTATTACTTTGAT GGCTTTATGGAGAATTTCATGGATTCTATCGGTTACTACTTAGCTATTTACATTGCCATC TCATGTTCAGAACATTTCTTCTACAGACGTTCCTTCAGTGCTTACAATATTGATGATTGG GATAATTGGGAGCATCTACCTATCGGTATCGCAGGTACTGCTGCCTTAATTGTTGGTGCC TTCGGTGTTGCATTGGGTATGTGTCAAACCTATTGGGTTGGTGAAATTGGCCGCTTAATT GGTAAATATGGTGGTGACATTGGGTTCGAGTTGGGTGCAAGTTGGGCCTTCATCATCTAC AACATCTTAAGACCTTTAGAATTAAAATACTTCGGTCGTTAG
Protein Properties
Pfam Domain Function
Protein Residues533
Protein Molecular Weight58200.69922
Protein Theoretical pI4.86
Signalling Regions
  • None
Transmembrane Regions
  • 99-119
  • 122-141
  • 199-218
  • 257-276
  • 301-320
  • 348-367
  • 399-418
  • 466-485
Protein Sequence>Purine-cytosine permease FCY2 MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQQYIVESSEATKLSWF HKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASYALGALGPMVFGLNFGQ SVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTARIFSLINVIACVGWGIV NTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYSVIHAYEKWSWVPNFAVFL VIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGWTTYAADYTVYMPKSTNKYK IFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKNAMGGVIYAILVPNSLNGFGQ FCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFD GFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNIDDWDNWEHLPIGIAGTAALIVGA FGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAFIIYNILRPLELKYFGR
References
External Links
ResourceLink
Saccharomyces Genome Database FCY2
Uniprot IDP17064
Uniprot NameFCY2_YEAST
GenBank Gene IDU18813
Genebank Protein ID603292
General Reference
  • Weber, E., Rodriguez, C., Chevallier, M. R., Jund, R. (1990). "The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product." Mol Microbiol 4:585-596.2191181
  • Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
  • Hinnebusch, A. G., Fink, G. R. (1983). "Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae." J Biol Chem 258:5238-5247.6300123
  • Rodriguez, C., Bloch, J. C., Chevallier, M. R. (1995). "The immunodetected yeast purine-cytosine permease is not N-linked glycosylated, nor are glycosylation sequences required to have a functional permease." Yeast 11:15-23.7762297
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Mol Cell Proteomics 4:310-327.15665377
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258